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54 条记录 (耗时 0.063 秒)

    Quinazoline derivatives as tyrosine kinase inhibitors
    32.
    发明授权
    Quinazoline derivatives as tyrosine kinase inhibitors 有权
    喹唑啉衍生物作为酪氨酸激酶抑制剂

    公开(公告)号：US07569577B2

    公开(公告)日：2009-08-04

    申请号：US10573090

    申请日：2004-09-13

    申请人： Laurent Francois Andre Hennequin ,  Christopher Thomas Halsall

    发明人： Laurent Francois Andre Hennequin ,  Christopher Thomas Halsall

    IPC分类号： A61K31/517 ,  C07D239/94

    CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： The invention concerns quinazoline derivatives of the Formula (I); wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物; 其中R1，R2，W，X1，X2，Z，a和b各自如说明书中所定义; 其准备过程; 含有它们的药物组合物及其在制备用于提供抗增殖作用的药物中的用途。 预期式（I）的喹唑啉衍生物可用于治疗诸如由erbB受体酪氨酸激酶，特别是EGFR酪氨酸激酶介导的某些癌症的疾病。

    Quinoline derivatives having VEGF inhibiting activity
    33.
    发明授权
    Quinoline derivatives having VEGF inhibiting activity 失效
    具有VEGF抑制活性的喹啉衍生物

    公开(公告)号：US07371765B2

    公开(公告)日：2008-05-13

    申请号：US10332274

    申请日：2001-08-08

    申请人： Laurent Francois Andre Hennequin

    发明人： Laurent Francois Andre Hennequin

    IPC分类号： A61K31/47 ,  A61K31/54 ,  A61K31/497 ,  A01N43/42 ,  C07D215/00 ,  C07D215/38 ,  C07D279/10 ,  C07D279/12 ,  C07D401/00 ,  C07D295/00

    CPC分类号： C07D401/12 ,  C07D401/14

    摘要： The invention relates to compounds of formula (I) wherein: either any one of G1, G2, G3, G4 and G5 is nitrogen and the other four are —CH—, or G1, G2, G3, G4 and G5 are all —CH—; Z is —O—, —NH—, —S—, —CH2— or a direct bond; Z is linked to any one of G1, G2, G3 and G4; n is an integer from 0 to 5; m is an integer from 0 to 3; Ra represents hydrogen or fluoro; Rb, R1 and R2 are defined herein and salt thereof, process for the preparation so such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and the use of a compound of formula I in the manufacture of a medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of diseases states including cancer and rheumatoid arthritis.

    摘要翻译： 本发明涉及式（I）的化合物，其中：G 1，G 2，G 3，G 3， 4和G 5是氮，而另外四个是-CH-或G 1，G 2，G

    4-anilino quinazoline derivatives as antiproliferative agents
    35.
    发明授权
    4-anilino quinazoline derivatives as antiproliferative agents 失效
    4-苯胺基喹唑啉衍生物作为抗增殖剂

    公开(公告)号：US08399667B2

    公开(公告)日：2013-03-19

    申请号：US12706675

    申请日：2010-02-16

    申请人： Robert Hugh Bradbury ,  Laurent Francois Andre Hennequin ,  Jason Grant Kettle

    发明人： Robert Hugh Bradbury ,  Laurent Francois Andre Hennequin ,  Jason Grant Kettle

    IPC分类号： C07D239/72

    CPC分类号： C07D401/12 ,  C07D403/12

    摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q1，Z，R1和Q2各自具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。

    Quinazoline derivatives and their use in the treatment of cancer
    36.
    发明授权
    Quinazoline derivatives and their use in the treatment of cancer 失效
    喹唑啉衍生物及其在治疗癌症中的应用

    公开(公告)号：US07659279B2

    公开(公告)日：2010-02-09

    申请号：US10555085

    申请日：2004-04-27

    申请人： Laurent Francois Andre Hennequin ,  Alleyn Plowright

    发明人： Laurent Francois Andre Hennequin ,  Alleyn Plowright

    IPC分类号： A61K31/517 ,  C07D239/88

    CPC分类号： C07D403/12 ,  C07D403/14

    摘要： The invention concerns quinazoline derivatives of the formula: (I); wherein X1, Q1, Z, R1, R2, Y, a and m are as defined in the description, which are erbB tyrosine kinase inhibitors, particularly EGFR tyrosine kinase inhibitors. Also claimed are processes for their preparation; pharmaceutical compositions containing them; and their use as therapeutic agents in the treatment of erbB tyrosine kinase mediated diseases such as cancer.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物： 其中X1，Q1，Z，R1，R2，Y，a和m如描述中所定义，其是erbB酪氨酸激酶抑制剂，特别是EGFR酪氨酸激酶抑制剂。 还要求他们的准备过程; 含有它们的药物组合物; 以及它们在治疗erbB酪氨酸激酶介导的疾病如癌症中的用途。

    4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS
    40.
    发明申请
    4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS 审中-公开
    4-苯胺喹诺酮衍生物作为抗增生剂

    公开(公告)号：US20080269487A1

    公开(公告)日：2008-10-30

    申请号：US12147250

    申请日：2008-06-26

    申请人： Robert Hugh Bradbury ,  Laurent Francois Andre Hennequin ,  Jason Grant Kettle

    发明人： Robert Hugh Bradbury ,  Laurent Francois Andre Hennequin ,  Jason Grant Kettle

    IPC分类号： C07D401/02

    CPC分类号： C07D401/12 ,  C07D403/12

    摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q 1，Z，R 1和Q 2 2中的每一个具有定义的任何含义 在说明中; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。