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公开(公告)号：US08929969B2
公开(公告)日：2015-01-06
申请号：US12533264
申请日：2009-07-31
CPC分类号： A61M25/0009 , A61B5/0422 , A61M25/0043
摘要： A catheter assembly for use in an anatomy can include an elongated body, which can have a proximal end and a distal end. The body can also define a lumen from the proximal end to the distal end. The assembly can include at least one electrode, which can be coupled to the distal end to sense an electrical activity within the anatomy. The assembly can include a core wire, which can be received within the lumen from the proximal end to the distal end. The core wire can be configured to move the distal end from a first configuration to a second configuration. The assembly can also include a necked portion, which can be formed between the proximal end and the distal end to provide increased stiffness to the distal end of the body.
摘要翻译： 用于解剖结构的导管组件可包括细长体，其可具有近端和远端。 身体还可以限定从近端到远端的内腔。 组件可以包括至少一个电极，其可以耦合到远端以感测解剖结构内的电活动。 该组件可以包括芯线，该芯线可以从该近端容纳在该内腔中至该远端。 芯线可以被配置为将远端从第一配置移动到第二配置。 组件还可以包括颈部，其可以在近端和远端之间形成，以向身体的远端提供增加的刚度。
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公开(公告)号：US20100261990A1
公开(公告)日：2010-10-14
申请号：US12533264
申请日：2009-07-31
CPC分类号： A61M25/0009 , A61B5/0422 , A61M25/0043
摘要： A catheter assembly for use in an anatomy can include an elongated body, which can have a proximal end and a distal end. The body can also define a lumen from the proximal end to the distal end. The assembly can include at least one electrode, which can be coupled to the distal end to sense an electrical activity within the anatomy. The assembly can include a core wire, which can be received within the lumen from the proximal end to the distal end. The core wire can be configured to move the distal end from a first configuration to a second configuration. The assembly can also include a necked portion, which can be formed between the proximal end and the distal end to provide increased stiffness to the distal end of the body.
摘要翻译： 用于解剖结构的导管组件可包括细长体，其可具有近端和远端。 身体还可以限定从近端到远端的内腔。 组件可以包括至少一个电极，其可以耦合到远端以感测解剖结构内的电活动。 该组件可以包括芯线，该芯线可以从该近端容纳在该内腔中至该远端。 芯线可以被配置为将远端从第一配置移动到第二配置。 组件还可以包括颈部，其可以在近端和远端之间形成，以向身体的远端提供增加的刚度。
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公开(公告)号：US09463112B2
公开(公告)日：2016-10-11
申请号：US11592429
申请日：2006-11-03
申请人： Andres D. Tomas , Ryan P. Boucher , Edward M. Gillis , Scott A. McGill , Lionel M. Nelson , Joe Paraschac
发明人： Andres D. Tomas , Ryan P. Boucher , Edward M. Gillis , Scott A. McGill , Lionel M. Nelson , Joe Paraschac
IPC分类号： A61F5/56
摘要： A carrier is sized and configured for placement in or on a tissue region. The carrier includes at least one interior compartment. At least one ferromagnetic material is carried within the compartment. The compartment and the ferromagnetic material are mutually sized and configured to allow movement of the ferromagnetic material within the compartment in response to magnetic interaction with a magnetic material located outside the carrier. The magnetic interaction can include either a magnetic attracting force or a magnetic repelling force. The carrier can be used in association with a source of magnetism sized and configured for placement in or on a tissue region outside the carrier for magnetic interaction with the ferromagnetic material carried within the compartment, e.g., to stabilize the orientation of a tissue region within an airway.
摘要翻译： 载体的尺寸和构造适于放置在组织区域中或组织区域上。 载体包括至少一个内部隔室。 至少一个铁磁材料被携带在隔间内。 隔室和铁磁材料相互尺寸和构造成允许响应于位于载体外部的磁性材料的磁相互作用而使铁磁材料在隔间内移动。 磁相互作用可以包括磁吸引力或磁排斥力。 载体可以与尺寸和构造用于放置在载体外部的组织区域中或其上的磁性源结合使用，以与在隔室内承载的铁磁材料磁性相互作用，例如以稳定组织区域内的取向 气道。
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4.发明授权Devices, systems and methods using magnetic force systems affecting both the tongue and the soft palate/uvula in the upper airway 失效使用影响上呼吸道舌头和软腭/尿道的磁力系统的装置，系统和方法公开(公告)号：US08528564B2
公开(公告)日：2013-09-10
申请号：US11592562
申请日：2006-11-03
申请人： Joseph Paraschac , Ryan P. Boucher , Edward M. Gillis , Andrew W. Kramer , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
发明人： Joseph Paraschac , Ryan P. Boucher , Edward M. Gillis , Andrew W. Kramer , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
IPC分类号： A61F5/56
摘要： Systems and methods resist posterior movement of both the tongue and the soft palate/uvula during sleep, thereby keeping an airway open. The systems and methods employ first, second, and third structures. The first structure is sized and configured for placement in or on a tongue. The second structure is sized and configured for placement in or on a region of a soft palate or uvula. The third structure is sized and configured for placement in or on tissue in a desired relationship. anterior of the first and second structures. The first and second structures each includes a ferromagnetic material. The third structure includes a magnetic material that magnetically interacts with both the first and second ferromagnetic materials by attracting both the first and second ferromagnetic materials, thereby resisting posterior movement of both the tongue and the soft palate/uvula.
摘要翻译： 系统和方法可防止睡眠期间舌和软腭/尿囊的后移，从而保持呼吸道畅通。 系统和方法采用第一，第二和第三结构。 第一个结构的大小和配置用于放置在舌头上或舌头上。 第二结构的尺寸和构造用于放置在软腭或尿囊的区域中或上。 第三结构的尺寸和构造用于以期望的关系放置在组织中或组织上。 第一和第二结构的前面。 第一和第二结构各自包括铁磁材料。 第三结构包括磁性材料，其通过吸引第一和第二铁磁材料两者而与第一和第二铁磁材料两者磁性相互作用，从而抵抗舌和软腭/囊的后运动。
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5.发明授权公开(公告)号：US08167787B2
公开(公告)日：2012-05-01
申请号：US11969201
申请日：2008-01-03
申请人： Edward M. Gillis
发明人： Edward M. Gillis
IPC分类号： A61F2/00
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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公开(公告)号：US08047206B2
公开(公告)日：2011-11-01
申请号：US11404631
申请日：2006-04-14
IPC分类号： A61F13/00
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue. The magnetic structures include magnetic materials that are sized, configured, and arranged on at least one of the first and second magnetic structures, to maintain a substantially mutually repelling orientation between the first and second magnetic structures during a native range of movement of the tongue relative to the pharyngeal wall, i.e., during swallowing and/or drinking/and or speech.
摘要翻译： 磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。 磁性结构包括磁性材料，其尺寸，构造和布置在第一和第二磁性结构中的至少一个上，以在舌形相对的自然运动范围内在第一和第二磁性结构之间保持基本相互排斥的取向 到咽壁，即在吞咽和/或饮酒和/或言语期间。
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7.发明授权Devices, systems and methods using magnetic force systems affecting the tongue or hyoid muscles in the upper airway 有权使用磁力系统的装置，系统和方法影响上呼吸道中的舌头或hy肌公开(公告)号：US08020560B2
公开(公告)日：2011-09-20
申请号：US11592637
申请日：2006-11-03
申请人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
发明人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems and methods are provided for resisting posterior movement of the tongue during sleep, thereby keeping an airway open. The systems and methods employ a first structure that can be placed either in or on a tongue within an oral cavity and/or in a region of hyoid muscle. The first structure includes a ferromagnetic material. The systems and methods employ a second structure that can be placed either in or on external tissue outside the oral cavity and/or in or on external tissue outside the oral cavity in a desired relationship with the first structure. The second structure includes a magnetic material that magnetically interacts with the ferromagnetic material by attracting the ferromagnetic material, thereby resisting posterior movement of the tongue.
摘要翻译： 提供了系统和方法，用于抵抗睡眠期间舌头的后运动，从而保持呼吸道畅通。 该系统和方法采用可以放置在口腔内和/或舌骨区域内或舌上的第一结构。 第一结构包括铁磁材料。 该系统和方法采用第二结构，该第二结构可以以与第一结构的期望的关系置于口腔外部和/或外部组织外部和/或外部组织中或外部组织中。 第二结构包括通过吸引铁磁材料与铁磁材料磁性相互作用的磁性材料，从而抵抗舌头的后部运动。
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公开(公告)号：US06014579A
公开(公告)日：2000-01-11
申请号：US897657
申请日：1997-07-21
申请人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
发明人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
IPC分类号： A61B5/042 , A61B5/0408 , A61N1/05
CPC分类号： A61B5/6858 , A61B5/0422 , A61B2562/0209 , A61B2562/043
摘要： An endocardial mapping catheter for introduction into a chamber of a heart formed by a wall. The flexible elongate tubular member has proximal and distal extremities and extends along a longitudinal axis. A plurality of longitudinally-extending spaced-apart members are carried by the distal extremity of the flexible elongate tubular member and have proximal extremities and interconnected distal extremities. Certain of the plurality of longitudinally-extending members are arms of a basket-like assembly and are movable between contracted positions and expanded positions in which the arms bow outwardly from the longitudinal axis. A plurality of longitudinally spaced-apart electrodes are carried by each of the arms. Electrical conductors extend through the flexible elongate tubular member and are connected to the electrodes for performing electrical functions with respect to the electrodes. At least one additional electrode is slidably mounted on one of the longitudinally-extending members.
摘要翻译： 用于引入由壁形成的心脏室的心内膜定位导管。 柔性细长管状构件具有近端和远端，并且沿着纵向轴线延伸。 多个纵向延伸的间隔开的构件由柔性细长管状构件的远端承载并且具有近端和相互连接的远端。 多个纵向延伸的构件中的某些是篮状组件的臂，并且可以在收缩位置和扩展位置之间移动，在该位置中臂从纵向轴线向外伸出。 多个纵向间隔开的电极由每个臂承载。 电导体延伸穿过柔性细长管状构件并且连接到电极以相对于电极执行电功能。 至少一个附加电极可滑动地安装在一个纵向延伸部件上。
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公开(公告)号：US09439801B2
公开(公告)日：2016-09-13
申请号：US13539081
申请日：2012-06-29
申请人： Edward M. Gillis , Csaba Truckai , Paul J. Buscemi
发明人： Edward M. Gillis , Csaba Truckai , Paul J. Buscemi
CPC分类号： A61F5/566 , A61F2/00 , A61F2210/0004 , A61F2250/0018 , Y10T29/49826
摘要： Methods of maintaining airway patency in an airway of a patient. A method includes the steps of wrapping a bioerodable material at least partway around an axis to create a wound bioerodable implant, and coupling two points on the bioerodable material to each other. The invention also provides systems for maintaining airway patency in an airway of a patient that may be used with the methods.
摘要翻译： 维持患者气道通气通畅的方法。 一种方法包括以下步骤：将至少一部分可生物侵蚀的材料缠绕在轴线周围以产生缠绕的可生物侵蚀的植入物，并将可生物侵蚀的材料上的两个点彼此连接。 本发明还提供了可以与该方法一起使用的用于维持患者气道中的气道通畅的系统。
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10.发明授权公开(公告)号：US08590537B2
公开(公告)日：2013-11-26
申请号：US11404598
申请日：2006-04-14
申请人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy , Ronald G. Lax
发明人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy , Ronald G. Lax
CPC分类号： A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/009
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue.
摘要翻译： 磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。
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