公开(公告)号：US20240341633A1

公开(公告)日：2024-10-17

申请号：US18642331

申请日：2024-04-22

申请人： Senseonics, Incorporated

发明人： Joon Chatterjee ,  Venkata Velvadapu ,  Mark Mortellaro ,  Philip Huffstetler

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08F283/06 ,  C08K5/55 ,  G01N21/75 ,  G01N21/77 ,  G01N33/50

CPC分类号： A61B5/14503 ,  A61B5/14546 ,  A61L31/041 ,  A61L31/145 ,  A61L31/16 ,  C08F283/06 ,  C08K5/55 ,  G01N21/75 ,  G01N21/77 ,  G01N33/50 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/14865

摘要： A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having metal chelating moieties that reduce degradation of the analyte indicator.

公开(公告)号：US20240315250A1

公开(公告)日：2024-09-26

申请号：US18734194

申请日：2024-06-05

申请人： Nevada Naturals Inc.

发明人： Anthony J. Sawyer ,  Richard F. Stockel

IPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/00 ,  A61L26/00 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/005 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A01N2300/00 ,  A61L26/0066 ,  A61L2300/406 ,  A61L2400/04

摘要： Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

公开(公告)号：US20240263002A1

公开(公告)日：2024-08-08

申请号：US18431202

申请日：2024-02-02

申请人： The University of Hong Kong

发明人： Lizhi XU ,  Huimin HE ,  Hao LI

IPC分类号： C08L29/04 ,  A61B5/251 ,  A61B5/268 ,  A61B5/28 ,  A61B5/296 ,  A61L31/04 ,  A61L31/14 ,  C08J3/075 ,  F24S70/14

CPC分类号： C08L29/04 ,  A61B5/251 ,  A61B5/268 ,  A61B5/28 ,  A61B5/296 ,  A61L31/041 ,  A61L31/145 ,  C08J3/075 ,  F24S70/14 ,  A61B2562/0209 ,  A61L2400/12 ,  C08J2329/04 ,  C08J2439/04 ,  C08J2477/00 ,  C08L2203/02 ,  C08L2205/03 ,  C08L2205/16

摘要： An electroconductive hydrogel is formed by hybrid assembly of polymeric nanofiber networks of conducting polymers that self-organize into highly connected 3D nanostructures with an ultralow threshold (˜1 wt %) for electrical percolation. A method for forming the electroconductive hydrogel comprises the steps of: dispersing aramid nanofibers (ANFs) in dimethyl sulfoxide (DMSO); conducting a solvent exchange with water to generate hydrogels with connective 3D fibrillar networks that serve as templates for the assembly of conducting polymers; incorporating polyvinyl alcohol (PVA) during the processing of the hydrogels to weld the fibrillar joints via hydrogen bonding; infiltrating monomers into the nano-porous hydrogels in an aqueous media; and polymerizing the hydrogels with added oxidants.

公开(公告)号：US20240139382A1

公开(公告)日：2024-05-02

申请号：US18278738

申请日：2022-02-04

申请人： TORAY INDUSTRIES, INC.

发明人： Rumiko KITAGAWA ,  Masataka NAKAMURA

IPC分类号： A61L29/08 ,  A61L26/00 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L29/085 ,  A61L26/008 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61L2300/424 ,  A61L2400/10 ,  A61L2420/02

摘要： An object of the present invention is to provide a coated medical device allowed to have not only sufficient hydrophilicity and lubricity but also a lipid adhesion inhibiting capability, and to provide a simple method for manufacturing the device. The present invention provides a coated medical device and a method for manufacturing the same, the coated medical device including a medical device and a hydrophilic polymer layer coating the surface of the medical device; wherein the hydrophilic polymer layer contains a hydrophilic polymer A, the hydrophilic polymer A containing, as monomer units, a compound a1 having a specific structure and a compound a2 having an amide group; and wherein the copolymerization ratio of the compound a1 to the compound a2 is 1/99 to 99/1 by mass.

公开(公告)号：US20240091033A1

公开(公告)日：2024-03-21

申请号：US18524495

申请日：2023-11-30

申请人： Scott M. Epstein

发明人： Scott M. Epstein

IPC分类号： A61F2/844 ,  A61F2/82 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  A61M25/00

CPC分类号： A61F2/844 ,  A61F2/82 ,  A61L29/041 ,  A61L29/145 ,  A61L31/048 ,  A61L31/145 ,  A61M25/0017 ,  A61M2207/00

摘要： The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. One or more physical post-implantation dimensions of the device can be controlled by placing it in a solution that has a predetermined osmolarity and/or pH. In addition, the device can deliver an absorbed therapeutic agent to a target anatomical site. Alternatively, the device can function as a selective membrane to selectively absorb one or more target molecules from a body fluid.

公开(公告)号：US20240041643A1

公开(公告)日：2024-02-08

申请号：US18480910

申请日：2023-10-04

申请人： Alan N. Schwartz

发明人： Alan N. Schwartz

IPC分类号： A61F6/20 ,  A61F5/00 ,  A61F5/453 ,  A61F13/00 ,  A61F13/04 ,  A61F13/10 ,  A61F13/20 ,  A61L28/00 ,  A61L31/14 ,  A61F5/451

CPC分类号： A61F6/20 ,  A61F5/00 ,  A61F5/453 ,  A61F13/00008 ,  A61F13/00034 ,  A61F13/00063 ,  A61F13/041 ,  A61F13/10 ,  A61F13/2005 ,  A61F13/2017 ,  A61L28/0049 ,  A61L31/145 ,  A61F5/451 ,  Y10T428/24008 ,  Y10T428/24802 ,  Y10T428/31826 ,  Y10T428/31938 ,  A61F13/00068 ,  A61F13/141

摘要： An apparatus that includes a mask is provided, the mask including one or more fixation anchoring devices, each configured to anchor to an at least one body part within a user, wherein the at least one body part includes at least a portion of one or more of an oral, nasal, pharyngeal, and a respiratory airway; one or more skin covers, each capable of covering at least a portion of the user's face, wherein one or more of the fixation anchoring devices are connected to one or more skin covers; one or more conduits, each connected to at least a portion of one of the skin covers, wherein one or more of a gas, solid, liquid, and gel are transmitted through each of the conduits; and one or more sealing pads, each connected to at least one of one of the skin coverings and one of the fixation anchoring devices.

公开(公告)号：US20230414844A1

公开(公告)日：2023-12-28

申请号：US17899612

申请日：2022-08-31

申请人： Hangzhou Singclean Medical Products Co., Ltd

发明人： Zhihong Zhang ,  Qingzhi Deng ,  Yufei Xiong ,  Wei Huang

IPC分类号： A61L31/14 ,  A61L31/04

CPC分类号： A61L31/145 ,  A61L31/042 ,  A61L31/048

摘要： The present disclosure discloses a cross-linked hydrogel microneedle for transdermal drug delivery and a method for preparing the same. The preparation method includes the following steps: mixing a polyvinyl alcohol solution and a hyaluronic acid solution; freeze-thawing the mixed solution in a mold to obtain a gel with no fluidity; and demolding the gel and further performing irradiation cross-linking to obtain the cross-linked hydrogel microneedle. The preparation method described in the present disclosure overcomes the problem of poor stability that exists in the preparation by a freeze-thaw method and the problem of easy introduction of air bubbles that exists in the preparation by an irradiation method, and can increase the yield of the microneedles, which is conducive to mass production. The prepared microneedles can be transported and stored for a long time and have wide application prospects.

公开(公告)号：US20230372582A1

公开(公告)日：2023-11-23

申请号：US18363760

申请日：2023-08-02

申请人： SHANGHAI LINGEL MEDICAL TECHNOLOGY CO., LTD.

发明人： Yiqing ZHANG ,  Yu SUN

IPC分类号： A61L26/00 ,  A61L31/14 ,  A61L24/00 ,  A61L24/04 ,  A61L31/04 ,  C08G65/333 ,  C08G69/50 ,  C08G63/91

CPC分类号： A61L26/008 ,  A61L31/145 ,  A61L24/0031 ,  A61L24/043 ,  A61L26/0052 ,  A61L31/041 ,  C08G65/33396 ,  C08G69/50 ,  C08G63/912 ,  A61L2400/04

摘要： This invention provides the preparation and applications of a degradable dual-component hydrogel. The hydrogel is prepared by mixing component A, component B and solvent; Component A is an o-phthalaldehyde modified degradable polymer; Component B is a water-soluble molecule, a water-soluble synthetic polymer, or a polysaccharide that contains one or more types of the groups selected from primary amine, hydrazine, hydrazide, hydroxylamine and sulfhydryl, with the number of groups not less than 2. This invention achieves the regulation for hydrogel degradability by introducing degradable structures into the polymer skeleton of component A, and obtains hydrogels with rapid degradation. This invention thus solve the dilemma of materials—confronting either the problems of undegradable poly (ethylene glycol) skeleton or the potential risks of the degradable bioproducts introduced—used for preparing the dual-component hydrogel.

公开(公告)号：US20230372576A1

公开(公告)日：2023-11-23

申请号：US18229369

申请日：2023-08-02

申请人： MicroVention, Inc.

发明人： Aaron Baldwin

IPC分类号： A61L24/06 ,  A61L24/00 ,  A61L31/14 ,  A61L31/18

CPC分类号： A61L24/06 ,  A61L24/0031 ,  A61L24/001 ,  A61L31/14 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36

摘要： Described herein are polymers and associated methods to occlude structures and malformations of the vasculature with polymers with delayed controlled rates of expansion. Methods of forming such devices are also disclosed.

公开(公告)号：US20230355846A1

公开(公告)日：2023-11-09

申请号：US18321238

申请日：2023-05-22

申请人： Board Of Regents, The University Of Texas System

发明人： Sarah Mayes ,  Christine E. Schmidt

IPC分类号： A61L31/04 ,  A61L31/14 ,  A61K31/195 ,  A61K31/192 ,  A61L31/16

CPC分类号： A61L31/041 ,  A61K31/192 ,  A61K31/195 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/62

摘要： A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.