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公开(公告)号：US20100323399A1
公开(公告)日：2010-12-23
申请号：US12779662
申请日：2010-05-13
Applicant: Steven R. Wiley , Raymond G. Goodwin
Inventor： Steven R. Wiley , Raymond G. Goodwin
CPC classification number: C07K14/70575 , C07K16/24 , C07K16/2875 , C07K2317/34 , C07K2317/74
Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。
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公开(公告)号：US07736637B2
公开(公告)日：2010-06-15
申请号：US12195564
申请日：2008-08-21
Applicant: Steven R. Wiley , Raymond G. Goodwin
Inventor： Steven R. Wiley , Raymond G. Goodwin
IPC: A61K38/19
CPC classification number: C07K14/70575 , C07K16/24 , C07K16/2875 , C07K2317/34 , C07K2317/74
Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。
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3.发明授权Compositions and methods relating to multimeric and oligomeric soluble fragments of the TWEAK receptor 失效与TWEAK受体的多聚和低聚可溶性片段相关的组合物和方法公开(公告)号：US07482430B2
公开(公告)日：2009-01-27
申请号：US10898575
申请日：2004-07-23
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
CPC classification number: C07K14/70578 , C07K2319/30 , C07K2319/70 , C07K2319/73
Abstract: The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.
Abstract translation: 本发明提供了涉及包含多聚可溶性TWEAK受体片段和寡聚化结构域的融合蛋白质的方法和组合物。 这种融合蛋白可用于拮抗TWEAK受体和用于治疗由血管生成介导的疾病或病症，例如实体瘤和炎性病症。
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公开(公告)号：US07132264B2
公开(公告)日：2006-11-07
申请号：US11219282
申请日：2005-09-02
Applicant: Howard R. G. Clarke , Robert F. DuBose , Steven R. Wiley
Inventor： Howard R. G. Clarke , Robert F. DuBose , Steven R. Wiley
CPC classification number: C07K14/8121 , A61K38/00 , C07K2317/24 , G01N2333/8121
Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
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公开(公告)号：US5763223A
公开(公告)日：1998-06-09
申请号：US670354
申请日：1996-06-25
Applicant: Steven R. Wiley , Raymond G. Goodwin
Inventor： Steven R. Wiley , Raymond G. Goodwin
IPC: C12N15/09 , A61K38/00 , A61K38/19 , C07K20060101 , C07K14/52 , C07K14/705 , C07K16/24 , C07K16/28 , C12N15/17 , C12N15/19 , C12N15/63 , C12P21/02 , C12P21/08 , C07K14/525
CPC classification number: C07K7/08 , C07K14/70575 , C07K16/2875 , C07K7/06 , A61K38/00 , C07K2317/34 , C07K2319/00
Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
Abstract translation: 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。
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Patent Agency Ranking
公开(公告)号：US07829675B2
公开(公告)日：2010-11-09
申请号：US12355733
申请日：2009-01-16
Applicant: Kristine M. Kim , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
Inventor： Kristine M. Kim , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
IPC: C07K16/00
CPC classification number: A61K39/3955 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US20100183548A1
公开(公告)日：2010-07-22
申请号：US12751912
申请日：2010-03-31
Applicant: STEVEN R. WILEY
Inventor： STEVEN R. WILEY
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US07732588B2
公开(公告)日：2010-06-08
申请号：US12355729
申请日：2009-01-16
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。
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公开(公告)号：US20090137036A1
公开(公告)日：2009-05-28
申请号：US12355733
申请日：2009-01-16
Applicant: KRISTINE M. KIM , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
Inventor： KRISTINE M. KIM , Steven R. Wiley , Randal R. Ketchem , William C. Fanslow, III
CPC classification number: A61K39/3955 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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公开(公告)号：US07517962B2
公开(公告)日：2009-04-14
申请号：US10862109
申请日：2004-06-04
Applicant: Steven R. Wiley
Inventor： Steven R. Wiley
IPC: C07K16/00 , C12N5/12 , A61K39/395
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/73
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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