摘要:
A process for the preparation of a mixture comprising a compound of formula (1) and a compound of formula (2) wherein R1 is an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl, optionally substituted C5-7 cycloalkyl or optionally substituted benzyl, R2 is an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl or optionally substituted C5-7 cycloalkyl, A is either S or NR3, R3 is an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl or optionally substituted C5-7 cycloalkyl, or R2 and R3 together form a 5-7 membered ring which can contain an oxygen atom, R4 is hydrogen or methyl, R5 is an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl, optionally substituted C5-7 cycloalkyl or optionally substituted benzyl and, R6 is hydrogen or an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl or optionally substituted C5-7 cycloalkyl, or R5 and R6 together form a 5-7 membered ring which can contain an oxygen atom, which comprises reacting in an alkaline or base medium a compound of formula (3) wherein X− is an anion, R1, R2, R3, R4, R5 and R6 have the same meaning as above, A+ is S+ or N+R3.
摘要:
This invention relates to fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. An embodiment of the invention embraces compounds of the formula I: and the pharmaceutically tolerated salts thereof. The disclosed compounds are valuable inhibitors of the cellular sodium/proton exchanger (Na+ /H+ exchanger) . They are therefore outstandingly suitable for the treatment of all diseases attributable to increased Na+ /H+ exchange.
摘要翻译:本发明涉及氟苯基取代的烯基羧酸胍,其制备方法,它们作为药物或诊断剂的用途,以及含有它们的药物。 本发明的一个实施方案包括式I化合物及其药学上可耐受的盐。 所公开的化合物是细胞钠/质子交换剂(Na + / H +交换剂)的有价值的抑制剂。 因此,它们非常适合用于治疗由于增加的Na + / H +交换而引起的所有疾病。
摘要:
Use of phenethylacrylamides of the formula I: in which the substituents have the following meanings: X is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy and —O—C(Ra,Rb)—C≡C—R6; Ra,Rb and Rc have the meanings given in the description; m,n independently of one another are 1 to 4, it being possible for the radicals X or Y to be different if m or n is greater than 1; Y is halogen, nitro, cyano, alkyl, CF3, alkoxy and phenyl; R1,R2 independently of one another are hydrogen, halogen, alkyl, alkoxy, haloalkoxy and CF3; R3,R4,R5,R6 independently of one another are hydrogen, halogen, alkyl, alkoxy, or R3 and R4 together form a cyclopropyl ring, it being possible for the C—R5— and C—R6 bonds can be in the E- or Z-position relative to each other; for controlling phytopathogenic fungal pests, novel phenethylacrylamides, their preparation, and compositions comprising them.
摘要翻译:使用式I的苯乙基丙烯酰胺:其中取代基具有以下含义:X是卤素,烷基,卤代烷基,烷氧基,卤代烷氧基和-OC(R a,R b)-C = CR 6; R a,R b和R c具有说明书中给出的含义; m,n彼此独立地为1至4,如果m或n可以使基团X或Y不同 大于1; Y是卤素,硝基,氰基,烷基,CF 3,烷氧基和苯基; R 1,R 2彼此独立地是氢,卤素,烷基,烷氧基,卤代烷氧基和CF 3; R 3 R 4,R 5,R 6彼此独立地是氢,卤素,烷基,烷氧基或R 3和R 4一起形成环丙基环,其中CR <5> - 和CR 6键可以相对于彼此位于E-或Z-位;用于控制植物病原性真菌害虫,新型苯乙基丙烯酰胺,它们的制备和包含它们的组合物。
摘要:
The present invention relates to novel acrylate-type N-methyl E-2-(2-methylphenyl)oxymethyl)-6-methylphenyl-glyoxylamide O-methyl oxime represented by formula (1), its preparation method and its use as fungicides. The compound of the present invention has not only stronger fungicidal effect on plant pathogens at low concentrations but also broader fungicidal spectrum than the conventional fungicides. Especially, because the compound has excellent systemic and curative effect as well as no toxicity, it can be used as an efficacious agricultural fungicide. In addition, the compound of the present invention can be useful as environmental-friendly fungicide capable of causing less environmental pollution fungicide due to its strong fungicidal effect at low concentrations.
摘要:
Substantive UV-absorbing water-soluble quaternary salts of cinnamidoalkylamine of formula I. Hair, skin and fabric care compositions containing the compounds of formula I; wherein R1 represents up to four substituents, same or different, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing up to 6 carbon atoms, alkoxy groups containing up to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing up to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing up to 6 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing up to 6 carbon atoms; n is an integer from 1 to 6; m is an integer from 1 to 10; X− is a counter anion of quaternary centres selected from halides including chloride, bromide, iodide and methane sulphonate and its derivatives such as trifluoro methane sulphonate, benzene sulphonates including its p-bromo, nitro and methyl derivative.