"> N-[3-(1'-3
    31.
    发明授权
    N-[3-(1'-3"-O xapentamethylene-amino-ethylideneamino)-2,4,6-triiodobenzoyl]-.beta.-amin o-.alpha.- methylpropionitrile in process to make corresponding acid 失效
    N- [3-(1'-3“ - 亚氧杂亚麻基 - 氨基 - 亚乙基氨基)-2,4,6-三碘苯甲酰基]-β-氨基-α-甲基丙腈在制备相应的酸

    公开(公告)号:US4375543A

    公开(公告)日:1983-03-01

    申请号:US288200

    申请日:1981-07-29

    CPC分类号: C07D295/195 C07C255/00

    摘要: The present invention relates to the novel compound N-[3-(1'-3"-Oxapentamethyleneamino-ethylideneamino)-2,4,6-triiodobenzoyl]-.beta.-amino-.alpha.methylpropionitrile which due to the sparing solubility in water, can be purified readily in a simple manner and can be used for the preparation of the known active compound for agents for peroral rapid cholecystography N-[3-(1'-3"-oxapentamethyleneamino-ethylideneamino)-2,4,6-triiodobenzoyl]-.beta.-amino-.alpha.-methyl propionic acid.

    摘要翻译: 本发明涉及新型化合物N- [3-(1'-3“ - 亚氧杂亚戊基氨基 - 亚乙基氨基)-2,4,6-三碘苯甲酰基]-β-氨基-α甲基丙腈,其由于在水中的保留溶解度 可以以简单的方式容易地纯化,并且可以用于制备用于口腔快速胆囊造影剂的已知活性化合物N- [3-(1'-3“ - 氧杂亚戊基亚氨基 - 亚乙基氨基)-2,4,6 三碘苯甲酰基]-β-氨基-α-甲基丙酸。

    Crystalline form C of tigecycline dihydrochloride and methods for its preparation
    37.
    发明授权
    Crystalline form C of tigecycline dihydrochloride and methods for its preparation 有权
    替加环素二盐酸盐的结晶形式C及其制备方法

    公开(公告)号:US08513224B2

    公开(公告)日:2013-08-20

    申请号:US13133164

    申请日:2009-12-18

    CPC分类号: C07C237/26 C07C2603/46

    摘要: The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline form C of Tigecycline dihydrochloride as an intermediate for the preparation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form C of Tigecycline dihydrochloride in an effective amount and to the use of crystalline form C of Tigecycline dihydrochloride as an anti-infective medicament.

    摘要翻译: 本发明涉及替加环素二盐酸盐的结晶形式C及其制备方法。 此外,本发明涉及替加环素二盐酸盐的结晶形式C作为制备抗感染药物的中间体的用途。 此外,本发明涉及有效量的包含替加环素二盐酸盐的结晶形式C的药物组合物和使用替加环素二盐酸盐的结晶形式C作为抗感染药物。

    CRYSTALLINE FORMS OF TIGECYCLINE HYDROCHLORIDE
    38.
    发明申请
    CRYSTALLINE FORMS OF TIGECYCLINE HYDROCHLORIDE 审中-公开
    TIGECYCLINE HYDROCHLORIDE的结晶形式

    公开(公告)号:US20130012481A1

    公开(公告)日:2013-01-10

    申请号:US13550665

    申请日:2012-07-17

    IPC分类号: C07C50/36 A61P31/00 A61K31/65

    摘要: The present invention relates to crystalline forms A and B of Tigecycline hydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline forms A and B of Tigecycline hydrochloride as intermediates for the formulation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form A of Tigecycline hydrochloride in an effective amount and to the use of crystalline form A of Tigecycline hydrochloride as anti-infective medicament.

    摘要翻译: 本发明涉及盐酸替加环素的结晶形式A和B及其制备方法。 此外,本发明涉及盐酸替加环素的结晶形式A和B在制备抗感染药物中的用途。 此外,本发明涉及包含有效量的盐酸替加环素的结晶形式A和使用盐酸替加环素的结晶形式A作为抗感染药物的药物组合物。

    ANTIBIOTIC COMPOUNDS
    40.
    发明申请
    ANTIBIOTIC COMPOUNDS 审中-公开
    抗生素化合物

    公开(公告)号:US20110124893A1

    公开(公告)日:2011-05-26

    申请号:US12863654

    申请日:2009-01-19

    IPC分类号: C07C237/26

    摘要: The present invention relates to the new crystalline solid form XI of Tigecycline and a process of preparing the same. Form XI of Tigecycline is particularly suitable for the isolation of Tigecycline in the last step of the synthesis of Tigecycline. Further the present invention relates to a process of preparing amorphous Tigecycline by spray drying form XI or another crystalline form of Tigecycline.

    摘要翻译: 本发明涉及替加环素的新结晶固体XI型及其制备方法。 替加环素的XI型XI特别适用于替加环素合成最后一步中替加环素的分离。 本发明还涉及通过XI型喷雾干燥或替加环素的另一结晶形式制备非晶替加环素的方法。