公开(公告)号：US06392058B1

公开(公告)日：2002-05-21

申请号：US09856201

申请日：2001-05-17

申请人： Volker Maywald ,  Adrian Steinmetz ,  Michael Rack ,  Norbert Götz ,  Roland Götz ,  Jochem Henkelmann ,  Heike Becker ,  Juan Jose Aiscar Bayeto

发明人： Volker Maywald ,  Adrian Steinmetz ,  Michael Rack ,  Norbert Götz ,  Roland Götz ,  Jochem Henkelmann ,  Heike Becker ,  Juan Jose Aiscar Bayeto

IPC分类号： C07D23120

CPC分类号： C07D231/20

摘要： The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and II in which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reacting an alkyl 3-alkoxyacrylate of the formula III in which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IV in which R1 is as defined above a) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I or b) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.

摘要翻译： 本发明涉及一种制备式I和IIin的1-取代的5-和/或3-羟基吡唑的方法，其中R 1为C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，C 3 -C 6 - 环烷基或C 1 -C 4 - 烷氧基，其中这些基团可以被卤素，C 1 -C 4 - 烷氧基，苯氧基，C 1 -C 6 - 烷氧基羰基，C 1 -C 6 - 烷硫基羰基或具有3-14个环原子的环状体系取代， 包括式IIIin的3-烷氧基丙烯酸烷基酯，其中R 2，R 3彼此独立地是C 1 -C 6烷基或C 3 -C 6环烷基与式IVin的肼，其中R 1如上所定义），其pH为6- 11得到式I的5-羟基吡唑）在11-14的pH下，得到式II的3-羟基吡唑。