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    Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
    33.
    发明授权
    Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them 有权
    五氟硫烷基苯甲酰胍胺，其制备方法，用作药物或诊断助剂，以及包含它们的药物

    公开(公告)号：US07375138B2

    公开(公告)日：2008-05-20

    申请号：US10429810

    申请日：2003-05-05

    Applicant: Heinz-Werner Kleemann

    Inventor： Heinz-Werner Kleemann

    IPC: A61K31/65 ,  C07C309/00

    CPC classification number: C07C381/00 ,  Y10S514/821

    Abstract: Pentafluorosulfanylbenzoylguanidines of the formula I and II in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

    Abstract translation: 其中R 1至R 4具有权利要求中所述含义的式I和II的五氟硫烷基苯甲酰基胍适合作为具有用于预防梗死和治疗梗死和用于治疗心绞痛的心脏保护组分的抗心律失常药物。 它们还预防性地抑制与缺血诱导的损伤的发展相关的病理生理过程，特别是在引发缺血诱发的心律失常中。

    Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
    36.
    发明授权
    Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权
    具有杂芳基磺酰侧链的邻氨基苯甲酰胺，制备方法和用途

    公开(公告)号：US07235664B2

    公开(公告)日：2007-06-26

    申请号：US11052959

    申请日：2005-02-08

    Applicant: Joachim Brendel ,  Thomas Boehme ,  Stefan Peukert ,  Heinz-Werner Kleemann

    Inventor： Joachim Brendel ,  Thomas Boehme ,  Stefan Peukert ,  Heinz-Werner Kleemann

    IPC: C07D215/36 ,  A61K31/47

    CPC classification number: C07D261/10 ,  A61K31/47 ,  A61K45/06 ,  C07D215/36 ,  C07D217/02 ,  C07D271/12 ,  C07D333/34 ,  C07D401/12 ,  C07D405/12 ,  A61K2300/00

    Abstract: This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.

    Abstract translation: 本发明包括具有杂芳基磺酰侧链的邻氨基苯甲酰胺，其制备方法，它们作为药物或诊断助剂的用途，以及含有它们的药物制剂。 其中R 1至R 7具有权利要求中所述含义的式I化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流剂的钾电流 。 因此，它们适合作为新的抗心律失常成分，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。

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