公开(公告)号：US11215729B2

公开(公告)日：2022-01-04

申请号：US16922541

申请日：2020-07-07

申请人： Saudi Arabian Oil Company

发明人： Hassan W. Al Hashim ,  Jinxun Wang ,  Abdulkareem AlSofi ,  Amar Jaber M. Alshehri

IPC分类号： G01V3/32 ,  G01N15/08 ,  G01R33/50

摘要： Techniques for analyzing a sample include preparing a sample; circulating a gel solution through the sample to saturate the sample; scanning the saturated sample with a nuclear magnetic resonance (NMR) system to determine two or more NMR values of the saturated sample; determining a permeability of the saturated sample based, at least in part, on the two or more NMR values of the saturated sample; aging the saturated sample; scanning the aged sample with the NMR system to determine two or more NMR values of the aged sample; determining a permeability of the aged sample based, at least in part, on the two or more NMR values of the aged sample; comparing the determined permeability of the saturated sample against the determined permeability of the aged sample; and based on the compared permeabilities, determining a gel solution syneresis rate.

公开(公告)号：US11187768B2

公开(公告)日：2021-11-30

申请号：US16500515

申请日：2018-04-06

申请人： King's College London

发明人： Rui Pedro Azeredo Gomes Teixeira ,  Joseph Vilmos Hajnal ,  Shaihan Jalal Malik ,  Daniel John West

IPC分类号： G01V3/00 ,  G01R33/50 ,  G01R33/483 ,  G01R33/56 ,  G01R33/561

摘要： The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.

公开(公告)号：US20210361167A1

公开(公告)日：2021-11-25

申请号：US17277034

申请日：2019-09-17

申请人： Tatiana WOLFE ,  Caio C. QUINI ,  Philip J. HORNER ,  Matthew K. K. HOGAN ,  THE METHODIST HOSPITAL SYSTEM

发明人： Tatiana WOLFE ,  Caio C. QUINI ,  Philip J. HORNER ,  Matthew K. HOGAN

IPC分类号： A61B5/00 ,  A61B5/055 ,  G01R33/50 ,  G01R33/56 ,  G01R33/563 ,  G16H30/20 ,  G16H30/40

摘要： The exemplified system and method facilitate an objective, non-invasive measurement of myelin quality and integrity in living brains based on isolation of myelin-specific magnetic relaxation constants in k-space. The system uses magnetic resonance (MR) signals to select signatures specific to, or associated with, myelin and its structure and to then encode the selected signatures into an image or model to which the quantitative myelin health information can be co-registered with 2D, 3D visualization, and tractography of the myelin-signal isolated MR information. The system also sets a model for digital hierarchical learning of biomedical signals in MR, and beyond, based on experimental data in which it executes the herein described signal isolation operations.

公开(公告)号：US11179052B2

公开(公告)日：2021-11-23

申请号：US16159888

申请日：2018-10-15

申请人： Case Western Reserve University

发明人： Mark A. Griswold ,  Anagha Deshmane ,  Jeffrey Sunshine

IPC分类号： A61B5/026 ,  A61B5/055 ,  A61B5/00 ,  G01R33/563 ,  G01R33/44 ,  G01R33/48 ,  G01R33/565 ,  G01R33/56 ,  G01R33/561 ,  A61B1/00 ,  G01R1/00 ,  A61B17/00 ,  G06T1/00 ,  G01R33/50

摘要： Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing diseased tissue from healthy tissue based on tissue component fractions identified using the NMR fingerprinting.

公开(公告)号：US20210318403A1

公开(公告)日：2021-10-14

申请号：US17271726

申请日：2019-08-28

申请人： Erasmus University Medical Center Rotterdam

发明人： Gyula KOTEK ,  Juan Antonio HERNÁNDEZ TAMAMES

IPC分类号： G01R33/50 ,  A61B5/055 ,  G01R33/56 ,  G01R33/561

摘要： A method for magnetic resonance imaging (MRI) comprises applying a consecutive series of MRI sequences to a target volume (V) according to experimental settings (TR, α, β). A discrete sequence of transient response signals (Sn, Sn+1,Sn+2) is measured and fitted to a fit function (F) that is continuously dependent on a sequence number (n) of the respective MRI sequence (Pn) and corresponding response signal (Sn). A shape of the fit function is determined according to an analytically modelled evolution by the experimental parameters (TR, α, β) as well as variable intrinsic parameters (r,λ3, φ, δ) to be fitted. For example, the model is based on an equivalent harmonic oscillator. The intrinsic parameters of the fit function can be related to the intrinsic properties (PD,T1,T2) of the spin systems and used for imaging the target volume (V). Various optimizations of contrast can be achieved by tuning the experimental settings according to the model.

公开(公告)号：US20210308488A1

公开(公告)日：2021-10-07

申请号：US17346109

申请日：2021-06-11

申请人： ViewRay Technologies, Inc.

发明人： James F. Dempsey

IPC分类号： A61N5/10 ,  A61B5/055 ,  A61B5/00 ,  G01R33/50

摘要： Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.

公开(公告)号：US11119173B2

公开(公告)日：2021-09-14

申请号：US16575649

申请日：2019-09-19

申请人： Neusoft Medical Systems Co., Ltd.

发明人： Feng Huang

IPC分类号： G01R33/50 ,  G01R33/561 ,  G01R33/563

摘要： Methods, devices, systems and apparatus for dynamic imaging based on echo planar imaging (EPI) sequence are provided. In one aspect, a method includes: obtaining first pre-scanned k-space data by performing a pre-scan for a subject based on a first EPI sequence and pre-scanning parameters, obtaining a pre-scanned image and second pre-scanned k-space data according to the first pre-scanned k-space data, performing a dynamic scan for the subject based on a second EPI sequence and dynamic scanning parameters to generate dynamically-scanned k-space data associated with each of a plurality of dynamic periods in the dynamic scan, and for each of the dynamic periods, generating a residual image according to the dynamically-scanned k-space data of the dynamic period and the second pre-scanned k-space data, and adding the pre-scanned image and the residual image to obtain a dynamic image of the dynamic period.

公开(公告)号：US20210256691A1

公开(公告)日：2021-08-19

申请号：US17176725

申请日：2021-02-16

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Farshid Sepehrband ,  Jeiran Choupan

IPC分类号： G06T7/00 ,  G01R33/50 ,  G01R33/56 ,  G06T7/11 ,  G01R33/563

摘要： Systems and methods for mapping brain perivascular spaces. A system may include a memory to store one or more images of a brain of a patient. The system may further include a processor coupled to the memory. The processor may be configured to obtain a first and a second image of the brain. The processor may be further configured to combine the first image and the second image to preserve and magnify structures including the brain perivascular spaces within the image of the brain. The processor may be further configured to determine the brain perivascular spaces within the combined image of the brain of the patient. The processor may be further configured to generate a three-dimensional (3-D) map of the perivascular spaces. The system may further include a display configured to display the perivascular spaces to an operator.

公开(公告)号：US11085981B2

公开(公告)日：2021-08-10

申请号：US16419155

申请日：2019-05-22

申请人： Canon Medical Systems Corporation

发明人： Shuhei Bannae ,  Shigeharu Ohyu

IPC分类号： G01R33/50 ,  A61B5/055 ,  G01R33/54 ,  G01R33/56

摘要： According to one embodiment, an MRI apparatus includes sequence control circuitry and processing circuitry. The sequence control circuitry executes a pulse sequence for collecting MR signals in collection timings along a relaxation curve of longitudinal magnetization in synchronization with heartbeats or blood beats. The processing circuitry generate a T1 map representing a distribution of T1 values by using the collected MR signals. The pulse sequence is set so as not to collect any MR signal in at least one heartbeat or blood beat among heartbeats or blood beats included between first and second inversion pulses, and so as to collect an MR signal in a heartbeat or blood beat subsequent to the at least one heartbeat or blood beat in which no MR signal is collected.

公开(公告)号：US11085980B2

公开(公告)日：2021-08-10

申请号：US15593894

申请日：2017-05-12

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Samuel W. Fielden ,  John P. Mugler, III ,  G. Wilson Miller, IV ,  Kim Butts Pauly ,  Craig H. Meyer

IPC分类号： G01R33/50 ,  G01R33/48 ,  A61B5/055 ,  A61B5/01 ,  A61N7/00 ,  A61N7/02 ,  A61B90/00

摘要： In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.