公开(公告)号：US20090062529A1

公开(公告)日：2009-03-05

申请号：US12200731

申请日：2008-08-28

申请人： Teiji KIMURA ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Yu Yoshida ,  Toshiyuki Uemura ,  Takashi Doko ,  Daisuke Shinmyo ,  Daiju Hasegawa ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

发明人： Teiji KIMURA ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Yu Yoshida ,  Toshiyuki Uemura ,  Takashi Doko ,  Daisuke Shinmyo ,  Daiju Hasegawa ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

IPC分类号： C07D487/04 ,  C07D498/04

CPC分类号： C07D403/10 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14

摘要： A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

摘要翻译： 由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可被取代的苯基等 具有C 1-6烷氧基，X 1表示双键等，Het表示可以被C 1-6烷基等取代的三唑基等，作为治疗或预防药物是有效的 由Abeta引起的疾病

公开(公告)号：US20070219181A1

公开(公告)日：2007-09-20

申请号：US11715440

申请日：2007-03-08

申请人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Eriko Doi ,  Mamoru Takaishi ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Takashi Doko

发明人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Eriko Doi ,  Mamoru Takaishi ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Takashi Doko

IPC分类号： A61K31/553 ,  A61K31/55 ,  A61K31/5383 ,  A61K31/498 ,  A61K31/506

CPC分类号： C07D403/10 ,  C07D471/04 ,  C07D498/04

摘要： The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, Ar2 represents a phenyl group that may be substituted with a C1-6 alkoxy group, or the like, X1 represents a double bond or the like, and Het represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the like, which is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

摘要翻译： 本发明提供由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等 Ar 2表示可以被C 1-6烷氧基等取代的苯基，X 1表示双键等，Het表示 可被C 1-6烷基取代的咪唑基等作为由Aβ引起的疾病的治疗或预防剂有效。

公开(公告)号：US20060004013A1

公开(公告)日：2006-01-05

申请号：US11136355

申请日：2005-05-25

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Kogyoku Shin ,  Takehiko Miyagawa ,  Toshihiko Kaneko ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Kogyoku Shin ,  Takehiko Miyagawa ,  Toshihiko Kaneko ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

IPC分类号： A61K31/498 ,  A61K31/4745 ,  A61K31/46

CPC分类号： C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04

摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.

摘要翻译： 本发明涉及由式（I）表示的化合物：（其中Ar 1代表可被1至3个取代基取代的咪唑基; Ar 2表示 吡啶基，嘧啶基或可被1至3个取代基取代的苯基; X 1表示（1）-C≡C-或（2）双键等，其可以 被取代; R 1和R 2表示例如可以被取代的C 1-6烷基或C 3-8环烷基）或其药理学上可接受的盐 以及作为药剂的用途。 本发明的目的是找到由Abeta引起的疾病的治疗或预防剂。 根据本发明，可以提供由Abeta引起的疾病的治疗或预防剂。