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31.发明授权Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US08142786B2
公开(公告)日：2012-03-27
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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32.发明申请Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US20110182944A1
公开(公告)日：2011-07-28
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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33.发明授权Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein 有权编码NY-ESO-1蛋白免疫原性部分的分离的核酸分子公开(公告)号：US07888100B2
公开(公告)日：2011-02-15
申请号：US11499547
申请日：2006-08-04
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07H21/04 , C12N5/10 , C12N15/861 , C12N15/70
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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34.发明授权公开(公告)号：US07795379B2
公开(公告)日：2010-09-14
申请号：US11220785
申请日：2005-09-06
申请人： Elke Jager , Dirk Jager , Alexander Knuth
发明人： Elke Jager , Dirk Jager , Alexander Knuth
IPC分类号： C07K5/10
CPC分类号： C07K14/82 , A61K38/1709 , G01N33/5017 , G01N33/57484
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
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35.发明申请Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof 有权编码癌症相关抗原的分离的核酸分子，每个SE的抗原及其用途公开(公告)号：US20090203123A1
公开(公告)日：2009-08-13
申请号：US12011953
申请日：2008-01-30
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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公开(公告)号：US06339140B1
公开(公告)日：2002-01-15
申请号：US09796780
申请日：2001-03-01
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07K100
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途
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37.发明授权Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample 有权通过在患者样品中测定NY-ESO-1的抗体来确定癌症状态的方法公开(公告)号：US06251603B1
公开(公告)日：2001-06-26
申请号：US09359503
申请日：1999-07-23
申请人： Elke Jäger , Elisabeth Stockert , Lloyd J. Old , Alexander Knuth
发明人： Elke Jäger , Elisabeth Stockert , Lloyd J. Old , Alexander Knuth
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18 , G01N33/574
摘要： The invention relates to methods for determining tumor status by determining antibodies specific to NY-ESO-1 in patient samples. One can determine whether a cancerous condition is progressing, regressing, or remaining stable by determining antibodies against NY-ESO-1 in a patient sample, and comparing the value obtained to a prior value. When the tumor in question expresses NY-ESO-1, a change in this value is indicative of a change in status of the cancerous condition.
摘要翻译： 本发明涉及通过测定患者样品中NY-ESO-1特异性的抗体来确定肿瘤状态的方法。 可以通过确定患者样品中针对NY-ESO-1的抗体，并将获得的值与先前值进行比较来确定癌症状况是否进展，回归或保持稳定。 当所讨论的肿瘤表达NY-ESO-1时，该值的变化表示癌症状态的变化。
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