公开(公告)号：US06521228B1

公开(公告)日：2003-02-18

申请号：US09825563

申请日：2001-04-02

Applicant: Steven R. Wiley ,  Raymond G. Goodwin

Inventor： Steven R. Wiley ,  Raymond G. Goodwin

IPC: A61K39395

CPC classification number: C07K14/70575 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/74

Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。

公开(公告)号：US06284236B1

公开(公告)日：2001-09-04

申请号：US09320424

申请日：1999-05-26

Applicant: Steven R. Wiley ,  Raymond G. Goodwin

Inventor： Steven R. Wiley ,  Raymond G. Goodwin

IPC: A61K3819

CPC classification number: C07K14/70575 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/74

Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。