公开(公告)号：US20140088008A1

公开(公告)日：2014-03-27

申请号：US14085056

申请日：2013-11-20

Applicant: Amgen Inc.

Inventor： Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

IPC: C07K14/71

CPC classification number: C07K14/71 ,  C07K2319/30

Abstract: The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

Abstract translation: 本发明提供能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的新型激活素IIB5受体多肽。 本发明还提供能够产生受体多肽的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦，代谢和其它疾病的组合物和方法。