公开(公告)号：US5695980A

公开(公告)日：1997-12-09

申请号：US470261

申请日：1995-06-06

申请人： Ying-Fei Wei ,  Ewen F. Kirkness

发明人： Ying-Fei Wei ,  Ewen F. Kirkness

IPC分类号： A61K38/00 ,  C12N9/16 ,  C12P21/04 ,  C07H19/00 ,  C07H21/02 ,  C12N15/00

CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。