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    AEROSOL DELIVERY SYSTEM AND USES THEREOF
    31.
    发明申请
    AEROSOL DELIVERY SYSTEM AND USES THEREOF 审中-公开
    航空运输系统及其用途

    公开(公告)号：US20080038363A1

    公开(公告)日：2008-02-14

    申请号：US11687466

    申请日：2007-03-16

    申请人： Alejandro Zaffaroni ,  Joshua Rabinowitz

    发明人： Alejandro Zaffaroni ,  Joshua Rabinowitz

    IPC分类号： A61K9/14 ,  A61K31/5513 ,  A61P25/00 ,  A61K31/5517

    CPC分类号： A61M11/041 ,  A61M11/001 ,  A61M11/005 ,  A61M11/042 ,  A61M11/048 ,  A61M15/002

    摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

    摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向基板供应热量以产生大于300℃的基板温度，并且在2秒或更短的时间段内基本上使药物组合物膜从基板挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

    Drug and excipient aerosol compositions
    32.
    发明申请
    Drug and excipient aerosol compositions 审中-公开
    药物和赋形剂气溶胶组合物

    公开(公告)号：US20070286816A1

    公开(公告)日：2007-12-13

    申请号：US11744799

    申请日：2007-05-04

    申请人： Ron Hale ,  Joshua Rabinowitz ,  Daniel Myers ,  Amy Lu ,  Alejandro Zaffaroni

    发明人： Ron Hale ,  Joshua Rabinowitz ,  Daniel Myers ,  Amy Lu ,  Alejandro Zaffaroni

    IPC分类号： A61K9/12

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。

    Delivery of diazepam through an inhalation route
    33.
    发明申请
    Delivery of diazepam through an inhalation route 失效
    通过吸入路线递送地西泮

    公开(公告)号：US20060269486A1

    公开(公告)日：2006-11-30

    申请号：US11500736

    申请日：2006-08-07

    申请人： Joshua Rabinowitz ,  Alejandro Zaffaroni

    发明人： Joshua Rabinowitz ,  Alejandro Zaffaroni

    IPC分类号： A61K9/14 ,  A61L9/04

    CPC分类号： A61K9/0073 ,  A61K9/007 ,  A61K31/5513 ,  Y10S514/958

    摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing diazepam that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of diazepam on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol.

    摘要翻译： 本发明涉及通过吸入途径递送用于治疗焦虑症和这种病症症状的化合物。 具体来说，它涉及用于吸入治疗的含有地西泮的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用地西泮。 该方法包括：a）在固体支持物上加热薄层的地西泮以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径递送地西泮的试剂盒，其包括：a）地西泮组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。

    Nonabsorbable antioxidant method
    36.
    发明授权
    Nonabsorbable antioxidant method 失效
    不可吸收的抗氧化方法

    公开(公告)号：US4104196A

    公开(公告)日：1978-08-01

    申请号：US666845

    申请日：1976-03-15

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A23L29/00 ,  A23L2/44 ,  A23L3/34 ,  A23L3/3463 ,  A23L3/349 ,  A23L27/60 ,  C08K9/00 ,  C11B5/00 ,  C09K15/08

    CPC分类号： A23L3/3463 ,  C08K9/00

    摘要： Novel, nonabsorbable antioxidants of the general formula (An).sub.n R wherein An is a means for preventing oxidation of an oxidizable material, R is a means for essentially restricting the absorption of An in a biological environment, .about. is a means for covalently bonding An to R for a prolonged time, and n is at least one. The nonabsorbable antioxidants are useful as stabilizers in oxidizable materials without any substantial absorption of the antioxidant in the biological environment.

    摘要翻译： 新型的通式（An）nR的不可吸收的抗氧化剂，其中An是用于防止可氧化材料的氧化的手段，R是用于基本上限制An在生物环境中的吸收的手段，DIFFERENCE是用于共价键合An至 R长时间，n至少为1。 不可吸收的抗氧化剂可用作可氧化材料中的稳定剂，而在生物环境中没有任何明显的抗氧化剂吸收。

    Nonabsorbable antioxidant
    37.
    发明授权
    Nonabsorbable antioxidant 失效
    不可吸收的抗氧化剂

    公开(公告)号：US3994828A

    公开(公告)日：1976-11-30

    申请号：US367971

    申请日：1973-06-07

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A23L29/00 ,  A23L2/44 ,  A23L3/34 ,  A23L3/3463 ,  A23L3/349 ,  A23L27/60 ,  C08K9/00 ,  C11B5/00 ,  C09K15/08

    CPC分类号： A23L3/3463 ,  C08K9/00

    摘要： Novel, nonabsorbable antioxidants of the general formula (An).sub.n R wherein An is a means for preventing oxidation of an oxidizable material, R is a means for essentially restricting the absorption of An in a biological environment, .about. is a means for covalently bonding An to R for a prolonged time, and n is at least one. The nonabsorbable antioxidants are useful as stabilizers in oxidizable materials without any substantial absorption of the antioxidant in the biological environment.

    摘要翻译： 通式（An）n R的新型非吸收性抗氧化剂其中An是防止可氧化材料氧化的手段，R是用于基本上限制An在生物环境中的吸收的手段，差异是共价键合的手段 到R长时间，n是至少一个。 不可吸收的抗氧化剂可用作可氧化材料中的稳定剂，而在生物环境中没有任何明显的抗氧化剂吸收。

    Novel drug delivery device
    38.
    发明授权
    Novel drug delivery device 失效
    新型药物输送装置

    公开(公告)号：US3993073A

    公开(公告)日：1976-11-23

    申请号：US554731

    申请日：1975-03-03

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/70 ,  A61L15/58 ,  A61M31/00 ,  A61F5/46 ,  A61F7/02

    CPC分类号： A61K9/0092 ,  A61F6/144 ,  A61K9/0024 ,  A61K9/0036 ,  A61K9/0039 ,  A61L15/58 ,  A61M31/002

    摘要： A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the passage of the drug and in which the drug has limited solubility. The wall is formed in at least a part of a drug release rate controlling material also permeable to the passage of the drug, but the rate of passage of the drug through the wall is lower than the rate passage of the drug through the drug carrier so that drug release by the wall is the drug release rate controlling step for releasing drug from the drug delivery device.

    摘要翻译： 用于以受控的速率长时间施用药物以产生局部或全身的生理或药理作用的药物递送装置由围绕包含药物的储器的壁组成。 储存器由药物载体形成，药物载体可通过药物通过，药物具有有限的溶解度。 该壁形成在药物释放速率控制材料的至少一部分上，其也可以通过药物的通过，但药物通过壁的速度低于药物通过药物载体的速率， 药物释放速率控制步骤是从药物释放装置释放药物。

    Microporous drug delivery device
    39.
    发明授权
    Microporous drug delivery device 失效
    微孔药物输送装置

    公开(公告)号：US3993072A

    公开(公告)日：1976-11-23

    申请号：US623427

    申请日：1975-10-17

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A61F6/14 ,  A61M31/00 ,  A61F5/46 ,  A61F13/20

    CPC分类号： A61F6/14 ,  A61M31/002

    摘要： A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to the passage of the drug. The wall is formed in at least a part of a microporous material the pores of which contain a drug release rate controlling medium also permeable to the passage of the drug, but the rate of passage of the drug through the medium is lower than the rate passage of the drug through the solid drug carrier so that drug release by the medium in the microporous wall is the drug release rate controlling step for releasing drug from the drug delivery device.

    摘要翻译： 用于以受控的速率长时间施用药物以产生局部或全身的生理或药理作用的药物递送装置由围绕包含药物的储器的壁组成。 储存器由可通过药物通过的固体药物载体形成。 该壁形成在微孔材料的至少一部分中，微孔材料的孔含有药物释放速率控制介质，其也可以通过药物通过，但药物通过培养基的速率低于速率通道 的药物通过固体药物载体使得通过介质在微孔壁中的药物释放是用于从药物递送装置释放药物的药物释放速率控制步骤。

    Drug delivery device
    40.
    发明授权
    Drug delivery device 失效
    给药装置

    公开(公告)号：US3967618A

    公开(公告)日：1976-07-06

    申请号：US555840

    申请日：1975-03-06

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/70 ,  A61L15/58 ,  A61M31/00 ,  A61F5/46

    CPC分类号： A61K9/0092 ,  A61F6/144 ,  A61F9/0017 ,  A61K9/0024 ,  A61K9/0036 ,  A61K9/0039 ,  A61L15/58 ,  A61M31/002

    摘要： A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the passage of the drug and in which the drug has limited solubility. The wall is formed in at least a part of a drug release rate controlling material also permeable to the passage of the drug, but the rate of passage of the drug through the wall is lower than the rate passage of the drug through the drug carrier so that drug release by the wall is the drug release rate controlling step for releasing drug from the drug delivery device.

    摘要翻译： 用于以受控的速率长时间施用药物以产生局部或全身的生理或药理作用的药物递送装置由围绕包含药物的储器的壁组成。 储存器由药物载体形成，药物载体可通过药物通过，药物具有有限的溶解度。 该壁形成在药物释放速率控制材料的至少一部分上，其也可以通过药物的通过，但药物通过壁的速度低于药物通过药物载体的速率， 药物释放速率控制步骤是从药物释放装置释放药物。