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公开(公告)号：US09090562B2
公开(公告)日：2015-07-28
申请号：US14275667
申请日：2014-05-12
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D405/12 , C07D401/00 , C07D281/02 , C07D243/08 , A61K31/00 , A61K31/55 , A61K31/445 , A61K31/44 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US20150051163A1
公开(公告)日：2015-02-19
申请号：US14394463
申请日：2013-04-12
Applicant: EPIZYME, INC.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Kevin Wayne Kuntz
IPC: C07D405/12 , A61K31/573 , A61K31/4745 , A61K31/704 , A61K31/5377 , A61K31/675
CPC classification number: C07D405/12 , A61K31/436 , A61K31/4412 , A61K31/4745 , A61K31/53 , A61K31/5377 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , C07D213/64 , A61K2300/00
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
Abstract translation: 本发明涉及包含人组蛋白甲基转移酶EZH2抑制剂和一种或多种其它治疗剂，特别是抗癌剂如泼尼松的组合物，以及用于给予需要其治疗癌症的受试者的组合疗法的方法。
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公开(公告)号：US20250109123A1
公开(公告)日：2025-04-03
申请号：US18734942
申请日：2024-06-05
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Kevin Wayne Kuntz
IPC: C07D405/12 , A61K31/436 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K45/06 , A61P35/00 , C07D213/64 , C07D413/14
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US12168014B2
公开(公告)日：2024-12-17
申请号：US16998144
申请日：2020-08-20
Applicant: Epizyme, Inc. , Eisai R&D Management Co., Ltd.
Inventor： Heike Keilhack , Brett Truitt , Yuta Suzuki , Tsukasa Murase , Futoshi Shikata
IPC: A61K9/20 , A61K9/00 , A61K9/28 , A61K31/5377 , A61P35/00
Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).
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公开(公告)号：US12162865B2
公开(公告)日：2024-12-10
申请号：US17689704
申请日：2022-03-08
Applicant: Epizyme, Inc.
Inventor： Sarah K. Knutson , Natalie Warholic , Heike Keilhack
IPC: C07D405/14 , A61K31/4412 , A61K31/4545 , A61K31/5377 , C07D211/86 , C07D405/12 , C12Q1/6886
Abstract: The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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Patent Agency Ranking
公开(公告)号：US11202781B2
公开(公告)日：2021-12-21
申请号：US16250211
申请日：2019-01-17
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Danielle Johnston Blackwell
IPC: A61K31/5377 , A61K45/06 , A61K31/4412 , A61K31/444 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/395 , A61P35/00 , G01N33/574
Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US10787440B2
公开(公告)日：2020-09-29
申请号：US16372657
申请日：2019-04-02
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Kevin Wayne Kuntz
IPC: A61K31/5377 , A61K31/4439 , C07D413/14 , A61K31/444 , A61P35/00 , C07D405/12 , A61K45/06 , A61K31/436 , A61K31/53 , A61K31/573 , A61K31/704 , A61K31/7068 , C07D213/64 , A61K31/4412 , A61K31/4745 , A61K31/675 , A61K33/24
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US10463671B2
公开(公告)日：2019-11-05
申请号：US15809445
申请日：2017-11-10
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah K. Knutson , Kevin W. Kuntz
IPC: A61K31/5377 , C07K16/28 , A61K31/573 , A61K45/06 , A61K39/395 , A61K31/69 , A61K31/675 , A61K31/635 , A61K31/404 , A61K31/52 , A61K31/519 , A61K31/4965 , A61K31/496 , A61K31/4375 , A61K31/436 , A61K39/00
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US10456407B2
公开(公告)日：2019-10-29
申请号：US15567838
申请日：2016-04-20
Applicant: Epizyme, Inc. , Health Research, Inc.
Inventor： Heike Keilhack , Roberto Pili
IPC: A61K31/711 , A61K31/5377 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/44 , A61K31/506 , A61K31/517 , A61P35/00 , A61K31/496 , A61K45/06
Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents (such as tyrosine kinase inhibitors or VEGF/VEGFR inhibitors), particularly anticancer agents such as sunitinib, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20190100514A1
公开(公告)日：2019-04-04
申请号：US15979916
申请日：2018-05-15
Applicant: Epizyme, Inc.
Inventor： Sarah K. Knutson , Natalie Warholic , Heike Keilhack
IPC: C07D405/14 , A61K31/4545 , A61K31/4412 , C12Q1/6886 , C07D405/12 , C07D211/86 , A61K31/5377
Abstract: The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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