公开(公告)号：US07729603B2

公开(公告)日：2010-06-01

申请号：US11219410

申请日：2005-09-02

Applicant: Jing Xu ,  Roman C. Gutierrez ,  Tony K. Tang

Inventor： Jing Xu ,  Roman C. Gutierrez ,  Tony K. Tang

IPC: G03B3/00 ,  G03B13/00 ,  G02B5/04

CPC classification number: G03B13/36 ,  G03B3/02 ,  G03B29/00 ,  H04N5/23212

Abstract: A method and system for enhancing the resolution of a camera are disclosed. For example, a single lens can be placed at a predetermined position and the position of a lens assembly can be adjusted so as to enhance the resolution of the camera. The single lens can then be moved so as to effect focusing of the camera while the position of the lens assembly tends to maintain enhanced resolution thereof.

Abstract translation: 公开了一种用于提高照相机分辨率的方法和系统。 例如，可以将单个透镜放置在预定位置，并且可以调整透镜组件的位置，以便提高照相机的分辨率。 然后可以移动单个透镜以便实现相机的聚焦，同时透镜组件的位置倾向于保持增强的分辨率。

公开(公告)号：US20100098716A1

公开(公告)日：2010-04-22

申请号：US12555743

申请日：2009-09-08

Applicant: Haitao WANG ,  Chungsheng Mao ,  Jizhi Li ,  Jing XU ,  Rui ZHANG ,  Ling Wang ,  DU Yong ,  Longbin LIU

Inventor： Haitao WANG ,  Chungsheng Mao ,  Jizhi Li ,  Jing XU ,  Rui ZHANG ,  Ling Wang ,  DU Yong ,  Longbin LIU

IPC: A61K39/395 ,  A61K38/00

CPC classification number: C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

Abstract translation: 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

公开(公告)号：US07660056B1

公开(公告)日：2010-02-09

申请号：US12030704

申请日：2008-02-13

Applicant: Tony K. Tang ,  Roman C. Gutierrez ,  Robert J. Calvet ,  Jing Xu ,  Eric R. Fossum

Inventor： Tony K. Tang ,  Roman C. Gutierrez ,  Robert J. Calvet ,  Jing Xu ,  Eric R. Fossum

IPC: G02B7/02

CPC classification number: G03B7/083 ,  G02B7/08 ,  G02B13/001 ,  G03B3/10 ,  G03B17/02

Abstract: An improved lens barrel and related methods are provided. For example, in accordance with an embodiment of the present invention, a lens barrel includes a housing comprising a first section having a first diameter and a second section having a second diameter. A first lens element having a diameter approximately equal to the first diameter of the first section is enclosed by the first section of the housing. A second lens element is provided having a diameter approximately equal to the second diameter of the second section.

Abstract translation: 提供了改进的镜筒和相关方法。 例如，根据本发明的实施例，透镜镜筒包括壳体，该壳体包括具有第一直径的第一部分和具有第二直径的第二部分。 具有大致等于第一部分的第一直径的直径的第一透镜元件被壳体的第一部分包围。 提供第二透镜元件，其具有大致等于第二部分的第二直径的直径。

公开(公告)号：US20100025110A1

公开(公告)日：2010-02-04

申请号：US12511456

申请日：2009-07-29

Applicant: Hendrik John ,  Joachim F. Oppelt ,  Jing Xu

Inventor： Hendrik John ,  Joachim F. Oppelt ,  Jing Xu

IPC: E21B44/00 ,  E21B44/02 ,  E21B7/00

CPC classification number: E21B44/00

Abstract: A system for monitoring and controlling a load on a downhole component of a well drilling system is disclosed. The system includes: a downhole tool disposed in a drillstring and configured to be movable within a borehole, the drillstring configured to allow a drilling fluid to be advanced therethrough and into the borehole; at least one sensor disposed within the downhole tool for in-situ measurement of at least one physicochemical property of an environment surrounding the downhole tool; and a processor configured to monitor the at least one physicochemical property and at least one of i) provide physicochemical property information to a user during a drilling/steering operation, ii) adjust a load on the downhole component based on the environment information and iii) shut down the system in response to a detection of a measured physicochemical property beyond a selected threshold.

Abstract translation: 公开了一种用于监测和控制钻井系统的井下部件上的负载的系统。 该系统包括：井下工具，其布置在钻柱中并且构造成可在钻孔内移动，所述钻柱构造成允许钻井流体通过其进入钻孔; 设置在所述井下工具内的至少一个传感器，用于原位测量围绕所述井下工具的环境的至少一个物理化学性质; 以及处理器，被配置为监测所述至少一个物理化学性质，并且i）在钻井/转向操作期间向用户提供物理化学性质信息，ii）基于所述环境信息调整所述井下部件上的载荷，以及iii） 响应于超出选定阈值的测量物理化学性质的检测来关闭系统。

公开(公告)号：US20090103440A1

公开(公告)日：2009-04-23

申请号：US11977228

申请日：2007-10-23

Applicant: Haifeng Wang ,  Bin Chen ,  Bin Wang ,  Jing Xu ,  Ting Zhou

Inventor： Haifeng Wang ,  Bin Chen ,  Bin Wang ,  Jing Xu ,  Ting Zhou

IPC: G06F11/30

CPC classification number: H04W72/1257 ,  H04L1/1812 ,  H04L1/1887 ,  H04L1/1893 ,  H04W72/04

Abstract: Disclosed is a method the includes determining if a collision will occur between a transmission from a first user equipment that uses a persistently assigned uplink resource (such as for VoIP packet transmissions) and a retransmission from a second user equipment that uses a synchronous non-adaptive automatic repeat request procedure (e.g., synchronous, non-adaptive HARQ). If it is determined that a collision will occur, the method dynamically allocates the first user equipment to another uplink resource to avoid the collision, while if it is determined that the collision will not occur, the first user equipment is not dynamically allocated another uplink resource so that the first user equipment sends its transmission using the persistently assigned uplink resource. The embodiments of this invention pertain to both the base station (e.g., an evolved Node-B) and the user equipment.

Abstract translation: 公开了一种方法，其包括确定在使用持续分配的上行链路资源（例如用于VoIP分组传输）的第一用户设备的传输与来自使用同步非自适应的第二用户设备的重传之间是否发生冲突 自动重发请求过程（例如，同步，非自适应HARQ）。 如果确定发生冲突，则该方法动态地将第一用户设备分配给另一上行资源以避免冲突，而如果确定不发生冲突，则第一用户设备不是动态地分配另一个上行资源 使得第一用户设备使用持续分配的上行链路资源发送其传输。 本发明的实施例涉及基站（例如，演进节点B）和用户设备。

公开(公告)号：US20090096221A1

公开(公告)日：2009-04-16

申请号：US11972630

申请日：2008-01-11

Applicant: TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  JIAN-JUN LI ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  BING-JING XU

Inventor： TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  JIAN-JUN LI ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  BING-JING XU

IPC: E05C19/06

CPC classification number: H05K5/0221 ,  Y10S292/37 ,  Y10T292/082 ,  Y10T292/0829 ,  Y10T292/0895

Abstract: An exemplary latching mechanism (20) includes a base (22) having two resilient claps (224), a detachable portion (24) having two resilient clasps (244) for engaging with the hooking portions of the base, and an unlatching element (25). The unlatching element defines two engaging slots (258) and is disposed between the base and the detachable portion. The resilient clasps of the detachable portion engage with the hooking portions of the base when the detachable portion is pressed to be latched to the base. The resilient clasps engage in the engaging slots of the unlatching element when the detachable portion is pressed to be detached from the base. Then the detachable portion and the unlatching element together move away from the base. The engagement of the detachable portion and unlatching element makes the at least one resilient clasp deforms and thus disengages from the at least one hooking portion of the base.

Abstract translation: 示例性的闭锁机构（20）包括具有两个弹性弹簧（224）的基座（22），具有两个弹性卡扣（244）的可拆卸部分（24），用于与基座的钩挂部分接合，以及解锁元件 ）。 解锁元件限定两个接合槽（258）并且设置在基座和可拆卸部分之间。 当可拆卸部分被按压以锁定到基座时，可拆卸部分的弹性扣环与底座的钩部接合。 当可拆卸部分被按压以与基部分离时，弹性扣件接合解锁元件的接合槽。 然后可拆卸部分和解锁元件一起从基座移开。 可拆卸部分和解锁元件的接合使得至少一个弹性扣环变形并因此与基座的至少一个钩挂部分分离。

公开(公告)号：US20090094808A1

公开(公告)日：2009-04-16

申请号：US11972629

申请日：2008-01-11

Applicant: TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  JIAN-JUN LI ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  BING-JING XU

Inventor： TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  JIAN-JUN LI ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  BING-JING XU

IPC: A44B21/00

CPC classification number: E05C19/022 ,  Y10T24/45414 ,  Y10T292/082 ,  Y10T292/0829

Abstract: An exemplary latching mechanism (20) includes a base (22), a detachable portion (24), a rotatable wheel (25), and a resilient member (28). The base has two resilient hooks (224). The detachable portion has two clasping portion (244) for engaging with the resilient hooks. The rotatable wheel has a plurality of hook openers (256) and is rotatable between two states forced by the detachable portion. The resilient member is disposed between the base and detachable portion for providing elastic force. The at least one clasping portion of the detachable portion engages with the at least one resilient hook of the base and the rotatable wheel is at a second state. The rotatable wheel is rotated to a first state and the at least one resilient hook are pushed to deform by at least one of the hook openers of the rotatable wheel.

Abstract translation: 示例性的闭锁机构（20）包括底座（22），可拆卸部分（24），可旋转轮（25）和弹性构件（28）。 底座有两个弹性钩（224）。 可拆卸部分具有用于与弹性钩接合的两个夹紧部分（244）。 可旋转轮具有多个钩开口（256），并且可在由可拆卸部分强制的两个状态之间旋转。 弹性构件设置在基部和可拆卸部分之间，用于提供弹性力。 可拆卸部分的至少一个紧固部分与基部的至少一个弹性钩接合，并且可旋转轮处于第二状态。 可旋转轮旋转到第一状态，并且至少一个弹性钩被可旋转轮的至少一个钩开启器推动变形。

公开(公告)号：US20090090719A1

公开(公告)日：2009-04-09

申请号：US12118681

申请日：2008-05-10

Applicant: TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  JIAN-JUN LI ,  BING-JING XU

Inventor： TE-SHENG JAN ,  YU-TAO CHEN ,  CHUN-CHE YEN ,  GANG CHENG ,  ZHENG-QIANG SONG ,  MENG-HUA HE ,  JIAN-JUN LI ,  BING-JING XU

IPC: B65D45/16 ,  B65D45/00

CPC classification number: B65D43/021 ,  B65D2543/00574

Abstract: An exemplary lid lock mechanism (20) includes a main body (22) and a lid (24). Two resilient hooks (222) and two resisting portions (224) are formed on an inner surface of the main body. The lid includes a lid cap (242). Two hooking portions (246) and two extending pieces (248) are formed on a surface (244) of the lid cap. The hooking portions are engaged with the resilient hooks of the main body when the lid is connected to the main body. To detach the lid from the main body, the hooks of the hooking portions are disengaged from the resilient hooks of the main body.

Abstract translation: 示例性的盖锁定机构（20）包括主体（22）和盖（24）。 在主体的内表面上形成有两个弹性钩（222）和两个阻力部（224）。 盖子包括盖帽（242）。 在盖帽的表面（244）上形成有两个钩部（246）和两个延伸件（248）。 当盖连接到主体时，钩部与主体的弹性钩接合。 为了从主体分离盖子，钩挂部分的钩与主体的弹性钩脱离。

公开(公告)号：US20090081218A1

公开(公告)日：2009-03-26

申请号：US12180455

申请日：2008-07-25

Applicant: Haitao WANG ,  Yong DU ,  Rui ZHANG ,  Jing XU ,  Longbin LIU

Inventor： Haitao WANG ,  Yong DU ,  Rui ZHANG ,  Jing XU ,  Longbin LIU

IPC: A61K39/395 ,  C07K16/18 ,  C12N9/50 ,  C07H21/04 ,  C12P21/04 ,  C12N5/06

CPC classification number: C12N15/62 ,  A61K47/6811 ,  A61K47/6835 ,  C07K2317/53 ,  C07K2319/30

Abstract: A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.

Abstract translation: 提供了具有非免疫球蛋白多肽的融合蛋白，其具有接近其C末端的半胱氨酸残基和具有突变的铰链区的免疫球蛋白组分。 该突变包括位于位于最接近非Ig组分的半胱氨酸残基的半胱氨酸残基的天然铰链区的位置的点突变位点。 与非免疫球蛋白多肽的半胱氨酸残基和突变的铰链区的任何剩余半胱氨酸残基的距离足以防止其间形成二硫键。

公开(公告)号：US20080312148A1

公开(公告)日：2008-12-18

申请号：US11764786

申请日：2007-06-18

Applicant: Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

Inventor： Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

IPC: A61K38/21 ,  A61P35/00 ,  C07K14/00 ,  C12N1/19 ,  C12N1/21 ,  C12N15/11 ,  C12N15/63 ,  C12N5/10

CPC classification number: C07K14/56 ,  A61K38/00 ,  C07K14/555

Abstract: This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.

Abstract translation: 本申请涉及重组人类干扰素样蛋白。 在一个实施方案中，与天然存在的人干扰素α2b（HuIFN-α2b）相比，描述了通过基因改组技术产生的重组蛋白质具有增强的抗病毒和抗增殖活性。 本发明包括编码蛋白质的多核苷酸和包含多核苷酸的重组载体和宿主细胞。 优选地，多核苷酸选自各自具有与SEQ ID：No.1至少93％相同的序列的多核苷酸，并且所述蛋白质选自蛋白质组，其各自具有与SEQ ID NO：至少85％相同的氨基酸序列 否：2.包含蛋白质的蛋白质和组合物可用于治疗对干扰素治疗（例如病毒性疾病和癌症）有反应的病症。