公开(公告)号：US20200040057A1

公开(公告)日：2020-02-06

申请号：US16526114

申请日：2019-07-30

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko SCHUSTER ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Toni WEINSCHENK ,  Harpreet SINGH ,  Gisela SCHIMMACK ,  Michael ROEMER

IPC: C07K14/725 ,  C12N15/115 ,  C12N5/0783 ,  A61P35/00 ,  G01N33/574 ,  C07K16/28 ,  C07K14/74 ,  A61K35/17 ,  A61K9/19 ,  A61K39/00 ,  G16B25/10

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20240358757A1

公开(公告)日：2024-10-31

申请号：US18606648

申请日：2024-03-15

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240358755A1

公开(公告)日：2024-10-31

申请号：US18599888

申请日：2024-03-08

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240307447A1

公开(公告)日：2024-09-19

申请号：US18606754

申请日：2024-03-15

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240166715A1

公开(公告)日：2024-05-23

申请号：US18433919

申请日：2024-02-06

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  A61K38/00 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00 ,  C07K2319/30

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240150429A1

公开(公告)日：2024-05-09

申请号：US18417686

申请日：2024-01-19

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240141013A1

公开(公告)日：2024-05-02

申请号：US18543993

申请日：2023-12-18

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230257442A1

公开(公告)日：2023-08-17

申请号：US18305928

申请日：2023-04-24

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220306721A1

公开(公告)日：2022-09-29

申请号：US17826583

申请日：2022-05-27

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko SCHUSTER ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Toni WEINSCHENK ,  Harpreet SINGH ,  Gisela SCHIMMACK ,  Michael ROEMER

IPC: C07K14/725 ,  C12N5/0783 ,  A61P35/00 ,  G01N33/574 ,  C07K16/28 ,  C07K14/74 ,  A61K35/17 ,  A61K9/19 ,  A61K39/00 ,  G16B25/10 ,  C12N15/115

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20220098269A1

公开(公告)日：2022-03-31

申请号：US17489446

申请日：2021-09-29

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K16/28 ,  C07K14/74

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.