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公开(公告)号：US06232307B1
公开(公告)日：2001-05-15
申请号：US09416078
申请日：1999-10-12
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61K3155
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物，以及使用这些化合物的药物组合物和治疗方法，其具有一般性 结构如下：
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公开(公告)号：US5932743A
公开(公告)日：1999-08-03
申请号：US124348
申请日：1998-07-29
Applicant: Michael D. Collini , John W. Ellingboe
Inventor： Michael D. Collini , John W. Ellingboe
IPC: C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/22 , C07D209/24 , C07D209/10
CPC classification number: C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/22 , C07D209/24
Abstract: The present invention relates to novel substituted indole compounds of formula (I) ##STR1## having pharmacological activity, to processes for their preparation, to solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.
Abstract translation: 本发明涉及具有药理学活性的式（I）的取代吲哚化合物，其制备方法，制备化合物文库的固相方法，利用化合物用于药物发现的文库及其药物组合物 。
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33.发明授权2-phenyl-1-�4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents 失效2-苯基-1- [4-（氨基-1-基 - 烷-1-基） - 苄基] -1H-吲哚-5-醇作为雌激素剂
公开(公告)号：US5880137A
公开(公告)日：1999-03-09
申请号：US69042
申请日：1998-04-29
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran
IPC: C07D209/08 , C07D209/12 , C07D401/06 , A61K31/44 , A61K31/445
CPC classification number: C07D209/08 , C07D209/12
Abstract: The present invention relates to new 2-Phenyl-1-�4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structure below. ##STR1##
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（氨基-1-基 - 烷-1-炔基） - 苄基] -1H-吲哚-5-醇化合物，以及 药物组合物和使用这些化合物的治疗方法，其具有下面的一般结构。
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