公开(公告)号：US20160264557A1

公开(公告)日：2016-09-15

申请号：US15068926

申请日：2016-03-14

Applicant: Almirall, S.A.

Inventor： Maria PRAT QUINONES ,  Silvia FONQUERNA POU ,  Carlos PUIG DURAN ,  Wenceslao LUMERAS AMADOR ,  Jose AIGUADE BOSCH ,  Juan Francisco CATURLA JAVALOYES

IPC: C07D409/14 ,  C07D409/12 ,  C07D215/26 ,  C07D413/14 ,  C07D405/12

CPC classification number: C07D409/14 ,  A61K31/4709 ,  C07D215/26 ,  C07D405/12 ,  C07D409/12 ,  C07D413/14

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Abstract translation: 本发明涉及具有β2肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。

公开(公告)号：US20160263091A1

公开(公告)日：2016-09-15

申请号：US15161531

申请日：2016-05-23

Applicant: Almirall, S.A.

Inventor： Maria Esther GARCIA GIL ,  Gonzalo DE MIQUEL SERRA ,  Maria Jose SALA PEINADO

IPC: A61K31/439 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/439 ,  A61K9/0073 ,  A61K9/0075 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the quality of sleep in respiratory patients.

Abstract translation: 本公开内容提供了吖啶鎓或其任何立体异构体或其立体异构体或其药学上可接受的盐或溶剂合物的混合物，用于改善呼吸患者的睡眠质量。

公开(公告)号：US09346759B2

公开(公告)日：2016-05-24

申请号：US14386424

申请日：2013-03-15

Applicant: ALMIRALL, S.A.

Inventor： Gemma Amat Mestres ,  Elvira Balaguer Ardanuy ,  Francesc Carrera Carrera ,  Iolanda Marchueta Hereu ,  Enrique Moyes Valls

IPC: C07D215/227 ,  C07D215/26 ,  A61K31/4704 ,  A61K45/06

CPC classification number: C07D215/227 ,  A61K31/4704 ,  A61K45/06 ,  C07B2200/13 ,  C07D215/26

Abstract: The present invention is directed to novel polymorphic crystal forms of a 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with β2 adrenergic receptor activity and a process for preparing such polymorphic crystal forms.

Abstract translation: 本发明涉及5-（2 - {[6-（2,2-二氟-2-苯基乙氧基）己基]氨基} -1-（R） - 羟基乙基）-8-羟基喹啉-3-酮的新型多晶型物， 2（1H） - 酮，半淀粉二酸酯。 本发明还涉及包含所述多晶型晶型的药物组合物，使用它们治疗与肾上腺素能受体活性相关的呼吸系统疾病的方法和制备这种多晶型晶形的方法。

公开(公告)号：US20150291595A1

公开(公告)日：2015-10-15

申请号：US14435851

申请日：2013-10-15

Applicant: ALMIRALL, S.A.

Inventor： Montserrat Erra Sola ,  Marta Carrascal Riera ,  Joan Taltavull Moll ,  Juan Francisco Caturla Javaloyes ,  Francisco Javier Bernal Anchuela ,  Lluis Miquel Pages Santacana ,  Marta Mir Cepeda ,  Gaspar Casals Coll ,  Maria Begoña Hernandez Olasagarre

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K45/06 ,  C07D519/00

Abstract: New pyrrolotriazinone derivatives having the chemical structure of Formula (I) are disclosed; as well as process for theft preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

Abstract translation: 公开了具有式（I）化学结构的新的吡咯并三嗪酮衍生物; 以及盗窃制备方法，包含它们的药物组合物及其在治疗中作为磷酸肌醇3-激酶（PI3Ks）抑制剂的用途。

公开(公告)号：US20140303127A1

公开(公告)日：2014-10-09

申请号：US14357400

申请日：2012-11-09

Applicant: ALMIRALL, S.A.

Inventor： Jose Aiguade Bosch ,  Silvia Gual Roig ,  Maria Prat Quinones ,  Carlos Puig Duran

IPC: C07D409/14 ,  A61K45/06 ,  C07D409/12 ,  A61K31/428 ,  C07D413/14 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/4709 ,  A61K31/4184

CPC classification number: A61K31/4184 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。

公开(公告)号：US08820321B2

公开(公告)日：2014-09-02

申请号：US13659174

申请日：2012-10-24

Applicant: Almirall, S.A.

Inventor： Joachim Goede ,  Karl-Heinz Lange

IPC: A61M15/00

CPC classification number: A61M15/0003 ,  A61M15/0066 ,  A61M2202/064

Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.

Abstract translation: 为了改进粉状药物的给药，本发明提出了一种用于粉末状药物的储存系统，特别是用于或整合在粉末吸入器中，用于接收多种剂量的至少一种医用活性物质，其中至少两个储存 空间（4）彼此分开并且各自用于容纳多种剂量的医疗活性物质，并且本发明还提出了一种用于粉末状药物的吸入器，该吸入器包括这样的药物粉末盒系统（1），如 组成部分或可交换部分。

公开(公告)号：US11602515B2

公开(公告)日：2023-03-14

申请号：US16625092

申请日：2018-06-25

Applicant: Almirall, S.A.

Inventor： Jorge Aubets Mir

IPC: A61K31/225 ,  A61P17/06 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28

Abstract: Pharmaceutical compositions are described comprising (a) dimethyl fumarate, (b) a diluent selected from monosaccharides, disaccharides, starch and starch derivatives, calcium and magnesium inorganic salts, sugar alcohols, and mixtures thereof, (c) microcrystalline cellulose and (d) croscarmellose sodium, wherein the dimethyl fumarate is not covered with a gastroresistant coating. These compositions are intended for the treatment of some inflammatory autoimmune diseases or disorders.

公开(公告)号：US20210220368A1

公开(公告)日：2021-07-22

申请号：US16309808

申请日：2017-06-15

Applicant: Almirall, S.A.

Inventor： Bernat Vidal Juan ,  Maria Victoria Revilla Sanchez ,  Gema Tarrason Encuentra

IPC: A61K31/5377 ,  A61P17/00 ,  A61K9/00 ,  A61K9/06

Abstract: The present invention relates to the use of timolol in treating rosacea, and to pharmaceutical compositions comprising timolol.

公开(公告)号：US10434268B2

公开(公告)日：2019-10-08

申请号：US14373563

申请日：2013-01-17

Applicant: Almirall, S.A.

Inventor： Martin Herder ,  Gerhard Ludanek ,  Ingo Mett ,  Joachim Schmidt

IPC: A61M15/00

Abstract: The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. Said dosage key (5) while being pressed is only temporarily engaged with said transportation mechanism such that a metering cycle while be completed and the transportation mechanism and/or the metering means will be reset even if said dosage key (5) will be held in depressed condition.

公开(公告)号：US10005771B2

公开(公告)日：2018-06-26

申请号：US15514294

申请日：2015-09-25

Applicant: Almirall, S.A.

Inventor： Carlos Puig Duran ,  Jose Aiguade Bosch ,  Silvia Gual Roig ,  Maria Prat Quiñones

IPC: C07D453/02 ,  A61K31/439

CPC classification number: C07D453/02 ,  C07D401/12

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.