公开(公告)号：US06455511B1

公开(公告)日：2002-09-24

申请号：US08899012

申请日：1997-07-23

Applicant: Jaap Kampinga ,  Camilo Colaco

Inventor： Jaap Kampinga ,  Camilo Colaco

IPC: A61K31715

CPC classification number: A23L2/60 ,  A23L2/395 ,  A23L33/16 ,  Y10S426/81

Abstract: The invention provides sports beverages which supply a readily metabolizable, natural carbohydrate, trehalose. The use of trehalose provides twice the concentration of glucose molecules for immediate energy compared to monosaccharide solutions of the same osmolarity.

公开(公告)号：US06313102B1

公开(公告)日：2001-11-06

申请号：US09389949

申请日：1999-09-03

Applicant: Camilo Colaco ,  Bruce J. Roser ,  Shevanti Sen

Inventor： Camilo Colaco ,  Bruce J. Roser ,  Shevanti Sen

IPC: A61K31715

CPC classification number: A61K31/00 ,  A61K9/19 ,  A61K31/155 ,  A61K31/70 ,  A61K38/00 ,  A61K47/22 ,  A61K47/26 ,  Y10T436/108331

Abstract: The present invention encompasses methods of increasing stability of biological substances during drying and the dried compositions derived therefrom. The compositions have improved storage stability.

Abstract translation: 本发明包括增加干燥过程中生物物质的稳定性的方法和由其衍生的干燥组合物。 组合物具有改善的储存稳定性。

公开(公告)号：US6034080A

公开(公告)日：2000-03-07

申请号：US205329

申请日：1998-12-04

Applicant: Camilo Colaco ,  Bruce Joseph Roser

Inventor： Camilo Colaco ,  Bruce Joseph Roser

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/047 ,  A61K31/155 ,  A61K31/47 ,  A61K31/665 ,  A61K31/70 ,  A61P25/28 ,  A61P43/00 ,  A61K31/535

CPC classification number: A61K31/155 ,  A61K31/00 ,  A61K31/7048

Abstract: Inhibitors of the Maillard reaction are useful in the treatment or prophylaxis of amyloidosis-based disease, particularly Alzheimer's disease. Particular examples include aminoguanidine and amphotericin B.

Abstract translation: 美拉德反应的抑制剂可用于治疗或预防基于淀粉样变性疾病，特别是阿尔茨海默氏病。 具体实例包括氨基胍和两性霉素B.

公开(公告)号：US5958455A

公开(公告)日：1999-09-28

申请号：US599273

申请日：1996-02-09

Applicant: Bruce J. Roser ,  Julian Blair ,  Camilo Colaco ,  Ross Henry Morris Hatley

Inventor： Bruce J. Roser ,  Julian Blair ,  Camilo Colaco ,  Ross Henry Morris Hatley

IPC: A61K9/20 ,  A61K9/14

CPC classification number: A61K9/2095 ,  A61K9/2018

Abstract: Methods of making tablets of a variety of physical forms are described. The tablets can be made into a wide variety of formulations. The invention further provides methods of making crystalline and amorphous anhydrous trehalose for use in formulating tablets suitable for use in dispensing pharmaceutical agents.

Abstract translation: 描述制备各种物理形式的片剂的方法。 片剂可制成各种制剂。 本发明还提供了制备结晶和无定形无水海藻糖的方法，用于配制适于用于分配药剂的片剂。

公开(公告)号：US5621094A

公开(公告)日：1997-04-15

申请号：US255565

申请日：1994-06-08

Applicant: Bruce J. Roser ,  Camilo Colaco

Inventor： Bruce J. Roser ,  Camilo Colaco

IPC: A61K47/26 ,  C08B37/00 ,  C12Q1/68 ,  C07G3/00 ,  C07G17/00 ,  C07H15/04

CPC classification number: A61K47/26 ,  C08B37/0039

Abstract: A method of preserving delicate biological substances or organic compounds (a) in a dry state and/or (b) at elevated temperatures and/or (c) under irradiation comprises incorporating in a system containing the said substances or compounds, a sugar or a sugar derivative selected from (i) a non-reducing glycoside of a polyhydroxy compound selected from sugar alcohols and other straight chain polyalcohols, or (ii) a non-reducing oligosaccharide selected from raffinose, stachyose and melezitose. In particular, methods for preserving dehydrated agarose gels comprising adding lactitol or glucopyranosyl-mannitol or glucopyranosyl-sorbitol to the gel during formation and prior to dehydration are disclosed.

Abstract translation: 在干燥状态和/或（b）在高温和/或（c）照射下保存微生物物质或有机化合物（a）的方法包括在含有所述物质或化合物的体系中加入糖或 选自（i）选自糖醇和其它直链多元醇的多羟基化合物的非还原性糖苷的糖衍生物，或（ii）选自棉子糖，水苏糖和松三糖的非还原性寡糖。 特别地，公开了用于保存脱水琼脂糖凝胶的方法，其包括在形成期间和脱水之前将凝胶中的乳糖醇或吡喃葡萄糖基甘露糖醇或吡喃葡萄糖基 - 山梨醇加入到凝胶中。