-
公开(公告)号：US20120208829A1
公开(公告)日：2012-08-16
申请号：US13215195
申请日：2011-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： A61K31/522 , C07D471/04 , C07D513/04 , C07D495/04 , A61K31/519 , A61P11/14 , A61P17/04 , A61P11/00 , A61P15/12 , A61P13/00 , A61P13/10 , C07D473/04 , A61P29/00
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US08759361B2
公开(公告)日：2014-06-24
申请号：US13215195
申请日：2011-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： A61K31/522 , A61P25/04 , A61P17/04 , A61P13/10 , C07D473/04 , C07D495/04 , C07D487/04 , A61K31/519
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US20090069347A1
公开(公告)日：2009-03-12
申请号：US11895286
申请日：2007-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： C07D473/02 , A61K31/522 , A61K31/519 , C07D471/04 , C07D513/04 , A61P29/00 , A61P13/00 , A61P25/14 , A61P5/00
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US08003656B2
公开(公告)日：2011-08-23
申请号：US11895286
申请日：2007-08-22
申请人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
发明人： Rajagopal Bakthavatchalam , Scott M. Capitosti , Jianjun Xu , Bertrand L. Chenard , Manuka Ghosh , Charles A. Blum
IPC分类号： C07D473/04 , A61K31/522 , C07D495/04 , C07D487/04 , A61K31/519 , A61P25/04
CPC分类号： C07D473/30 , C07D471/04 , C07D513/04
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供2-苯氧基嘧啶酮类似物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US20090286767A1
公开(公告)日：2009-11-19
申请号：US12368302
申请日：2009-02-09
申请人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Stéphane De Lombaert , Kevin J. Hodgetts
发明人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Stéphane De Lombaert , Kevin J. Hodgetts
IPC分类号： A61K31/397 , C12N5/00 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4375 , A61K31/4709 , C07D413/14 , C07D405/14 , C07D401/14 , C07D401/10 , A61P3/04 , A61P29/00
CPC分类号： C07D401/04 , C07D215/44 , C07D471/04 , C07D491/14
摘要： Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供取代的喹啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US07488740B2
公开(公告)日：2009-02-10
申请号：US10891832
申请日：2004-07-14
申请人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Stéphane De Lombaert , Kevin J. Hodgetts
发明人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Stéphane De Lombaert , Kevin J. Hodgetts
IPC分类号： A61K31/47 , C07D215/38
CPC分类号： C07D401/04 , C07D215/44 , C07D471/04 , C07D491/14
摘要： Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供取代的喹啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US07935702B2
公开(公告)日：2011-05-03
申请号：US11250135
申请日：2005-10-12
申请人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Kevin J. Hodgetts , Scott Michael Capitosti
发明人： Rajagopal Bakthavatchalam , Timothy M. Caldwell , Bertrand L. Chenard , Kevin J. Hodgetts , Scott Michael Capitosti
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC分类号： C07D471/04 , C07D401/04 , C07D401/12 , C07D401/14
摘要： Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供式I的取代的联芳基喹啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US07253168B2
公开(公告)日：2007-08-07
申请号：US11100355
申请日：2005-04-06
申请人： Alan J. Hutchison , Bertrand L. Chenard , James G. Tarrant , Guiying Li , Manuka Ghosh , George P. Luke , John M. Peterson , Wallace C. Pringle , Mary-Margaret E. O'Donnell , Kyungae Lee , Linda M. Gustavson , Dario Doller
发明人： Alan J. Hutchison , Bertrand L. Chenard , James G. Tarrant , Guiying Li , Manuka Ghosh , George P. Luke , John M. Peterson , Wallace C. Pringle , Mary-Margaret E. O'Donnell , Kyungae Lee , Linda M. Gustavson , Dario Doller
IPC分类号： A07D241/36 , A61K31/498 , A61P3/04 , A61P3/10 , C07D239/70 , C07D487/08 , C07D471/14 , A61K31/517 , A61K31/407
CPC分类号： C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译： 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
公开(公告)号：US07662830B2
公开(公告)日：2010-02-16
申请号：US11204202
申请日：2005-08-13
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P19/02 , A61K31/53
CPC分类号： C07D405/14 , C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14
摘要： Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptors activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的取代的联芳基哌嗪基 - 吡啶类似物：其中变量如本文所述。 这样的化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人，驯养的伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
-
公开(公告)号：US20080132509A1
公开(公告)日：2008-06-05
申请号：US11792984
申请日：2005-12-13
IPC分类号： A61K31/53 , A61K31/501 , A61K31/506 , A61K31/444 , C07D403/04
CPC分类号： C07D401/14 , C07D401/10
摘要： Substituted biaryl analogues of Formula (I) are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localizations studies.
摘要翻译： 提供式（I）的取代的联芳基类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这种配体进行受体定位研究的方法。
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.042 秒)
