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    Process for the preparation of Retapamulin and its intermediates
    33.
    发明申请
    Process for the preparation of Retapamulin and its intermediates 审中-公开
    雷帕帕林及其中间体的制备方法

    公开(公告)号：US20090149655A1

    公开(公告)日：2009-06-11

    申请号：US12315782

    申请日：2008-12-05

    申请人： Lilach Hedvati ,  Eyal Gilboa ,  Sharon Avhar-Maydan ,  Sharona Shachan-Tov

    发明人： Lilach Hedvati ,  Eyal Gilboa ,  Sharon Avhar-Maydan ,  Sharona Shachan-Tov

    IPC分类号： C07D451/06

    CPC分类号： C07D451/04

    摘要： Processes for preparing tropine derivatives of the following Formula B are provided where LG represents a leaving group. The tropine derivatives may be used to prepare Retapamulin, preferably in substantially pure form. Also provided are processes for preparing Retapamulin comprising combining a base, tropine thiol in a free base or salt form, an organic solvent, and a pleuromutilin derivative of Formula A:

    摘要翻译： 提供制备下式B的托品衍生物的方法，其中LG代表离去基团。 托品衍生物可用于制备雷帕那普宁，优选以基本上纯的形式。 还提供了制备雷帕帕林的方法，其包括将游离碱或盐形式的碱，托品硫代硫醇，有机溶剂和式A的去甲孕素衍生物：

    Crystalline forms of pregabalin
    34.
    发明授权
    Crystalline forms of pregabalin 失效
    普瑞巴林的结晶形式

    公开(公告)号：US07417165B2

    公开(公告)日：2008-08-26

    申请号：US11400484

    申请日：2006-04-06

    申请人： Judith Aronhime ,  Sigalit Levi ,  Lilach Hedvati

    发明人： Judith Aronhime ,  Sigalit Levi ,  Lilach Hedvati

    IPC分类号： C07C205/00 ,  C07C227/00 ,  C07B55/00

    CPC分类号： C07C227/42 ,  C07C229/08

    摘要： Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7° 2θ±0.2° 2θ, methods for its preparation, its pharmaceutical compositions thereof, and methods for the preparation of crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.7, 15.4, 17.2, 18.2, and 23.0° 2θ±0.2° 2θ, are provided.

    摘要翻译： 在约5.8,18.4,19.2,20.7和23.7±2θ±0.2°2θ处的X射线粉末衍射峰的特征的普瑞巴林的结晶形式，其制备方法，其药物组合物和制备结晶形式的 提供了以约5.7,5.4,47.2,18.2和23.0°±0.2°±2θ的X射线粉末衍射峰为特征的普瑞巴林。