公开(公告)号：US20240076266A1

公开(公告)日：2024-03-07

申请号：US18451579

申请日：2023-08-17

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Yen-Hao Hsu ,  Tatyana Dyndikova

IPC: C07C273/18

CPC classification number: C07C273/1872

Abstract: In various aspects, the present disclosure pertains to systems for forming hydrogels that comprise an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems. Still other aspects of the present disclosure pertain to methods of making iodinated polyamino compounds.

公开(公告)号：US20230241295A1

公开(公告)日：2023-08-03

申请号：US18103932

申请日：2023-01-31

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Yen-Hao Hsu ,  Tatyana Dyndikova

IPC: A61L31/14 ,  A61L31/04 ,  A61M5/19 ,  C07C233/66

CPC classification number: A61L31/145 ,  A61L31/041 ,  A61M5/19 ,  C07C233/66

Abstract: In some aspects, the present disclosure pertains to systems for forming hydrogels that comprise (a) a first composition that comprises a polyiodinated polyamino compound that comprises a polyamino moiety linked to a polyiodinated aromatic moiety by an amide group or ester group and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the polyiodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels and methods of making medical hydrogels that are based on such compositions. Further aspects of the present disclosure pertain to methods of making polyiodinated polyamino compounds.