公开(公告)号：US12038364B2

公开(公告)日：2024-07-16

申请号：US17156016

申请日：2021-01-22

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Julia Lodder-Gadaczek ,  Katrin Künzig ,  Franziska Frenzel ,  Tanja Uhrmacher

IPC: G01N13/00 ,  G01N1/40 ,  G01N33/15

CPC classification number: G01N13/00 ,  G01N1/4005 ,  G01N33/15 ,  G01N2001/4016 ,  G01N2013/003

Abstract: The present invention relates to an acceptor chamber for a Franz diffusion cell, comprising an upper opening closable by a membrane and, on the side wall of the acceptor chamber, an upper and a lower outlet opening designed to remove or add liquid medium from the acceptor chamber, the upper outlet opening being located within the upper two thirds of the side wall and the lower outlet opening is located in the lower quarter of the side wall, the upper and lower outlet openings being substantially opposite each other, to a Franz diffusion cell comprising a donor compartment and such an acceptor chamber, the donor compartment and the acceptor chamber being separated from each other by a membrane, and to a method for determining the diffusion of a substance through a membrane with such a Franz diffusion cell.

公开(公告)号：US12024702B2

公开(公告)日：2024-07-02

申请号：US16336441

申请日：2017-10-09

Applicant: BIOMÉRIEUX

Inventor： Fabien Dachaud ,  Jacques Dachaud ,  Frédéric Foucault ,  Edgar Minassian ,  David Mosticone ,  Jean-Claude Raymond

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/24 ,  G01N1/00 ,  G01N1/40

CPC classification number: C12M47/04 ,  C12M23/14 ,  C12M23/26 ,  C12M47/10 ,  C12Q1/24 ,  G01N1/40 ,  G01N1/405 ,  C12M47/06 ,  G01N1/4005

Abstract: A device and method preparing a sample that may contain a target microorganism, includes: placing the sample in a container including: a device for the capture and/or concentration of a target microorganism or of a protein therefrom, including a capture and/or concentration support; a receptacle including; inlet and fluid guides, a device controlling the sample volume transferred from the fluid guide to the capture and/or concentration device through the inlet orifice, an outlet orifice; the capture/concentration device being attached to a wall of the receptacle; generating a displacement of all or part of the sample to the fluid guide and a defined sample volume from the fluid guide to the capture and/or concentration device, capturing and/or concentrating, on the capture and/or concentration support, the target microorganism or a protein from the microorganism, the volume of sample crossing the capture and/or concentration support then exiting again through the outlet orifice.

公开(公告)号：US12023158B2

公开(公告)日：2024-07-02

申请号：US16891426

申请日：2020-06-03

Applicant: MANN+HUMMEL GmbH

Inventor： Dagmar Winkler ,  Heike Rupp ,  Steffen Schuetz ,  Dietmar Talmon-Gros ,  Michael Fasold ,  Alfons-Alois Schwinghammer ,  Frank Bartel ,  Sascha Bauer ,  Patrick Nytz

IPC: A61B5/15 ,  A61B5/153 ,  A61M1/34 ,  A61M1/36 ,  B01D39/20 ,  B01D63/02 ,  B01D65/00 ,  B01D67/00 ,  B01D71/02 ,  G01N1/40 ,  G01N33/49 ,  A61M1/02 ,  B01L3/00

CPC classification number: A61B5/150755 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150251 ,  A61M1/34 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3633 ,  B01D63/0233 ,  B01D63/028 ,  B01D63/031 ,  B01D65/00 ,  B01D67/0088 ,  G01N1/4005 ,  G01N33/491 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/153 ,  A61M1/0281 ,  A61M2205/3331 ,  B01D39/2068 ,  B01D2311/02 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/24 ,  B01D2313/901 ,  B01D2323/04 ,  B01D2323/20 ,  B01L3/502 ,  B01L2300/0681 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N2001/4016 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2800/22

Abstract: A whole blood filtration device is provided with a filter membrane separating a feeding volume and a clean side of the filter membrane from each other. The feeding volume communicates with a first feeding side opening and with a second feeding side opening. The filter membrane has pores with a pore size that ensures permeability of the filter membrane to blood plasma/serum and that retains blood cells. The first feeding side opening can be coupled to a first blood pump for feeding blood from the first feeding side opening into the feeding volume so that blood plasma/serum permeates the filter membrane and blood cells, retained by the filter membrane, exit from the feeding volume through the second feeding side opening.

公开(公告)号：US12007316B2

公开(公告)日：2024-06-11

申请号：US16965111

申请日：2019-01-30

Applicant: Georgia Tech Research Corporation

Inventor： Aaron C. Enten ,  Todd Sulchek

IPC: G01N1/34 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  C12M1/26 ,  C12M3/00 ,  G01N1/40

CPC classification number: G01N1/34 ,  B01D61/18 ,  B01D61/22 ,  B01D63/087 ,  C12M21/08 ,  C12M33/14 ,  G01N1/4005 ,  B01D2311/16 ,  B01D2315/08 ,  G01N2001/4088

Abstract: Embodiments of the present disclosure relate generally to dead-end filtration systems and, more particularly, to pulse-modulated periodic backflush systems and methods for clearing fouling layers in dead-end filtration systems. In some embodiments, a controller may control the flow of fluid in the system from cycling from a forward flow to a reverse flow. In some embodiments, the controller may cycle from forward to reverse flow based on a volumetric flow ratio. Embodiments of the present disclosure describe optimal volumetric flow ratios for optimizing the break of cake in a dead-end filtration system. Embodiments of the present disclosure describe optimal volumetric flow ratios for optimizing recovery percentages of targeted particles.

公开(公告)号：US11999936B2

公开(公告)日：2024-06-04

申请号：US16461007

申请日：2017-11-15

Applicant: BIOMÉRIEUX

Inventor： Patrick Broyer ,  Marie-Hélène Charles ,  Jérôme Blaze ,  Nadine Perrot ,  Frédéric Pinston ,  Hervé Rostaing

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/26 ,  C12M1/32 ,  C12M3/06 ,  G01N33/00 ,  G01N33/68 ,  G16B20/00 ,  B01L9/06 ,  G01N1/40 ,  G01N35/04

CPC classification number: C12M33/14 ,  B01L3/502 ,  C12M23/12 ,  C12M23/16 ,  G01N33/6848 ,  G16B20/00 ,  B01L9/06 ,  G01N1/4005 ,  G01N2035/0436

Abstract: An extraction system includes a support bar including a sample well, a reagent well, at least one washing well, and at least one protection and retention housing; a pipetting element removably mounted on the support bar and extending at least partially into the at least one protection and retention housing; and a filtering and transfer device configured to capture and accumulate microorganisms contained in the sample and transfer the captured and accumulated microorganisms, the filtering and transfer device being removably mounted on the support bar and extending at least partially into the at least one protection and retention housing. The filtering and transfer device includes a hollow body having an elongated shape and including a proximal end portion and a distal end portion; and a filtering element fixed to the distal end portion of the hollow body.

公开(公告)号：US11959841B2

公开(公告)日：2024-04-16

申请号：US16476329

申请日：2018-01-08

Applicant: University of Rochester

Inventor： James Lionel McGrath ,  Kilean Scott Lucas ,  Henry Hung Li Chung

IPC: G01N1/40 ,  B01D69/02 ,  B01D71/02 ,  B01D71/52 ,  C12N15/10

CPC classification number: G01N1/4005 ,  B01D69/02 ,  B01D71/02 ,  B01D71/52 ,  C12N15/1017 ,  B01D2325/027 ,  B01D2325/42 ,  G01N2001/4016

Abstract: A device and method for isolating extracellular vesicles from biofluids is disclosed. A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid. A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.

公开(公告)号：US20240102901A1

公开(公告)日：2024-03-28

申请号：US18373110

申请日：2023-09-26

Applicant: SALUS DISCOVERY, LLC

Inventor： Jay Warrick ,  Cody Carrell ,  Brianna Mullins ,  David Beebe ,  Ryan Shogren ,  Patrick McMinn ,  Mitch Geiger ,  Madalyn Gill ,  Jeffrey Robert Staszak ,  Visnu Devi Fraenkel ,  Antonio Gatta ,  Eric S. Mackey ,  McKayla Rae Barber ,  Randi Marie Degg ,  Madeline Sides ,  Douglas Paul Barnes ,  Franklin Cheng Zhong ,  Mindy Phung

IPC: G01N1/40 ,  G01N33/493

CPC classification number: G01N1/4005 ,  G01N33/493 ,  G01N2001/4088

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

公开(公告)号：US20240102900A1

公开(公告)日：2024-03-28

申请号：US18530661

申请日：2023-12-06

Applicant: Shenzhen Huixin Life Technologies Co., Ltd.

Inventor： YUCHAO CHEN

IPC: G01N1/34 ,  G01N1/40

CPC classification number: G01N1/34 ,  G01N1/4005 ,  G01N2001/4016

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

公开(公告)号：US20240094171A1

公开(公告)日：2024-03-21

申请号：US18468288

申请日：2023-09-15

Applicant: Wyatt Technology, LLC

Inventor： Steven P. Trainoff

IPC: G01N30/00 ,  G01N1/40

CPC classification number: G01N30/0005 ,  G01N1/4005 ,  G01N2030/007

Abstract: A continuous field flow fractionator includes a sample inject port, a frit inlet port, a first fraction outlet port, a second fraction outlet port, and a third fraction outlet port. A first flow out of the first fraction outlet port is configured to extract a sample-free solvent. A second flow out of the second fraction outlet port is configured to extract an increased concentration of small molecules of a sample. A third flow out of the third faction port is configured to extract a remainder of the sample.

公开(公告)号：US20240094100A1

公开(公告)日：2024-03-21

申请号：US18468171

申请日：2023-09-15

Applicant: Wyatt Technology, LLC

Inventor： David Rahmlow

IPC: G01N1/40

CPC classification number: G01N1/4005

Abstract: A continuous field flow fractionator includes a membrane, a bottom plate assembly and a top plate assembly that includes an inject port, an inlet port, at least one orthogonal flow inlet port, at least one orthogonal flow outlet port, and at least two sample outlet ports. The top plate assembly, the membrane, and the bottom plate assembly define a separation channel. The solvent flowing from the at least one orthogonal flow inlet port impinges on particles of a sample flowing between the inject port to the at least two sample outlet ports in the orthogonal flow region. The particles of the sample flow to the at least two sample outlet ports according to sizes of the particles of the sample, resulting in fractions of the sample in accordance with the sizes of the particles.