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31.发明授权Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response 有权治疗或抑制与炎症反应相关的病理状况的协同组合物公开(公告)号：US08142819B2
公开(公告)日：2012-03-27
申请号：US10464410
申请日：2003-06-18
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K31/122 , A61K31/12 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。
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32.发明授权Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response 有权治疗或抑制与炎症反应相关的病理状况的协同组合物公开(公告)号：US07790205B2
公开(公告)日：2010-09-07
申请号：US11344561
申请日：2006-01-30
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K31/122 , A61K31/12 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。
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公开(公告)号：USD537381S1
公开(公告)日：2007-02-27
申请号：US29252495
申请日：2006-01-24
申请人： Terrence Howell
设计人： Terrence Howell
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34.发明授权Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 有权显示出对环氧合酶-2的表达和/或活性具有协同抑制作用的曲霉类组合物公开(公告)号：US06979470B2
公开(公告)日：2005-12-27
申请号：US10198277
申请日：2002-07-16
IPC分类号： A61K31/366 , A61K31/704 , A61K36/00 , A61K36/9066 , A61K35/78
CPC分类号： A61K31/365 , A61K31/047 , A61K31/075 , A61K31/12 , A61K31/19 , A61K31/366 , A61K31/56 , A61K31/704 , A61K36/00 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.
摘要翻译： 公开了包含对诱导型COX-2活性的特异性抑制具有协同作用并且对COX-1活性影响最小的有效量的姜黄素类物质和有效量的二萜内酯物质，三萜类或其衍生物的组合物 。 还公开了使用该组合物提供协同抗炎作用的方法。
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35.发明申请公开(公告)号：US20100184857A1
公开(公告)日：2010-07-22
申请号：US12564174
申请日：2009-09-22
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A61K31/122 , A61K31/215
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译： 本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。
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36.发明授权公开(公告)号：US07666449B2
公开(公告)日：2010-02-23
申请号：US11355145
申请日：2006-02-15
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译： 本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。
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公开(公告)号：US06629835B2
公开(公告)日：2003-10-07
申请号：US09920339
申请日：2001-08-01
IPC分类号： A61K3578
CPC分类号： A61K31/365 , A61K47/54 , Y10S514/825 , Y10S514/885 , Y10S514/886 , A61K31/34 , A61K2300/00
摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
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38.发明授权公开(公告)号：US07815944B2
公开(公告)日：2010-10-19
申请号：US11355306
申请日：2006-02-15
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulis lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译： 本发明提供啤酒花（Humulis lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。
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公开(公告)号：US07807203B2
公开(公告)日：2010-10-05
申请号：US12564174
申请日：2009-09-22
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
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40.发明授权Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2 失效倍半萜内酯和二环三烯内酯的组合用于环加氧酶-2的协同抑制公开(公告)号：US06908630B2
公开(公告)日：2005-06-21
申请号：US09919349
申请日：2001-07-31
IPC分类号： A61K31/365 , A61K31/7008 , A61K31/7016 , A61K31/7048 , A61K31/737 , A61K36/28 , A61K36/37 , A61K45/06 , A61K35/78 , A01N43/08 , A01N43/16
CPC分类号： A61K45/06 , A61K31/365 , A61K31/7008 , A61K31/7016 , A61K31/7048 , A61K31/737 , A61K36/28 , A61K36/37 , A61K2300/00
摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component of a sesquiterpene lactone species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
摘要翻译： 提供了一种用于抑制动物炎症反应的新型制剂。 该制剂作为第一组分包含有效量的二萜三环内酯物质和有效量的第二组分的倍半萜内酯物质或其衍生物，并且响应于物理或化学损伤或异常而提供协同抗炎作用 由于生物制剂或未知病因引起的免疫刺激。
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