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公开(公告)号：US20150196394A1
公开(公告)日：2015-07-16
申请号：US14637230
申请日：2015-03-03
Applicant: Edwards Lifesciences Corporation
Inventor： Michael C. Murad , Emil Karapetian , Wesley V. Adzich
IPC: A61F2/24
CPC classification number: A61F2/2427 , A61F2/0095 , A61F2/2409 , A61F2/2412 , A61F2220/0075 , A61F2230/0006 , A61F2250/001
Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
Abstract translation: 一种用于组织型假体二尖瓣心脏瓣膜的改进的保持器和储存系统，其限制瓣膜的连合柱并防止缝线循环。 杆相对于保持器可轴向移动，连接缝合线的长度在连接柱顶端之间延伸以形成帐篷并向内弯曲顶端，从而有助于防止任何一组预先植入的缝合线围绕前端尖端环绕， 输送阀门。 支架具有安全机构，可在杆部署之前防止阀门传递。 一个实施例在打开储存罐时自动展开杆。 一个实施例允许递送手柄直接展开杆，而另一个使用单独的蜗杆和联接。 附接到包装套筒的保持夹可以由啮合在一起的柔性构件形成，心脏瓣膜和保持器从该夹子容易地拉开，以消除将夹子与套筒分离的步骤。
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公开(公告)号：US20140121764A1
公开(公告)日：2014-05-01
申请号：US14062424
申请日：2013-10-24
Applicant: Edwards Lifesciences Corporation
Inventor： Ruggero De Paulis , Michael C. Murad
IPC: A61F2/24
CPC classification number: A61F2/2427 , A61F2/06 , A61F2/2496
Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.
Abstract translation: 一种用于植入具有假肢心脏瓣膜的复合瓣膜导管的定尺寸工具，所述复合瓣膜导管连接到延伸到近端的导管移植物的远端上。 所述工具包括近端手柄和远侧轴，具有固定到所述轴的远端的轴线的假体心脏瓣膜分流器以及具有安装在所述心轴调节器附近的轴上的导管移植物复制品。 一种固定复合阀门导管的方法包括：向切除的升主动脉引入定径工具，用假体心脏瓣膜分选器测量主瓣环，以及确定冠状动脉是否具有足够的长度，或者是否需要额外的管状冠状动脉延伸段 通过将冠状动脉延伸到导管移植物复制品，将冠状动脉的一端或两端加入。
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公开(公告)号：US12186181B2
公开(公告)日：2025-01-07
申请号：US18113477
申请日：2023-02-23
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Michael C. Murad , Gonzalo German Angelico , Michael R. Bialas
Abstract: Balloon covers for a delivery apparatus for a prosthetic valve are disclosed. As one embodiment, a balloon cover includes first and second shell members that are configured to matingly engage with each other, each of the first and second shell members including a first portion and a second portion, the second portion having a larger width than the first portion. The first portions of the first and second shell members define a first cavity configured to receive a distal end portion of the delivery apparatus and at least a portion of an inflatable balloon mounted on the distal end portion of the delivery apparatus. The second portions of the first and second shell members define a second cavity configured to receive a positioning device mounted on the distal end portion of the delivery apparatus, proximal to a valve mounting portion of the distal end portion of the delivery apparatus.
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公开(公告)号：US12150855B2
公开(公告)日：2024-11-26
申请号：US18317741
申请日：2023-05-15
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Michael C. Murad , Hilda Z. Fann , Mark Van Nest , John X. Wang , Derrick Johnson
Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
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公开(公告)号：US20240335284A1
公开(公告)日：2024-10-10
申请号：US18747737
申请日：2024-06-19
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： JOSEPH ARTHUR PASSMAN , Linda Thai , Michael C. Murad
CPC classification number: A61F2/2433 , A61F2/2436 , A61F2/95 , A61F2/966 , A61F2/9517
Abstract: A catheter device includes a shaft having a steerable distal portion and a plurality of layers including a braided layer. A plurality of pull-wire lumens extend along a length of the shaft and are grouped together and incorporated into the braided layer in a proximal portion of the shaft. At least one pull-wire lumen of the plurality of pull-wire lumens leaves the braided layer, diverges around a circumference of the shaft to a selected angular offset, and is reincorporated into the braided layer.
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Patent Agency Ranking
公开(公告)号：US20220331100A1
公开(公告)日：2022-10-20
申请号：US17810206
申请日：2022-06-30
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , Michael C. Murad
IPC: A61F2/24
Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.
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公开(公告)号：US20220096227A1
公开(公告)日：2022-03-31
申请号：US17643750
申请日：2021-12-10
Applicant: Edwards Lifesciences Corporation
Inventor： Alain F. Carpentier , Michael C. Murad
IPC: A61F2/24
Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.
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公开(公告)号：US11197756B2
公开(公告)日：2021-12-14
申请号：US16459343
申请日：2019-07-01
Applicant: Edwards Lifesciences Corporation
Inventor： Alain F. Carpentier , Michael C. Murad
Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.
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公开(公告)号：US11185321B2
公开(公告)日：2021-11-30
申请号：US16436829
申请日：2019-06-10
Applicant: Edwards Lifesciences Corporation
Inventor： Travis Zenyo Oba , Michael C. Murad , Manouchehr A. Miraki , Anthony P. Carcia , Fabian Daniel Schroeder , Raffaele Mazzei , Tyler Douglas Smith
Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.
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公开(公告)号：US11007058B2
公开(公告)日：2021-05-18
申请号：US16052775
申请日：2018-08-02
Applicant: Edwards Lifesciences Corporation
Inventor： Michael C. Murad , Hilda Z. Fann , Mark Van Nest , John X. Wang , Derrick Johnson
Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
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