公开(公告)号：US20190233460A1

公开(公告)日：2019-08-01

申请号：US16251287

申请日：2019-01-18

申请人： UNIVERSITE DE BORDEAUX ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Philippe BARTHELEMY ,  Michael RAMIN ,  Laurent LATXAGUE ,  Ananda APPAVOO ,  Olivier CHASSANDE ,  Camille EHRET

IPC分类号： C07H19/06 ,  C07H19/073 ,  A61K47/26 ,  C12N5/00 ,  C07H1/00 ,  A61K9/06

CPC分类号： C07H19/06 ,  A61K9/06 ,  A61K47/26 ,  C07H1/00 ,  C07H19/073 ,  C12N5/0068 ,  C12N2513/00 ,  C12N2533/20 ,  C12N2539/00

摘要： The invention relates to bola-amphiphilic compounds and their uses for biomedical application.The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.

公开(公告)号：US20180000855A1

公开(公告)日：2018-01-04

申请号：US15411506

申请日：2017-01-20

申请人： Gilead Pharmasset LLC

发明人： Jinfa Du ,  Dhanapalan Nagarathnam ,  Michael Joseph Sofia ,  Peiyuan Wang

IPC分类号： A61K31/7072 ,  C07H19/06 ,  A61K45/06 ,  C07H19/073 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7064 ,  C07H19/04

CPC分类号： A61K31/7072 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  C07D417/14 ,  C07H17/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/20 ,  Y02A50/463

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：US20170327526A1

公开(公告)日：2017-11-16

申请号：US15441561

申请日：2017-02-24

申请人： Gilead Sciences, Inc.

发明人： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/073

CPC分类号： C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  C07H19/073 ,  C07H19/10

摘要： Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20170107244A1

公开(公告)日：2017-04-20

申请号：US15360360

申请日：2016-11-23

申请人： MEDIVIR AB

发明人： Genadiy KALAYANOV ,  Staffan TORSSELL ,  Horst WAHLING

IPC分类号： C07H19/06 ,  C07H23/00

CPC分类号： C07H19/06 ,  A61K31/7072 ,  A61K45/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/11 ,  C07H19/16 ,  C07H19/173 ,  C07H19/20 ,  C07H19/213 ,  C07H23/00

摘要： The invention provides compounds of the formula: wherein B is a nucleobase selected from the groups (a) to (d): and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

公开(公告)号：US09617295B2

公开(公告)日：2017-04-11

申请号：US14830121

申请日：2015-08-19

申请人： Gilead Sciences, Inc.

发明人： Michael O'Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07H19/073 ,  C07H19/10 ,  C07H19/06

CPC分类号： C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  C07H19/073 ,  C07H19/10

摘要： Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20160369336A1

公开(公告)日：2016-12-22

申请号：US15188283

申请日：2016-06-21

申请人： LASERGEN, INC.

发明人： Brian P. STUPI ,  Hong LI ,  Weidong WU ,  Megan N. HERSH ,  David HERTZOG ,  Sidney E. MORRIS ,  Michael L. METZKER

IPC分类号： C12Q1/68 ,  C07H19/14 ,  C07H19/10 ,  B01L3/00

CPC分类号： C12Q1/6869 ,  B01L3/5027 ,  B01L2300/0654 ,  B01L2300/168 ,  C07H19/073 ,  C07H19/10 ,  C07H19/14 ,  C07H19/173 ,  C07H19/20 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2525/117 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The present invention relates generally to 3′-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.

公开(公告)号：US20160348110A1

公开(公告)日：2016-12-01

申请号：US15234868

申请日：2016-08-11

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Muthiah MANOHARAN ,  Kallanthottathil G. RAJEEV ,  Alexander V. KELIN ,  Sudhakar Rao TAKKELLAPATI ,  Shigeo MATSUDA

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C07H19/073 ,  C07H19/10 ,  C07H19/173 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336

摘要： The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

摘要翻译： 本发明的另一方面涉及抑制细胞中基因表达的方法，所述方法包括（a）使本发明的寡核苷酸与细胞接触; 和（b）将来自步骤（a）的细胞维持足以获得靶基因的mRNA降解的时间。

公开(公告)号：US20160326207A1

公开(公告)日：2016-11-10

申请号：US15033422

申请日：2014-10-30

申请人： JAPAN SCIENCE AND TECHNOLOGY AGENCY

发明人： Kenzo Fujimoto ,  Shigetaka Nakamura

IPC分类号： C07H19/06

CPC分类号： C07H19/06 ,  C07H19/04 ,  C07H19/073 ,  C07H21/04

摘要： Provided is a means for preventing the inactivation of a photoresponsive nucleic acid probe by suppressing the formation of a photocrosslink between a photoresponsive base having a photocrosslinkable vinyl structure and a photocrosslinkable thymine (T) or uracil (U) base, by substituting with an R group (R being —CN or —CO—R1, where R1 is a saturated or unsaturated straight-chain or branched cyclic or non-cyclic C1-12 hydrocarbon group) the 5 position of a pyrimidine ring of the thymine (T) or uracil (U) base which is photocrosslinkable with the photoresponsive base having a photocrosslinkable vinyl structure.

摘要翻译： 本发明提供通过抑制光可交联乙烯基结构的光响应性碱与光可交联胸腺嘧啶（T）或尿嘧啶（U）碱之间的光交联的形成，通过用R基取代来防止光响应性核酸探针失活的手段 （R为-CN或-CO-R 1，其中R 1为饱和或不饱和的直链或支链环状或非环状C 1-12烃基）胸腺嘧啶（T）或尿嘧啶 U）碱，其与具有可光致交联的乙烯基结构的光响应性碱可光交联。

公开(公告)号：US20160280735A1

公开(公告)日：2016-09-29

申请号：US15007810

申请日：2016-01-27

申请人： Gilead Pharmasset LLC

发明人： Jinfa Du ,  Michael Joseph Sofia

IPC分类号： C07H19/06 ,  C07H19/14 ,  C07H19/16

CPC分类号： C07H19/06 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/073 ,  C07H19/14 ,  C07H19/16 ,  C07H19/173

摘要： Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2′,4′-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.

摘要翻译： 本发明的实施方案是用于治疗病毒感染的化合物，方法和组合物。 更具体地，本发明的实施方案是用于治疗病毒感染的2'，4'-取代的核苷化合物，例如HIV，HCV和HBV感染。

公开(公告)号：US09453043B2

公开(公告)日：2016-09-27

申请号：US14602749

申请日：2015-01-22

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Alexander V. Kelin ,  Sudhakar Rao Takkellapati ,  Shigeo Matsuda

IPC分类号： C07H21/02 ,  C07H21/04 ,  C07H21/00 ,  C07H19/04 ,  C07H19/10 ,  C07H19/20 ,  C07H19/048 ,  C07H19/167 ,  C07H19/073 ,  C07H19/173

CPC分类号： C12N15/113 ,  C07H19/073 ,  C07H19/10 ,  C07H19/173 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336

摘要： The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.