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    Crystalline and amorphous forms of beta-L-2′-deoxythymidine
    32.
    发明授权
    Crystalline and amorphous forms of beta-L-2′-deoxythymidine 有权
    β-L-2'-deoxythymidine的结晶和无定形形式

    公开(公告)号：US07589079B2

    公开(公告)日：2009-09-15

    申请号：US11807232

    申请日：2007-05-25

    申请人： David Jonaitis ,  Richard Storer

    发明人： David Jonaitis ,  Richard Storer

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07H19/073 ,  A61K31/7072 ,  C07H19/06

    摘要： Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, thermal properties, and methods of manufacture. These forms of beta-L-2′-deoxythymidine can be used in the manufacture of other forms of beta-L-2′-deoxythymidine, or in pharmaceutical compositions. Particularly preferred uses are in the treatment of hepatitis B.

    摘要翻译： 公开了可以通过物理外观，纯度水平，红外和拉曼光谱学，X射线粉末衍射图，热性质和制造方法来表征的β-L-2'-脱氧胸苷的物理形式。 这些形式的β-L-2'-脱氧胸苷可用于制造其它形式的β-L-2'-脱氧胸苷，或用于药物组合物中。 特别优选的用途是治疗乙型肝炎。

    Substituted phenylindoles for the treatment of HIV
    36.
    发明授权
    Substituted phenylindoles for the treatment of HIV 有权
    用于治疗HIV的取代的苯基吲哚

    公开(公告)号：US07365090B2

    公开(公告)日：2008-04-29

    申请号：US10637949

    申请日：2003-08-07

    申请人： Marino Artico ,  Paolo LaColla ,  Romano Silvestri ,  Adel Moussa ,  Jean-Pierre Sommadossi ,  Richard Storer

    发明人： Marino Artico ,  Paolo LaColla ,  Romano Silvestri ,  Adel Moussa ,  Jean-Pierre Sommadossi ,  Richard Storer

    IPC分类号： A61K31/405 ,  C07D209/14

    CPC分类号： C07D403/04 ,  C07D209/42 ,  C07D403/12

    摘要： This invention is in the area of phenylindoles that are useful for the treatment of HIV infection, and, in particular, phenylindoles that exhibit significant activity against resistant strains of HIV. The phenylindoles have at least two substituents other than hydrogen on the benzo ring of the indole function, preferably at the 4′ and 5′, 5′ and 6′ or the 5′ and 7′ positions, optionally in combination with disubstitution at positions 3″ and 5″ on the phenyl ring of the compound, and carboxamide containing moieties at position-2 on the indole group of the compound. Methyl is a preferred group for substitution on the phenyl ring. Preferred substituents for the benzo ring of the indole function include but are not limited to chlorine, fluorine, bromine, iodine, CF3, methoxy, CN, and NO2.

    摘要翻译： 本发明在可用于治疗HIV感染的苯基吲哚的区域中，特别是对抗HIV抗性菌株显示出显着活性的苯基吲哚。 苯吲哚在吲哚官能团的苯并环上具有至少两个除氢之外的取代基，优选在4'和5'，5'和6'或5'和7'位置，任选地与3位的取代基组合 “和5”，化合物的吲哚基上的位置-2的含羧酰胺的部分。 甲基是在苯环上取代的优选基团。 吲哚官能团的苯并环的优选取代基包括但不限于氯，氟，溴，碘，CF 3，甲氧基，CN和NO 2。