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公开(公告)号：US08929969B2
公开(公告)日：2015-01-06
申请号：US12533264
申请日：2009-07-31
CPC分类号： A61M25/0009 , A61B5/0422 , A61M25/0043
摘要： A catheter assembly for use in an anatomy can include an elongated body, which can have a proximal end and a distal end. The body can also define a lumen from the proximal end to the distal end. The assembly can include at least one electrode, which can be coupled to the distal end to sense an electrical activity within the anatomy. The assembly can include a core wire, which can be received within the lumen from the proximal end to the distal end. The core wire can be configured to move the distal end from a first configuration to a second configuration. The assembly can also include a necked portion, which can be formed between the proximal end and the distal end to provide increased stiffness to the distal end of the body.
摘要翻译： 用于解剖结构的导管组件可包括细长体，其可具有近端和远端。 身体还可以限定从近端到远端的内腔。 组件可以包括至少一个电极，其可以耦合到远端以感测解剖结构内的电活动。 该组件可以包括芯线，该芯线可以从该近端容纳在该内腔中至该远端。 芯线可以被配置为将远端从第一配置移动到第二配置。 组件还可以包括颈部，其可以在近端和远端之间形成，以向身体的远端提供增加的刚度。
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公开(公告)号：US08776799B2
公开(公告)日：2014-07-15
申请号：US13053025
申请日：2011-03-21
申请人： Edward M. Gillis , John H. Shadduck
发明人： Edward M. Gillis , John H. Shadduck
CPC分类号： A61F5/56 , A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for revisably treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, first and second openings extend through first and second implant ends, respectively, for permitting a tissue plug to grow through each opening. Methods of using and revising such systems are also provided.
摘要翻译： 提供了一种用于可修复地治疗气道障碍的系统，植入体被构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，第一和第二开口分别延伸穿过第一和第二植入端，以允许组织塞通过每个开口生长。 还提供了使用和修改这种系统的方法。
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33.发明授权公开(公告)号：US08523760B2
公开(公告)日：2013-09-03
申请号：US13443839
申请日：2012-04-10
申请人： Edward M. Gillis
发明人： Edward M. Gillis
IPC分类号： A61F2/00
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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公开(公告)号：US08086293B2
公开(公告)日：2011-12-27
申请号：US12533252
申请日：2009-07-31
申请人： Gary Boseck , Edward M. Gillis
发明人： Gary Boseck , Edward M. Gillis
CPC分类号： A61B5/042 , A61B18/1492 , A61M25/0043 , A61M25/09 , A61M2025/0681 , A61M2025/09183
摘要： A catheter includes an outer jacket, a shaft member, a transition member and a core member. The outer jacket has a first interior passage at a proximal end and a second interior passage at a distal end. The shaft member is arranged within the outer jacket. The transition member is fixedly secured to the shaft member and includes a window. The core member is fixedly secured to the transition member. The window in the transition member allows communication between the first interior passage and the second interior passage.
摘要翻译： 导管包括外护套，轴构件，过渡构件和芯构件。 外护套在近端具有第一内部通道，在远端具有第二内部通道。 轴构件布置在外护套内。 过渡构件固定地固定到轴构件并且包括窗口。 芯构件固定地固定到过渡构件。 过渡构件中的窗口允许第一内部通道和第二内部通道之间的连通。
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公开(公告)号：US20110308530A1
公开(公告)日：2011-12-22
申请号：US13113946
申请日：2011-05-23
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has first and second end portions and a medial portion. The implant body also includes a coupler configured to couple the end portions to one another such that the medial portion encircles targeted tissue. Methods of using such systems are also provided.
摘要翻译： 一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，植入体具有第一和第二端部和中间部分。 植入体还包括耦合器，其被配置为将端部部分彼此耦合，使得内侧部分围绕目标组织。 还提供了使用这种系统的方法。
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36.发明授权公开(公告)号：US06648873B2
公开(公告)日：2003-11-18
申请号：US09960558
申请日：2001-09-21
IPC分类号： A61M3100
CPC分类号： A61F11/00 , A61M25/04 , A61M25/10 , A61M2210/0668
摘要： Methods and apparatus used for securing the end of a drug-delivery catheter at the round window niche of the inner ear; specifically an apparatus employing a miniature threaded screw pump to inflate a balloon allowing a catheter to be secured within the round window niche of the inner ear.
摘要翻译： 用于将药物输送导管的末端固定在内耳的圆窗口处的方法和装置; 具体地，使用微型螺纹螺杆泵来使气囊膨胀的装置，其允许导管固定在内耳的圆形窗口内。
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37.发明授权
公开(公告)号：US5656029A
公开(公告)日：1997-08-12
申请号：US383462
申请日：1995-02-08
CPC分类号： A61M25/0144 , A61B18/1492 , A61M25/0136 , A61M25/0147 , A61M25/0158 , A61B2017/003 , A61B2017/00867 , A61B2018/00351 , A61B2018/00577 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/1253 , A61B2018/1467
摘要： A steerable catheter comprising a flexible elongate tubular member having proximal and distal extremities. A handle is secured to the proximal extremity. The tubular member has a lumen extending therethrough. A mandrel is slidably mounted in the lumen and extends into the distal extremity. A pull wire extends through the tubular member for causing bending of the distal extremity with respect to the mandrel disposed therein.
摘要翻译： 导管，其包括具有近端和远端的柔性细长管状构件。 手柄固定在近端。 管状构件具有延伸穿过其中的内腔。 心轴可滑动地安装在内腔中并延伸到远端。 拉线延伸通过管状构件，用于相对于设置在其中的心轴弯曲远端。
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公开(公告)号：US09510922B2
公开(公告)日：2016-12-06
申请号：US13113946
申请日：2011-05-23
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： An implant for treating an obstructive airway disorder includes an elongate implant body configured for implanting in airway-interface tissue. At least a portion of the elongate body carries a light transmission material for permitting light transmission therein. Systems and methods of treating an airway disorder including implanting an implant in an airway-interface tissue are also provided.
摘要翻译： 用于治疗阻塞性气道障碍的植入物包括构造成用于植入气道界面组织中的细长植入体。 细长体的至少一部分携带用于允许光透射的透光材料。 还提供了治疗气道障碍的系统和方法，包括将植入物植入气道界面组织中。
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公开(公告)号：US20140007885A1
公开(公告)日：2014-01-09
申请号：US13935052
申请日：2013-07-03
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： Methods for treating sleep apnea. A method includes implanting at least first and second elongated implants in a tongue or soft palate of a patient, wherein each of the first and second implants is configured to have a first, expanded configuration and a second, contracted configuration, wherein implanting comprises implanting the first and second implants having their first, expanded configurations. The invention also provides systems for treating sleep apnea that can be used with the methods.
摘要翻译： 睡眠呼吸暂停治疗方法 一种方法包括将至少第一和第二细长植入物植入患者的舌或软腭中，其中第一和第二植入物中的每一个被配置为具有第一扩张构型和第二收缩构造，其中植入包括植入 第一和第二植入物具有其第一，扩展的构型。 本发明还提供了用于治疗可与该方法一起使用的睡眠呼吸暂停的系统。
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40.发明申请公开(公告)号：US20130312767A1
公开(公告)日：2013-11-28
申请号：US13954589
申请日：2013-07-30
申请人： Edward M. Gillis
发明人： Edward M. Gillis
IPC分类号： A61F5/56
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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