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![2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents](/abs-image/US/2004/09/07/US06787538B2/abs.jpg.150x150.jpg)
1.发明授权2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents 有权2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚作为雌激素剂公开(公告)号：US06787538B2
公开(公告)日：2004-09-07
申请号：US10617096
申请日：2003-07-10
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61P530
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in providing hormone replacement therapy.
Abstract translation: 本发明涉及具有以下一般结构的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚类化合物：其可用于提供激素替代疗法。
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![Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols](/abs-image/US/2003/03/25/US06537971B2/abs.jpg.150x150.jpg)
公开(公告)号：US06537971B2
公开(公告)日：2003-03-25
申请号：US10087349
申请日：2002-03-01
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Anita Wai-Yin Chan , Arkadiy Z. Rubezhov
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Anita Wai-Yin Chan , Arkadiy Z. Rubezhov
IPC: A61K3170
CPC classification number: C07H17/02
Abstract: This invention provides tissue selective estrogens of formula I having the structure wherein: R1 and R2 are independently, hydrogen, alkyl chain of 1-6 carbon atoms, benzyl, acyl of 2-7 carbon atoms, benzoyl, X is hydrogen, alkyl of 1-6 carbon atoms, CN, halogen, trifluoromethyl, or thioalkyl of 1-6 carbon atoms; n=1-3; with the proviso that at least one of R1 or R2 are not hydrogen, alkyl chain of 1-6 carbon atoms, benzyl, acyl of 2-7 carbon atoms, or benzoyl; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US6069153A
公开(公告)日：2000-05-30
申请号：US306072
申请日：1999-05-06
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran
IPC: C07D209/80 , C07D209/94 , A61K31/445 , A61K31/40 , A61K31/55 , C07D401/12 , C07D403/12
CPC classification number: C07D209/80 , C07D209/94
Abstract: The present invention relates to new substituted benzo[a]carbozoles and indenoindoles which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, having the general structures below. ##STR1##
Abstract translation: 本发明涉及可用作雌激素剂的新的取代的苯并[a]碳唑和茚并吲哚，以及具有以下一般结构的药物组合物和利用这些化合物的治疗方法。
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4.发明授权2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents 失效2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚作为雌激素剂
公开(公告)号：US5998402A
公开(公告)日：1999-12-07
申请号：US833271
申请日：1997-04-04
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61K31/404 , A61P3/06 , A61P5/00 , A61P5/30 , A61P13/08 , A61P19/10 , A61P35/00 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D403/12 , C07D405/04 , C07D405/12 , A61K31/40 , C07D209/04 , C07D403/00 , C07D411/00
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: ##STR1##
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物，以及使用这些化合物的药物组合物和治疗方法，其具有一般性 结构如下：
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![2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents](/abs-image/US/2001/12/04/US06326367B1/abs.jpg.150x150.jpg)
5.发明授权2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents 有权2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚作为雌激素剂公开(公告)号：US06326367B1
公开(公告)日：2001-12-04
申请号：US09388581
申请日：1999-09-02
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61P3500
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物，以及使用这些化合物的药物组合物和治疗方法，其具有一般 结构如下：
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Patent Agency Ranking
公开(公告)号：US06232307B1
公开(公告)日：2001-05-15
申请号：US09416078
申请日：1999-10-12
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61K3155
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物，以及使用这些化合物的药物组合物和治疗方法，其具有一般性 结构如下：
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7.发明授权3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as estrogenic agents 失效3- [4-（2-苯基 - 吲哚-1-基甲基）苯基] - 丙烯酰胺作为雌激素剂
公开(公告)号：US5985910A
公开(公告)日：1999-11-16
申请号：US837129
申请日：1997-04-14
Applicant: Chris P. Miller , Bach D. Tran
Inventor： Chris P. Miller , Bach D. Tran
IPC: C07D209/10 , C07D209/12 , A61K31/165 , C07D209/04 , C07D209/18 , C07D233/10
CPC classification number: C07D209/10 , C07D209/12
Abstract: The present invention relates to new 3-[4-(2-Phenyl-Indole-1-ylmethyl)-Phenyl]-Acrylamide compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, the compounds having the following general structure. ##STR1##
Abstract translation: 本发明涉及可用作雌激素剂的新的3- [4-（2-苯基 - 吲哚-1-基甲基） - 苯基] - 丙烯酰胺化合物，以及使用这些化合物的药物组合物和治疗方法，化合物 具有以下一般结构。
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8.发明授权2-phenyl-1-�4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents 失效2-苯基-1- [4-（氨基-1-基 - 烷-1-基） - 苄基] -1H-吲哚-5-醇作为雌激素剂
公开(公告)号：US5880137A
公开(公告)日：1999-03-09
申请号：US69042
申请日：1998-04-29
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran
IPC: C07D209/08 , C07D209/12 , C07D401/06 , A61K31/44 , A61K31/445
CPC classification number: C07D209/08 , C07D209/12
Abstract: The present invention relates to new 2-Phenyl-1-�4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structure below. ##STR1##
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（氨基-1-基 - 烷-1-炔基） - 苄基] -1H-吲哚-5-醇化合物，以及 药物组合物和使用这些化合物的治疗方法，其具有下面的一般结构。
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![2-phenyl-1-[4(2-aminoethoxy)-benzyl]-indoles as estrogenic agents](/abs-image/US/2004/12/28/US06835729B2/abs.jpg.150x150.jpg)
9.发明授权2-phenyl-1-[4(2-aminoethoxy)-benzyl]-indoles as estrogenic agents 有权2-苯基-1- [4（2-氨基乙氧基） - 苄基] - 吲哚作为雌激素剂公开(公告)号：US06835729B2
公开(公告)日：2004-12-28
申请号：US10720504
申请日：2003-11-24
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61P306
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in lowering cholesterol levels.
Abstract translation: 本发明涉及具有以下一般结构的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物：其可用于降低胆固醇水平。
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10.发明授权Tissue selective compounds in the treatment of prostate cancer or benign prostate hypertrophy 有权组织选择性化合物治疗前列腺癌或良性前列腺肥大公开(公告)号：US06225308B1
公开(公告)日：2001-05-01
申请号：US09416318
申请日：1999-10-12
Applicant: Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
Inventor： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC: A61K3140
CPC classification number: C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:
Abstract translation: 本发明涉及可用作雌激素剂的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚化合物，以及使用这些化合物的药物组合物和治疗方法，其具有一般性 结构如下：
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