公开(公告)号：US20170115192A1

公开(公告)日：2017-04-27

申请号：US15397524

申请日：2017-01-03

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  David Scott Alburty ,  Alec D. Adolphson ,  Pamela S. Murowchick ,  Zachary A. Packingham

IPC: G01N1/40 ,  B01D46/00 ,  B01D46/54 ,  G01N1/22

CPC classification number: G01N1/4077 ,  B01D46/0032 ,  B01D46/0067 ,  B01D46/543 ,  G01N1/2205 ,  G01N1/2273 ,  G01N2001/4088

Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.

公开(公告)号：US20140308659A1

公开(公告)日：2014-10-16

申请号：US14313618

申请日：2014-06-24

Applicant: InnovaPrep LLC

Inventor： David S. Alburty ,  Andrew E. Page ,  Zachary A. Packingham ,  Daniel B. Marske

IPC: C12Q1/24 ,  G01N1/40

CPC classification number: C12Q1/24 ,  C12Q1/04 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.

公开(公告)号：US20140241956A1

公开(公告)日：2014-08-28

申请号：US14191205

申请日：2014-02-26

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/34

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 一次性吸头包括用于吸取样品并连接到浓缩单元的流体端口。

公开(公告)号：US20140073034A1

公开(公告)日：2014-03-13

申请号：US14084385

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: C12Q1/24

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。