公开(公告)号：US06908919B2

公开(公告)日：2005-06-21

申请号：US10195573

申请日：2002-07-15

Applicant: Michael S. South ,  Brenda L. Case ,  Thomas A. Dice ,  Ricky L. Fenton ,  Gary W. Franklin ,  Michael J. Hayes ,  Horng-Chih Huang ,  Wei Huang ,  Darin E. Jones ,  Carrie L. Kusturin ,  Richard J. Lindmark ,  Scott A. Long ,  William L. Neumann ,  David B. Reitz ,  John I. Trujillo ,  Ching-Cheng Wang ,  Rhonda Wood ,  Qingping Zeng ,  Matthew W. Mahoney ,  John J. Parlow ,  Melvin L. Rueppel

Inventor： Michael S. South ,  Brenda L. Case ,  Thomas A. Dice ,  Ricky L. Fenton ,  Gary W. Franklin ,  Michael J. Hayes ,  Horng-Chih Huang ,  Wei Huang ,  Darin E. Jones ,  Carrie L. Kusturin ,  Richard J. Lindmark ,  Scott A. Long ,  William L. Neumann ,  David B. Reitz ,  John I. Trujillo ,  Ching-Cheng Wang ,  Rhonda Wood ,  Qingping Zeng ,  Matthew W. Mahoney ,  John J. Parlow ,  Melvin L. Rueppel

IPC: A61K38/00 ,  C07D241/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06 ,  C07K5/078 ,  A61K31/495 ,  A61P7/02

CPC classification number: C07D401/12 ,  A61K38/00 ,  C04B35/632 ,  C07D241/20 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06139 ,  C07K5/06191

Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

Abstract translation: 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

公开(公告)号：US20050043313A1

公开(公告)日：2005-02-24

申请号：US10940693

申请日：2004-09-14

Applicant: Michael South ,  Brenda Case ,  Thomas Dice ,  Ricky Fenton ,  Gary Franklin ,  Michael Hayes ,  Horng-Chih Huang ,  Wei Huang ,  Darin Jones ,  Carrie Kusturin ,  Richard Lindmark ,  Scott Long ,  William Neumann ,  David Reitz ,  John Trujillo ,  Ching-Cheng Wang ,  Rhonda Wood ,  Qingping Zeng ,  Matthew Mahoney ,  John Parlow ,  Melvin Rueppel

Inventor： Michael South ,  Brenda Case ,  Thomas Dice ,  Ricky Fenton ,  Gary Franklin ,  Michael Hayes ,  Horng-Chih Huang ,  Wei Huang ,  Darin Jones ,  Carrie Kusturin ,  Richard Lindmark ,  Scott Long ,  William Neumann ,  David Reitz ,  John Trujillo ,  Ching-Cheng Wang ,  Rhonda Wood ,  Qingping Zeng ,  Matthew Mahoney ,  John Parlow ,  Melvin Rueppel

IPC: A61K38/00 ,  C07D241/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06 ,  C07K5/078 ,  A61K31/4965 ,  A61K31/497 ,  C07D43/02

CPC classification number: C07D401/12 ,  A61K38/00 ,  C04B35/632 ,  C07D241/20 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06139 ,  C07K5/06191

Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.