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    ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS
    34.
    发明申请
    ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS 审中-公开

    公开(公告)号：US20200095308A1

    公开(公告)日：2020-03-26

    申请号：US16705538

    申请日：2019-12-06

    Applicant: Thomas Jefferson University

    Inventor： Andrzej Fertala ,  Andrzej Steplewski

    IPC: C07K16/18

    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the α2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

    MEASURING FREQUENCY OF VARIOUS SUBSETS OF PATHOGEN-SPECIFIC T CELLS IN PERIPHERAL BLOOD AS ESTABLISHED BY VARIOUS PATTERNS OF TCR-INDUCED CA2+ SIGNALING
    36.
    发明申请
    MEASURING FREQUENCY OF VARIOUS SUBSETS OF PATHOGEN-SPECIFIC T CELLS IN PERIPHERAL BLOOD AS ESTABLISHED BY VARIOUS PATTERNS OF TCR-INDUCED CA2+ SIGNALING 审中-公开

    公开(公告)号：US20200064338A1

    公开(公告)日：2020-02-27

    申请号：US16612675

    申请日：2018-05-14

    Applicant: Thomas Jefferson University

    Inventor： Yuri Sykulev ,  Nadezhda Anikeyeva

    IPC: G01N33/50 ,  G01N33/84

    Abstract: A method for measuring kinetics of Ca2+ flux in differentially responding T cells that form monolayer on the glass surface in response to antigenic peptides or live target cells comprising: immobilizing T cells labeled with Ca2+ sensitive fluorophore on the glass bottom of a well, covered with capturing antibody or a capturing protein that bind to non-stimulatory T-cell surface receptor; adding to the well a single or multiple peptide epitopes that binds to the cell surface MHC molecules to be presented for recognition by cognate T cells; the stimulatory signal could also be delivered by live target cells that display peptide epitope(s); wherein the recognition of stimulatory of pMHC by the peptide specific T cells leads to increase of intracellular Ca2+ level and fluorescence intensity in the responding T cells.

    METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE
    40.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE 审中-公开

    公开(公告)号：US20190365794A1

    公开(公告)日：2019-12-05

    申请号：US16518253

    申请日：2019-07-22

    Applicant: Thomas Jefferson University

    Inventor： David W. Andrews ,  Douglas C. Hooper

    IPC: A61K31/7105 ,  A61K39/00 ,  A61P35/00 ,  A61K31/713 ,  C12N15/113

    Abstract: The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.

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