摘要:
The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
The present invention relates to a method of degreasing skins and hides with certain variants of Humicola lanuginose lipase. More specifically, the invention relates to a process for enzymatic degreasing of skins and hides with lipase in the absence of surfactant at pH 6-13.
摘要:
Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase.
摘要:
A method and system for segmentation of the corpus callosum in MR brain images is disclosed. The method utilizes an active shape model (ASM) with confidence weighting to iteratively adjust an initial corpus callosum contour to define a boundary of the corpus callosum in an MR image. An ASM is used to determine a displacement value in a perpendicular direction of the corpus callosum contour for each node of the corpus callosum contour. The displacement value for each node is then weighted based on a confidence of that displacement value. The ASM is then fitted to the adjusted contour. These steps are iteratively performed until the contour converges to define the corpus callosum boundary. This boundary can be further refined based on intensity distributions in object and background regions defined by the boundary.
摘要:
The present disclosure provides a display module, an electronic device and a control method thereof. The display module may comprise: a covering unit satisfying a first light transmittance, comprising a touch area; a sensing unit satisfying a second light transmittance, comprising a sensing layer, wherein the covering unit is arranged on a first side of the sensing layer, and the sensing layer is configured to sense a touch position of an operator in the touch area when the operator touches the touch area; a reflective type display unit, comprising a display layer and a reflective surface, wherein the display unit is arranged on a second side of the sensing layer, and the display layer and the reflective surface are respectively opposite to the sensing layer. The display unit displays images through the display layer, and a distance between the reflective surface and the sensing unit is larger than or equal to a distance between the display layer and the sensing unit, wherein an incident light arriving at the reflective surface forms a reflected light capable of transmitting through the sensing unit and the covering unit.
摘要:
The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
Wavelength-based optical power provisioning is provided by multiplexing a plurality of continuous wave light beams at different wavelengths onto a single optical fiber as a multiplexed light source and demultiplexing the multiplexed light source based on wavelength at a photonic unit coupled to the optical fiber to recover the continuous wave light beams. The recovered continuous wave light beams are split into a plurality of light beams by the photonic unit, each light beam having the same wavelength and the same or lower power as one of the recovered continuous wave light beams so that at least one of the light beams generated by the photonic unit has a higher power than the other light beams generated by the photonic unit.
摘要:
The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
The present invention is generally related to an electronic ballast, an ignition control apparatus used therein and associated method of operation. In one embodiment, an electronic ballast comprising an inverter and an ignition control apparatus which comprises a stability monitoring circuit and a controlled ignition circuit. The inverter converts a DC input voltage into an AC voltage to drive a gas discharge lamp. The stability monitoring circuit monitors whether the DC input voltage is stable. The controlled ignition circuit is electrically coupled to the stability monitoring circuit and the lamp, ignites the lamp based on the monitoring result. The controlled ignition circuit does not ignite the gas discharge lamp until the DC input voltage becomes stable.