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公开(公告)号：US20060269487A1
公开(公告)日：2006-11-30
申请号：US11501246
申请日：2006-08-07
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of an NSAID, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particle having less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a coating of an NSAID composition and b) a device for dispensing said coating as a condensation aerosol.
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公开(公告)号：US20060239936A1
公开(公告)日：2006-10-26
申请号：US11454573
申请日：2006-06-16
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing lidocaine, verapamil, diltiazem, isometheptene, or lisuride that are used in inhalation therapy. In a method aspect of the present invention, lidocaine, verapamil, diltiazem, isometheptene, or lisuride is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of lidocaine, verapamil, diltiazem, isometheptene, or lisuride, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering lidocaine, verapamil, diltiazem, isometheptene, or lisuride through an inhalation route is provided which comprises: a) a thin coating of a lidocaine, verapamil, diltiazem, isometheptene, or lisuride composition and b) a device for dispensing said thin coating as a condensation aerosol.
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3.发明申请Delivery of compounds for the treatment of parkinson's through an inhalation route 有权通过吸入路线输送治疗帕金森氏症的化合物公开(公告)号：US20060216244A1
公开(公告)日：2006-09-28
申请号：US11442917
申请日：2006-05-30
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antiparkinsons drugs through an inhalation route. In a method aspect of the present invention, an antiparkinsons drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiparkinsons drug on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering an antiparkinsons drug through an inhalation route is provided which comprises: a) a thin coating of a an antiparkinsons drug composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送抗帕金森药物。 在本发明的方法方面，通过吸入途径向患者施用抗帕金森药物。 该方法包括：a）在固体支持物上加热抗反注射药物的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送反注射药物的试剂盒，其包括：a）抗反注射药物组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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公开(公告)号：US20050075273A1
公开(公告)日：2005-04-07
申请号：US10749539
申请日：2003-12-30
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4418 , A61K31/4525 , A61K31/4545 , A61K31/46 , A61K31/473 , A61K31/48 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/505 , A61K31/519 , A61K31/53 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K45/00 , A61K47/48 , A61M11/00 , A61P15/10 , A61P21/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07D471/04 , C07D487/04 , F24V30/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin coating of an opioid composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送阿片样物质。 具体地说，它涉及用于吸入治疗的含有阿片样物质的气溶胶。 在本发明的方法方面，通过吸入途径将阿片样物质递送至患者。 该方法包括：a）加热组合物，其中组合物包含阿片样物质以形成蒸气; 和b）允许蒸气冷却，从而形成包含具有小于5％的阿片样降解产物的颗粒的冷凝气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送阿片样物质的试剂盒，其包括：a）阿片剂组合物的薄涂层和b）用于将所述薄涂层分配为凝结气溶胶的装置。
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公开(公告)号：US20070178052A1
公开(公告)日：2007-08-02
申请号：US11621397
申请日：2007-01-09
IPC分类号： A61K31/485 , A61K9/14
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an opioid, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin layer of an opioid and b) a device for dispensing said thin layer as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送阿片样物质。 具体地说，它涉及用于吸入治疗的含有阿片样物质的气溶胶。 在本发明的方法方面，通过吸入途径将阿片样物质递送至患者。 该方法包括：a）在固体支持物上加热阿片样物质的薄层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％阿片样降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送阿片样物质的试剂盒，其包括：a）阿片样物质的薄层，以及b）用于将所述薄层分配为冷凝气溶胶的装置。
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公开(公告)号：US20070014737A1
公开(公告)日：2007-01-18
申请号：US11523685
申请日：2006-09-19
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing muscle relaxants that are used in inhalation therapy. In a method aspect of the present invention, a muscle relaxant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a muscle relaxant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% muscle relaxant degradation products. In a kit aspect of the present invention, a kit for delivering a muscle relaxant through an inhalation route is provided which comprises: a) a coating of a muscle relaxant and b) a device for dispensing said coating a muscle relaxant as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送肌肉松弛剂。 具体地说，它涉及用于吸入治疗的含有肌肉松弛剂的气溶胶。 在本发明的方法方面，肌肉松弛剂通过吸入途径输送给患者。 该方法包括：a）在固体支持物上加热肌肉松弛剂的涂层以形成蒸汽; 并且b）使空气通过加热的蒸气以产生具有小于5％肌肉松弛剂降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送肌肉松弛剂的试剂盒，其包括：a）肌肉松弛剂的涂层，和b）用于将所述涂层分配为肌肉松弛剂作为凝结气溶胶的装置。
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公开(公告)号：US20060280692A1
公开(公告)日：2006-12-14
申请号：US11488932
申请日：2006-07-18
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
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公开(公告)号：US20060216243A1
公开(公告)日：2006-09-28
申请号：US11439475
申请日：2006-05-24
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to aerosols containing of atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, of atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of atenolol, pindolol, esmolol, propranolol, or metoprolol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及含有用于吸入治疗的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔。 该方法包括：a）在固体支持物上加热阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径递送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的试剂盒，其包括：a）将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔 组合物和b）用于将所述薄涂层分配为冷凝气溶胶的装置。
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公开(公告)号：US20060153779A1
公开(公告)日：2006-07-13
申请号：US11370628
申请日：2006-03-07
IPC分类号： A61K31/137 , A61K9/14 , A61L9/04
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a stimulant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% stimulant degradation products. In a kit aspect of the present invention, a kit for delivering a stimulant through an inhalation route is provided which comprises: a) a coating of a stimulant drug and b) a device for dispensing said coating a stimulant as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送兴奋剂。 具体地说，它涉及用于吸入治疗的含有兴奋剂的气溶胶。 在本发明的方法方面，兴奋剂通过吸入途径输送给患者。 该方法包括：a）在固体支持物上加热兴奋剂的涂层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％刺激性降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送兴奋剂的试剂盒，其包括：a）刺激性药物的涂层和b）用于将所述涂层分配为兴奋剂作为凝结气溶胶的装置。
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公开(公告)号：US20080038363A1
公开(公告)日：2008-02-14
申请号：US11687466
申请日：2007-03-16
IPC分类号： A61K9/14 , A61K31/5513 , A61P25/00 , A61K31/5517
CPC分类号： A61M11/041 , A61M11/001 , A61M11/005 , A61M11/042 , A61M11/048 , A61M15/002
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向基板供应热量以产生大于300℃的基板温度，并且在2秒或更短的时间段内基本上使药物组合物膜从基板挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。
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