-
公开(公告)号：US08759361B2
公开(公告)日：2014-06-24
申请号：US13215195
申请日：2011-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： A61K31/522 , A61P25/04 , A61P17/04 , A61P13/10 , C07D473/04 , C07D495/04 , C07D487/04 , A61K31/519
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US07662830B2
公开(公告)日：2010-02-16
申请号：US11204202
申请日：2005-08-13
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P19/02 , A61K31/53
CPC分类号： C07D405/14 , C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14
摘要： Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptors activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的取代的联芳基哌嗪基 - 吡啶类似物：其中变量如本文所述。 这样的化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人，驯养的伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US07566712B2
公开(公告)日：2009-07-28
申请号：US10893799
申请日：2004-07-16
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Stéphane De Lombaert , Taeyoung Yoon , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Stéphane De Lombaert , Taeyoung Yoon , Xiaozhang Zheng
IPC分类号： C07D401/14 , C07D403/14 , A61K31/53 , A61K31/506 , A61P19/02
CPC分类号： C04B35/632 , A61K31/496 , A61K31/506 , A61K31/53 , A61K31/5377 , C07D251/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的双芳基哌嗪基 - 吡啶类似物：其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US20090069347A1
公开(公告)日：2009-03-12
申请号：US11895286
申请日：2007-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： C07D473/02 , A61K31/522 , A61K31/519 , C07D471/04 , C07D513/04 , A61P29/00 , A61P13/00 , A61P25/14 , A61P5/00
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US20080132509A1
公开(公告)日：2008-06-05
申请号：US11792984
申请日：2005-12-13
IPC分类号： A61K31/53 , A61K31/501 , A61K31/506 , A61K31/444 , C07D403/04
CPC分类号： C07D401/14 , C07D401/10
摘要： Substituted biaryl analogues of Formula (I) are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localizations studies.
摘要翻译： 提供式（I）的取代的联芳基类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这种配体进行受体定位研究的方法。
-
公开(公告)号：US07034034B2
公开(公告)日：2006-04-25
申请号：US10274851
申请日：2002-10-21
IPC分类号： A61K31/4164 , A61K31/4178 , C07D233/64 , C07D401/12
CPC分类号： C07D233/64 , C07D401/12
摘要： Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.049 秒)
