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公开(公告)号：US08058467B2
公开(公告)日：2011-11-15
申请号：US13025740
申请日：2011-02-11
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07563909B2
公开(公告)日：2009-07-21
申请号：US11905910
申请日：2007-10-05
IPC分类号： C07D209/18 , B65D69/00 , B65D71/00
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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公开(公告)号：US20090030076A1
公开(公告)日：2009-01-29
申请号：US12210975
申请日：2008-09-15
IPC分类号： A61K31/215 , C07C69/22 , A61P27/02
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20080090857A1
公开(公告)日：2008-04-17
申请号：US11905893
申请日：2007-10-05
IPC分类号： A61K31/505 , A61P29/00 , A61P7/00 , A61P9/00 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US07297808B2
公开(公告)日：2007-11-20
申请号：US11590770
申请日：2006-11-01
IPC分类号： C07C205/00 , C07C331/00 , C07C203/00 , C07C381/00 , A01N37/00 , A61K31/21
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US20070072942A1
公开(公告)日：2007-03-29
申请号：US11590770
申请日：2006-11-01
申请人： Francesca Benedini , Ennio Ongini , Piero Soldato
发明人： Francesca Benedini , Ennio Ongini , Piero Soldato
IPC分类号： A61K31/21 , C07C203/00
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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公开(公告)号：US07166638B2
公开(公告)日：2007-01-23
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/40 , A61K31/401 , C07D209/10 , C07D207/325
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US20050165084A1
公开(公告)日：2005-07-28
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/21 , A61K31/40 , A61K31/404 , A61K31/405 , A61P3/06 , C07D207/34 , C07D209/10 , C07D209/24 , C07D209/26 , C07D213/55 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可以用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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39.发明申请COMPOSITION COMPRISING A NITROOXYDERIVATIVE OF ACETAMINOPHEN AND A ANTICONVULSANT DRUG FOR THE TREATMENT OF NEUROPATHIC PAIN 审中-公开含有乙酰氨基酚的硝基苯甲酸和用于治疗神经病性疼痛的抗惊厥药物的组合物公开(公告)号：US20100286264A1
公开(公告)日：2010-11-11
申请号：US12811358
申请日：2008-12-09
IPC分类号： A61K31/222 , A61P25/06 , A61P25/08
CPC分类号： A61K31/195 , A61K31/167 , A61K31/4535 , A61K2300/00
摘要： The present invention relates to compositions comprising a nitric oxide releasing paracetamol and an anticonvulsant drug. The compositions of the invention can be used use in the treatment of neuropathic pain in particular diabetic neuropathic pain, painful post-infarct syndrome, pain caused by chemotherapeutic treatment or pain arising from infections by viral agents.
摘要翻译： 本发明涉及包含一氧化氮释放对乙酰氨基酚和抗惊厥药物的组合物。 本发明的组合物可用于治疗神经性疼痛，特别是糖尿病性神经性疼痛，疼痛性梗塞后综合征，由化学治疗引起的疼痛或由病毒感染引起的疼痛。
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公开(公告)号：US20100152274A1
公开(公告)日：2010-06-17
申请号：US12594511
申请日：2008-03-19
IPC分类号： A61K31/40 , C07D207/327 , A61P9/00 , A61P29/00 , A61P7/02 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D207/34
摘要： The present invention relates to two crystalline forms designated as form A and form B, of (βR,δR)-2(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbon-yl]-1H-pyrrole-1-heptanoic acid 4-(nitrooxy)butyl ester (atorvastatin 4-(nitrooxy)butyl ester), represented by the formula (I), The invention also relates to processes for the preparation of the forms A and B, to pharmaceutical compositions comprising the two forms, and to their use for treating and/or preventing acute coronary syndromes, stroke, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.
摘要翻译： 本发明涉及两种结晶形式，其命名为（＆bgr; R，δR）-2（4-氟苯基） - ，b-，δ-二羟基-5-（1-甲基乙基）-3-苯基的形式A和形式B -4 - [（苯基氨基）碳基] -1H-吡咯-1-庚酸4-（硝基氧基）丁酯（阿托伐他汀4-（硝基氧基）丁酯），由式（I）表示，本发明还涉及 用于制备形式A和B的方法，包含两种形式的药物组合物及其用于治疗和/或预防急性冠状动脉综合征，中风，神经变性疾病如阿尔茨海默病和帕金森病以及自身免疫疾病的用途 ，如多发性硬化症。
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