利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

77 条记录 (耗时 0.022 秒)

    Amidinoureas for lowering blood pressure
    33.
    发明授权
    Amidinoureas for lowering blood pressure 失效
    用于降低血压的脒基脲

    公开(公告)号：US4219567A

    公开(公告)日：1980-08-26

    申请号：US899672

    申请日：1978-04-24

    申请人： Julius Diamond ,  Jerome J. Zalipsky

    发明人： Julius Diamond ,  Jerome J. Zalipsky

    IPC分类号： A61K31/17

    CPC分类号： A61K31/17

    摘要： This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.

    摘要翻译： 本发明描述了1-脒基-3-苯基脲的新型化合物。 还公开了制备这些化合物及其药物用途的方法。

    Xanthine compounds and method of treating bronchospastic and allergic diseases
    35.
    发明授权
    Xanthine compounds and method of treating bronchospastic and allergic diseases 失效
    黄嘌呤化合物及治疗支气管痉挛和过敏性疾病的方法

    公开(公告)号：US4120947A

    公开(公告)日：1978-10-17

    申请号：US672388

    申请日：1976-03-31

    申请人： Julius Diamond

    发明人： Julius Diamond

    IPC分类号： C07D239/54 ,  C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/06 ,  C07D239/54 ,  Y10S514/826

    摘要： Bronchial asthma and other bronchospastic and allergic diseases are treated by administering an effective amount of a substituted xanthine compound having the formula: ##STR1## wherein: R.sub.1 = C.sub.1 -C.sub.3 alkyl,R.sub.3 = c.sub.1 -c.sub.7 alkyl, C.sub.3 -C.sub.7 alkenyl, C.sub.3 -C.sub.7 alkynyl, C.sub.3 -C.sub.7 cycloalkyl or C.sub.4 -C.sub.7 cycloalkylalkyl,R.sub.8 = h, c.sub.1 -c.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl or C.sub.3 -C.sub.4 cycloalkyl,R = c.sub.1 -c.sub.4 alkyl, 2-halo C.sub.2 -C.sub.3 alkyl, or phenylNovel and preferred bronchodilator and antiallergy compounds are disclosed having the formula ##STR2## wherein: R.sub.1 = C.sub.1 -C.sub.2 alkylR.sub.3 = ch.sub.2 --(c.sub.3 -c.sub.4 alkyl),--CH.sub.2 --(C.sub.3 -C.sub.4 alkenyl), or --CH.sub.2 --(C.sub.3 -C.sub.4 cycloalkyl)R.sub.8 = h, c.sub.1 -c.sub.2 alkyl,R = c.sub.1 -c.sub.4 alkyl, 2-halo C.sub.2 -C.sub.3 alkyl, or phenylThe bronchodilator and antiallergy agents may be administered in the form of tablets, capsules or aerosols.

    摘要翻译： 通过施用有效量的具有下式的取代黄嘌呤化合物治疗支气管哮喘和其它支气管痉挛和过敏性疾病：其中：

    Carbamylguanidine antimicrobial compounds
    38.
    发明授权
    Carbamylguanidine antimicrobial compounds 失效
    氨基甘氨酸抗菌化合物

    公开(公告)号：US4115448A

    公开(公告)日：1978-09-19

    申请号：US757600

    申请日：1977-01-07

    申请人： Julius Diamond

    发明人： Julius Diamond

    IPC分类号： A61K31/17 ,  A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/35 ,  C07C67/00 ,  C07C279/24 ,  C07C279/26 ,  C07C325/00 ,  C07C335/28 ,  C07C127/19

    摘要： Antimicrobial compounds are disclosed having the formula:Z--B--Y--B--Z .nHAwherein B is carbamylguanidino, or thiocarbamylguanidino, Y is a bivalent organic radical selected from the group consisting of C.sub.2 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene, C.sub.5 -C.sub.12 cycloalkylenebis(loweralkyl), C.sub.6 -C.sub.12 arylene and loweralkylarylene, C.sub.7 -C.sub.12 aryleneloweralkyl, and C.sub.8 -C.sub.12 arylenebis(loweralkyl) and Z is selected from the group consistng of C.sub.1 -C.sub.2 alkyl; C.sub.4 -C.sub.12 dialkylaminoalkyl; C.sub.3 -C.sub.12 alkenyl; C.sub.3 -C.sub.12 alkynyl; C.sub.3 -C.sub.12 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl; C.sub.1 -C.sub.10 alkoxy C.sub.10 -C.sub.2 alkyl having a total carbon content of C.sub.3 -C.sub.14 ; C.sub.1 -C.sub.10 alkythio C.sub.10 -C.sub.2 alkyl having a total carbon content of C.sub.3 -C.sub.14 ; phenoxy C.sub.2 -C.sub.6 alkyl; phenylthio C.sub.2 -C.sub.6 alkyl; C.sub.6 -C.sub.14 aryl; C.sub.7 -C.sub.14 aralkyl and arylcycloalkyl; and C.sub.6 -C.sub.14 aryl and aralkyl substituted with one or more radicals selected from the group consisting of loweralkyl, trifluoromethyl, loweralkoxy, trifluoromethoxy, phenoxy, loweralkylthio, halo, nitro, cyano, C.sub.2 -C.sub.6 acyl, benzoyl, alkoxycarbonyl, diloweralkylamino, loweralkylsulfonyl, fluorosulfonyl and alkylsulfinyl; n=0, 1/3, 1/2, 2/3, 1, 2 and HA is an inorganic or organic acid.

    摘要翻译： 公开了具有下式的抗微生物化合物：