公开(公告)号：US20060241019A1

公开(公告)日：2006-10-26

申请号：US10565900

申请日：2004-07-26

申请人： Dominique Bridon ,  Jean-Paul Castaigne ,  Xicai Huang ,  Roger Leger ,  Martin Robitaille

发明人： Dominique Bridon ,  Jean-Paul Castaigne ,  Xicai Huang ,  Roger Leger ,  Martin Robitaille

IPC分类号： A61K38/28 ,  C07K14/62

CPC分类号： A61K38/28 ,  A61K47/643 ,  C07K14/62

摘要： The present invention relates to an insulin derivative comprising an insulin molecule and a reactive group for covalently bonding a blood component, wherein preferably the insulin molecule is human natural insulin molecule and the reactive group is coupled to an amino acid of the insulin molecule at a position selected from the positions Gly A1, Phe B1 and Lys B29.

摘要翻译： 本发明涉及包含胰岛素分子和用于共价键合血液成分的反应性基团的胰岛素衍生物，其中优选地，胰岛素分子是人天然胰岛素分子，并且反应性基团与胰岛素分子的氨基酸在位置 选自Gly A1，Phe B1和Lys B29。

公开(公告)号：US07121497B2

公开(公告)日：2006-10-17

申请号：US11286339

申请日：2005-11-25

申请人： Martin Robitaille ,  Steve Gagnon ,  Alain Carbonneau

发明人： Martin Robitaille ,  Steve Gagnon ,  Alain Carbonneau

IPC分类号： B65H23/00 ,  B65H57/18

CPC分类号： B65H16/06 ,  B65H16/005 ,  B65H35/0006

摘要： An apparatus to prevent strip material from falling off the edges of a strip material package when unwinding. The package comprises a generally cylindrical and flangeless core around which the strip material is wound transversely in a plurality of overlapping layers. The apparatus also includes an idler roller. When unwinding, the strip material goes around the idler roller, then around the package, generally in its central portion and then again around the idler roller before being fed to a laminating machine. A method to use the apparatus is also provided.

公开(公告)号：US20050176643A1

公开(公告)日：2005-08-11

申请号：US11067556

申请日：2005-02-25

申请人： Dominique Bridon ,  Roger Leger ,  Xicai Huang ,  Karen Thibaudeau ,  Martin Robitaille ,  Peter Milner

发明人： Dominique Bridon ,  Roger Leger ,  Xicai Huang ,  Karen Thibaudeau ,  Martin Robitaille ,  Peter Milner

IPC分类号： A61K38/17 ,  C07K7/08

CPC分类号： C07K14/57545 ,  A61K38/00 ,  C07K19/00 ,  C07K2319/01

摘要： The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.

摘要翻译： 本发明涉及包含与反应性基团偶联的PYY肽或其功能性衍生物的化合物。 这样的反应性基团能够对血液成分进行反应，与其形成稳定的共价键。 本发明还涉及包含共价键合到血液成分上的化合物的缀合物。 此外，本发明还涉及在患者中增强PYY肽或其功能性衍生物的抗肥胖活性的方法。

公开(公告)号：US20050070475A1

公开(公告)日：2005-03-31

申请号：US10950010

申请日：2004-09-24

申请人： Dominique Bridon ,  Robert Dufresne ,  Nissab Boudjellab ,  Martin Robitaille ,  Peter Milner

发明人： Dominique Bridon ,  Robert Dufresne ,  Nissab Boudjellab ,  Martin Robitaille ,  Peter Milner

IPC分类号： A61K38/00 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  A61K38/17 ,  C07K14/47

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/16122

摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.

摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。

公开(公告)号：US20060071117A1

公开(公告)日：2006-04-06

申请号：US11286339

申请日：2005-11-25

申请人： Martin Robitaille ,  Steve Gagnon ,  Alain Carbonneau

发明人： Martin Robitaille ,  Steve Gagnon ,  Alain Carbonneau

IPC分类号： B65H16/00

CPC分类号： B65H16/06 ,  B65H16/005 ,  B65H35/0006

摘要： An apparatus to prevent strip material from falling off the edges of a strip material package when unwinding. The package comprises a generally cylindrical and flangeless core around which the strip material is wound transversely in a plurality of overlapping layers. The apparatus also includes an idler roller. When unwinding, the strip material goes around the idler roller, then around the package, generally in its central portion and then again around the idler roller before being fed to a laminating machine. A method to use the apparatus is also provided.

摘要翻译： 一种防止条带材料在展开时从条带材料包装边缘脱落的装置。 该包装件包括大致圆柱形和无凸缘的芯，围绕该芯材横向地缠绕条带材料在多个重叠层中。 该设备还包括惰轮。 当松开时，条带材料在被送入层压机之前绕过惰轮，然后围绕包装，通常在其中心部分中，然后再绕着惰辊卷绕。 还提供了使用该装置的方法。

公开(公告)号：US20050279462A1

公开(公告)日：2005-12-22

申请号：US11209818

申请日：2005-08-24

申请人： Martin Robitaille ,  Steve Cagnon

发明人： Martin Robitaille ,  Steve Cagnon

IPC分类号： B31F1/28 ,  B32B37/00 ,  B31F5/00 ,  B65H29/00

CPC分类号： B65H39/16 ,  B31F1/2886 ,  B65H2301/43151 ,  B65H2403/52 ,  B65H2511/20 ,  B65H2701/1762 ,  Y10T156/1016 ,  Y10T156/1025 ,  Y10T156/1702 ,  Y10T156/1712 ,  Y10T156/1744 ,  Y10T156/1788 ,  B65H2220/02 ,  B65H2220/04 ,  B65H2220/11 ,  B65H2220/09

摘要： This invention relates to an improvement in an apparatus for dispensing a ribbon between layers of web material and more particularly, to an automated and remote positioning system of ribbon dispensers which are precisely positioned with respect to the web material by a controlling and monitoring system and are physically easily accessible for maintenance by an operator. The automated and remote positioning system of ribbon dispensers includes locking means interacting with either the apparatus or with a traversing mechanism such as a lead screw to move the ribbon dispensers.

摘要翻译： 本发明涉及一种用于在卷筒纸材料层之间分配带状物的装置的改进，更具体地说，涉及一种色带分配器的自动和远程定位系统，其通过控制和监测系统相对于幅材材料精确定位，并且 物理上方便操作者进行维护。 色带分配器的自动和远程定位系统包括与装置或与诸如导螺杆的横动机构相互作用的锁定装置，以移动色带分配器。