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1.发明申请CRYSTALLINE FORM C OF TIGECYCLINE DIHYDROCHLORIDE AND METHODS FOR ITS PREPARATION 有权二乙基二氯化锆的结晶形式及其制备方法公开(公告)号：US20120022025A1
公开(公告)日：2012-01-26
申请号：US13133164
申请日：2009-12-18
IPC分类号： C07C237/26 , A61P31/00 , A61K31/65
CPC分类号： C07C237/26 , C07C2603/46
摘要： The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline form C of Tigecycline dihydrochloride as an intermediate for the preparation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form C of Tigecycline dihydrochloride in an effective amount and to the use of crystalline form C of Tigecycline dihydrochloride as an anti-infective medicament.
摘要翻译： 本发明涉及替加环素二盐酸盐的结晶形式C及其制备方法。 此外，本发明涉及替加环素二盐酸盐的结晶形式C作为制备抗感染药物的中间体的用途。 此外，本发明涉及有效量的包含替加环素二盐酸盐的结晶形式C的药物组合物和使用替加环素二盐酸盐的结晶形式C作为抗感染药物。
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2.发明授权Crystalline form C of tigecycline dihydrochloride and methods for its preparation 有权替加环素二盐酸盐的结晶形式C及其制备方法公开(公告)号：US08513224B2
公开(公告)日：2013-08-20
申请号：US13133164
申请日：2009-12-18
IPC分类号： A01N37/18 , A61K31/65 , C07C43/00 , C07C49/00 , C07C237/26
CPC分类号： C07C237/26 , C07C2603/46
摘要： The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline form C of Tigecycline dihydrochloride as an intermediate for the preparation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form C of Tigecycline dihydrochloride in an effective amount and to the use of crystalline form C of Tigecycline dihydrochloride as an anti-infective medicament.
摘要翻译： 本发明涉及替加环素二盐酸盐的结晶形式C及其制备方法。 此外，本发明涉及替加环素二盐酸盐的结晶形式C作为制备抗感染药物的中间体的用途。 此外，本发明涉及有效量的包含替加环素二盐酸盐的结晶形式C的药物组合物和使用替加环素二盐酸盐的结晶形式C作为抗感染药物。
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公开(公告)号：US20110124893A1
公开(公告)日：2011-05-26
申请号：US12863654
申请日：2009-01-19
IPC分类号： C07C237/26
CPC分类号： C07C237/26 , C07B2200/13 , C07C231/24
摘要： The present invention relates to the new crystalline solid form XI of Tigecycline and a process of preparing the same. Form XI of Tigecycline is particularly suitable for the isolation of Tigecycline in the last step of the synthesis of Tigecycline. Further the present invention relates to a process of preparing amorphous Tigecycline by spray drying form XI or another crystalline form of Tigecycline.
摘要翻译： 本发明涉及替加环素的新结晶固体XI型及其制备方法。 替加环素的XI型XI特别适用于替加环素合成最后一步中替加环素的分离。 本发明还涉及通过XI型喷雾干燥或替加环素的另一结晶形式制备非晶替加环素的方法。
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公开(公告)号：US08252946B2
公开(公告)日：2012-08-28
申请号：US12742706
申请日：2008-11-12
申请人： Josef Wieser , Andreas Hotter , Arthur Pichler
发明人： Josef Wieser , Andreas Hotter , Arthur Pichler
IPC分类号： C07C237/26
CPC分类号： C07C237/26 , C07B2200/13 , C07C2603/46
摘要： The present invention relates to crystalline forms A and B of Tigecycline hydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline forms A and B of Tigecycline hydrochloride as intermediates for the formulation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form A of Tigecycline hydrochloride in an effective amount and to the use of crystalline form A of Tigecycline hydrochloride as anti-infective medicament.
摘要翻译： 本发明涉及盐酸替加环素的结晶形式A和B及其制备方法。 此外，本发明涉及盐酸替加环素的结晶形式A和B在制备抗感染药物中的用途。 此外，本发明涉及包含有效量的盐酸替加环素的结晶形式A和使用盐酸替加环素的结晶形式A作为抗感染药物的药物组合物。
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公开(公告)号：US08435998B2
公开(公告)日：2013-05-07
申请号：US12993351
申请日：2009-06-25
IPC分类号： A61K31/496 , C07D405/14
CPC分类号： C07D405/06 , C07D405/14
摘要： The present invention relates to crystalline form IV of posaconazole and pharmaceutical compositions comprising the same. The pharmaceutical composition can be used to treat or prevent fungal infections.
摘要翻译： 本发明涉及泊沙康唑的结晶形式IV及包含其的药物组合物。 药物组合物可用于治疗或预防真菌感染。
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6.发明申请公开(公告)号：US20110105525A1
公开(公告)日：2011-05-05
申请号：US12993297
申请日：2009-05-28
申请人： Josef Wieser , Arthur Pichler , Andreas Hotter , Ulrich Griesser , Christoph Langes , Christian Laschober
发明人： Josef Wieser , Arthur Pichler , Andreas Hotter , Ulrich Griesser , Christoph Langes , Christian Laschober
IPC分类号： A61K31/496 , C07D405/14 , A61P31/10
CPC分类号： A61K31/496
摘要： The present invention relates to a pharmaceutical composition comprising crystalline form Y of posaconazole. The pharmaceutical composition can be used to treat or prevent fungal infections.
摘要翻译： 本发明涉及包含泊沙康唑的晶形Y的药物组合物。 药物组合物可用于治疗或预防真菌感染。
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公开(公告)号：US20130012481A1
公开(公告)日：2013-01-10
申请号：US13550665
申请日：2012-07-17
申请人： Josef Wieser , Andreas Hotter , Arthur Pichler
发明人： Josef Wieser , Andreas Hotter , Arthur Pichler
CPC分类号： C07C237/26 , C07B2200/13 , C07C2603/46
摘要： The present invention relates to crystalline forms A and B of Tigecycline hydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline forms A and B of Tigecycline hydrochloride as intermediates for the formulation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form A of Tigecycline hydrochloride in an effective amount and to the use of crystalline form A of Tigecycline hydrochloride as anti-infective medicament.
摘要翻译： 本发明涉及盐酸替加环素的结晶形式A和B及其制备方法。 此外，本发明涉及盐酸替加环素的结晶形式A和B在制备抗感染药物中的用途。 此外，本发明涉及包含有效量的盐酸替加环素的结晶形式A和使用盐酸替加环素的结晶形式A作为抗感染药物的药物组合物。
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公开(公告)号：US20120101277A1
公开(公告)日：2012-04-26
申请号：US13379060
申请日：2010-07-09
IPC分类号： C07D405/14 , A61P31/10
CPC分类号： C07D405/14
摘要： The present invention relates to crystalline form II-S, its preparation and its use to prepare other crystalline forms of posaconazole, in particular crystalline form IV of posaconazole.
摘要翻译： 本发明涉及结晶形式II-S，其制备方法及其用于制备泊沙康唑的其它结晶形式，特别是泊沙康唑的IV型结晶形式。
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公开(公告)号：US20110065722A1
公开(公告)日：2011-03-17
申请号：US12993351
申请日：2009-06-25
IPC分类号： A61K31/496 , C07D403/14 , A61P31/10
CPC分类号： C07D405/06 , C07D405/14
摘要： The present invention relates to crystalline form IV of posaconazole and pharmaceutical compositions comprising the same. The pharmaceutical composition can be used to treat or prevent fungal infections.
摘要翻译： 本发明涉及泊沙康唑的结晶形式IV及包含其的药物组合物。 药物组合物可用于治疗或预防真菌感染。
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公开(公告)号：US20100160264A1
公开(公告)日：2010-06-24
申请号：US12665330
申请日：2008-06-20
申请人： Josef Wieser , Arthur Pichler , Andreas Hotter
发明人： Josef Wieser , Arthur Pichler , Andreas Hotter
IPC分类号： A61K31/65 , C07C237/26 , A61P31/00
CPC分类号： C07C237/26 , C07C2603/46
摘要： The present invention relates to the new crystalline solid form VI and VIII of tigecycline and processes for the production of form VI and VIII. It further relates to a new method for preparing Form I and Form III in high polymorphic purity.
摘要翻译： 本发明涉及替加环素的新结晶固体形式VI和VIII以及生产VI和VIII型的方法。 它还涉及一种制备高多晶型纯度的I型和III型的新方法。
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