公开(公告)号：US09857375B2

公开(公告)日：2018-01-02

申请号：US14436338

申请日：2013-09-26

Applicant: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY

Inventor： Noboru Konishi ,  Keiji Shimada

IPC: G01N33/574 ,  A61K45/06 ,  A61K31/713 ,  C12Q1/68

CPC classification number: G01N33/57488 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57411 ,  G01N2333/4703

Abstract: The present invention provides a novel cancer marker that is useful in the diagnosis of urothelial cancer. The present invention uses ubiquilin 2 as a cancer marker for urothelial cancer (renal pelvis cancer, ureteral cancer, and bladder cancer). Detection of ubiquilin 2 in a urine sample allows easy and accurate diagnosis of a possibility of urothelial cancer. The present invention is also applicable to the diagnosis of squamous cancer (esophageal cancer, cervical cancer, etc.).

公开(公告)号：US08897862B2

公开(公告)日：2014-11-25

申请号：US13951274

申请日：2013-07-25

Applicant: Public University Corporation Nara Medical University ,  Kinki University

Inventor： Hiroshi Kobayashi ,  Toshiyuki Sado ,  Hisashi Yoshida

IPC: A61B5/04 ,  A61B5/024 ,  A61B5/0444 ,  A61B5/00

CPC classification number: A61B5/02411 ,  A61B5/04286 ,  A61B5/0444 ,  A61B5/4362 ,  A61B5/6823 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7271

Abstract: A non-transitory computer-readable recording medium storing a computer program, the computer program comprising: a selecting module configured to select, from among a plurality of biopotential signals, a biopotential signal containing a high proportion of a maternal cardiac potential signal component; an independent component analysis module configured to perform independent component analysis on the plurality of biopotential signals; a periodic signal detection module configured to detect, as a first peak time signal, a signal having periodic peaks from a biopotential signal and to detect, as second peak time signals, one or more signals having periodic peaks among signals output from the independent component analysis module; and an output signal selecting module configured to select from among the one or more second peak time signals a signal having peak times different from those of the first peak time signal.

Abstract translation: 一种存储计算机程序的非暂时计算机可读记录介质，所述计算机程序包括：选择模块，被配置为从多个生物电位信号中选择含有高比例母体心脏电位信号分量的生物电位信号; 独立分量分析模块，被配置为对所述多个生物电位信号执行独立分量分析; 周期性信号检测模块，被配置为检测具有来自生物电位信号的周期性峰值的信号作为第一峰值时间信号，并且检测作为第二峰值时间信号的一个或多个具有从独立分量分析输出的信号中具有周期性峰值的信号 模块 以及输出信号选择模块，被配置为从所述一个或多个第二峰值时间信号中选择具有与所述第一峰值时间信号不同的峰值时间的信号。

公开(公告)号：US20130310701A1

公开(公告)日：2013-11-21

申请号：US13951274

申请日：2013-07-25

Applicant: KINKI UNIVERSITY ,  PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY

Inventor： Hiroshi KOBAYASHI ,  Toshiyuki SADO ,  Hisashi YOSHIDA

IPC: A61B5/024

CPC classification number: A61B5/02411 ,  A61B5/04286 ,  A61B5/0444 ,  A61B5/4362 ,  A61B5/6823 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7271

Abstract: A non-transitory computer-readable recording medium storing a computer program, the computer program comprising: a selecting module configured to select, from among a plurality of biopotential signals, a biopotential signal containing a high proportion of a maternal cardiac potential signal component; an independent component analysis module configured to perform independent component analysis on the plurality of biopotential signals; a periodic signal detection module configured to detect, as a first peak time signal, a signal having periodic peaks from a biopotential signal and to detect, as second peak time signals, one or more signals having periodic peaks among signals output from the independent component analysis module; and an output signal selecting module configured to select from among the one or more second peak time signals a signal having peak times different from those of the first peak time signal.

Abstract translation: 一种存储计算机程序的非暂时计算机可读记录介质，所述计算机程序包括：选择模块，被配置为从多个生物电位信号中选择含有高比例母体心脏电位信号分量的生物电位信号; 独立分量分析模块，被配置为对所述多个生物电位信号执行独立分量分析; 周期性信号检测模块，被配置为检测具有来自生物电位信号的周期性峰值的信号作为第一峰值时间信号，并且检测作为第二峰值时间信号的一个或多个具有从独立分量分析输出的信号中具有周期性峰值的信号 模块 以及输出信号选择模块，被配置为从所述一个或多个第二峰值时间信号中选择具有与所述第一峰值时间信号不同的峰值时间的信号。

公开(公告)号：US20130109982A1

公开(公告)日：2013-05-02

申请号：US13718413

申请日：2012-12-18

Applicant: Omron Healthcare Co., Ltd. ,  Public University Corporation Nara Medical University

Inventor： Hironori SATO ,  Naoki MORI ,  Tomoko HASHIMOTO ,  Toshihiko OGURA ,  Shozo TAKAMATSU ,  Hideo UTSUNO ,  Kimihiko KICHIKAWA ,  Hirofumi ITO

IPC: A61B5/024 ,  A61B5/00

CPC classification number: A61B5/02438 ,  A61B5/02014 ,  A61B5/02444 ,  A61B5/0285 ,  A61B5/0295 ,  A61B5/6824 ,  A61B5/6829 ,  A61B5/7225 ,  A61B5/7246

Abstract: A first calculation unit receives phase characteristics Pa(f) and Pb(f) outputted from frequency transform units, calculates a propagation time difference based on a phase difference between the two phase characteristics in a high-frequency component thereof, and calculates a pulse wave velocity by dividing a difference in the distances of vascular pathways from the heart to respective measurement areas. Meanwhile, a second calculation unit calculates a pulse wave velocity by dividing the stated difference in the distances by a appearance time difference at a predetermined position in respective pulse waveforms obtained by rendering the measurement signals Pa(t) and Pb(t) on a time axis. A comparison unit compares the pulse wave velocities, and in the case where the ratio thereof is outside a predetermined range, an evaluation result indicating that it is possible that a predetermined pathologic change is present in the vascular pathway is outputted to a display processing unit.

Abstract translation: 第一计算单元接收从频率变换单元输出的相位特性Pa（f）和Pb（f），基于其高频分量中的两相特性之间的相位差计算传播时间差，并计算脉波 通过将心脏的血管通路的距离的差除以相应的测量区域来实现。 同时，第二计算单元通过将所述距离的差除以在一定时间内通过使测量信号Pa（t）和Pb（t）在时间上得到的各个脉搏波形中的出现时间差来计算脉搏波速度 轴。 比较单元比较脉搏波速度，并且在比例超出预定范围的情况下，指示可能在血管通路中存在预定病理变化的评估结果被输出到显示处理单元。