公开(公告)号：US20250145548A1

公开(公告)日：2025-05-08

申请号：US18817775

申请日：2024-08-28

Applicant: University of Virginia Patent Foundation ,  Iowa State University Research Foundation, Inc.

Inventor： Sen Zhang ,  Zhouyang Yin ,  Long Qi ,  Wenyu Huang ,  Jiaqi Yu

IPC: C07C1/12 ,  B01J23/72 ,  B01J27/24 ,  B01J35/45 ,  B01J37/04

Abstract: The present disclosure provides for hybrid catalysts, methods of converting CO2 to C2 products (e.g., ethylene), systems for converting CO2 to C2 products (e.g., ethylene), and the like. The hybrid catalyst of the present disclosure effectively uses two steps of converting CO2 to ethylene in a single hybrid catalyst.

公开(公告)号：US20250123298A1

公开(公告)日：2025-04-17

申请号：US18684561

申请日：2022-08-17

Applicant: University of Virginia Patent Foundation ,  Inova Health Care Services

Inventor： Jason Aaron Papin ,  Sean Ryan Moore ,  Thomas James Moutinho, Jr. ,  Suchitra Kaveri Hourigan ,  Gabriel Hanson

IPC: G01N33/92

Abstract: Provided are biomarkers for parenteral nutrition associated cholestasis (PNAC) in subjects, especially infants receiving parenteral nutrition (PN). Using such biomarkers provide methods of diagnosing and/or assessing risk of PNAC in a subject, including screening a sample from a subject believed to be at risk for PNAC for one or more biomarkers of PNAC. The biomarkers can include one or more fecal metabolites. Such biomarkers and associated methods provide neonatal intensive care unit clinicians with an additional tool for early identification of PNAC risk. Early identification of high-risk infants would enable clinicians to confidently optimize caloric nutrition with PN for infants at low risk of developing PNAC and enable proactive mitigation with alterations to the administered PN.

公开(公告)号：US20250107783A1

公开(公告)日：2025-04-03

申请号：US18902235

申请日：2024-09-30

Applicant: University of Virginia Patent Foundation

Inventor： Mark D. Miller ,  Ian A. Backlund

IPC: A61B10/00

Abstract: Provided are embodiments of a device, having a device body suitable to hold a syringe. The device body can have an elongated member with a distal support and a proximal support. The device further includes a ratcheting rod configured to fit moveably within an open chamber in the elongated member, where the ratcheting rod has a proximal end configured to connect to a plunger of the syringe. The device can include a lever handle hingedly connected to a distal end of the device body, and a ratcheting lever hingedly connected to a distal end of the lever handle and positioned to interact with the ratcheting rod. Compression of the lever handle forces the ratcheting lever to extend the ratcheting rod in a proximal direction and to extract the plunger of the syringe.

公开(公告)号：US12262766B2

公开(公告)日：2025-04-01

申请号：US17607931

申请日：2020-05-01

Applicant: University of Virginia Patent Foundation

Inventor： Patricia A. Cady

IPC: A61F5/00 ,  A41B13/06 ,  A41D13/12 ,  A61F5/37 ,  A61J15/00

Abstract: A protective vest device that will adequately secure an infant from the ability to self-dislodge medical life-sustaining supply lines or equipment, while also supporting proper body alignment. The protective device mitigates self-dislodgement while allowing for free movement and proper alignment of infant's arms and hands and which are allowed to touch one another, thereby not inhibiting the ability to explore and expand brain development through tactile stimulation and therefore fostering healthy neuronal pathways of the infant. The fostering healthy neuronal pathways is provided by, for example, allowing the hands to touch one another as the infant develops a sense of where it is in space and time as it continues to grow outside of the womb. By maintaining proper body alignment of infant in the device and the configuration of the device, the device supports healthy musculoskeletal development with a stretchy womb like material to mimic the spring back effect of the uterine wall when a fetus pushes against a uterus.

公开(公告)号：US12226401B2

公开(公告)日：2025-02-18

申请号：US18164175

申请日：2023-02-03

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/68 ,  A61K31/4178 ,  A61K31/7048 ,  C12Q1/6883 ,  C12Q1/6888 ,  G16B20/00

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US20250054597A1

公开(公告)日：2025-02-13

申请号：US18931879

申请日：2024-10-30

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. KOVATCHEV ,  Stephen D. PATEK ,  Marc D. BRETON

IPC: G16H20/17 ,  A61B5/00 ,  A61B5/145 ,  G16H20/30 ,  G16H20/60 ,  G16H50/20 ,  G16H50/50

Abstract: A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.

公开(公告)号：US12221654B2

公开(公告)日：2025-02-11

申请号：US18394729

申请日：2023-12-22

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/6883 ,  A61K31/4178 ,  A61K45/06 ,  G01N33/68 ,  G01N33/94

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

公开(公告)号：US12209053B2

公开(公告)日：2025-01-28

申请号：US17294309

申请日：2019-11-15

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Andres F. Clarens ,  Dan A. Plattenberger

IPC: C04B28/18 ,  C04B22/06 ,  C04B40/02

Abstract: Disclosed are cementitious materials as well as methods of forming cured cementitious materials. In one aspect, provided are methods of forming a cured cementitious material that comprise (a) contacting a cementitious material comprising a calcium silicate precursor with water and carbon dioxide under conditions effective to form crystalline’calcium silicate hydrates within the cementitious material; and (b) allowing the cementitious material to harden to form the cured cementitious material.

公开(公告)号：US12178571B2

公开(公告)日：2024-12-31

申请号：US17333161

申请日：2021-05-28

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61B5/145 ,  A61B5/00 ,  A61M5/172 ,  G16H20/17 ,  G16H40/63 ,  G16H40/67 ,  G16H50/50

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US20240399336A1

公开(公告)日：2024-12-05

申请号：US18691134

申请日：2022-09-16

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Gaurav GIRI ,  Prince Kumar VERMA ,  Rachel A. LETTERI ,  Mara K. KUENEN ,  Mark S. BANNON

IPC: B01J20/22 ,  B01J20/28 ,  B01J20/32

Abstract: Embodiments disclosed herein provide methods of making polymer-metal organic framework-gels (polymer-MOF-gels), the method comprising forming a metal solution comprising a metal salt, an acid, and a first solvent, and forming a product mixture comprising the metal solution, a polymer, and a carboxylic acid linker to produce the polymer-MOF-gel. Embodiments disclosed herein provide polymer-MOF-gels comprising a polymer and a metal organic framework (MOF) having pores, wherein at least a portion of the polymer is entrapped in the pores of the MOF.