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公开(公告)号：US07437189B2
公开(公告)日：2008-10-14
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译： 离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透 第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。
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公开(公告)号：US20070197955A1
公开(公告)日：2007-08-23
申请号：US11549031
申请日：2006-10-12
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device may include: an electric power source; a first electrode assembly coupled to the electric power source; and a second electrode assembly as a counter electrode of the first electrode assembly. The first electrode assembly may include an adhesive portion that facilitates contact between a mucous membrane and the first electrode assembly. The adhesive portion may be placed on a portion of an end surface portion of an electrode assembly, and may be made from a material that exhibits adhesiveness after absorbing an aqueous medium.
摘要翻译： 离子渗透装置可以包括：电源; 耦合到所述电源的第一电极组件; 以及作为第一电极组件的对电极的第二电极组件。 第一电极组件可以包括便于粘膜和第一电极组件之间的接触的粘合剂部分。 粘合剂部分可以放置在电极组件的端面部分的一部分上，并且可以由在吸收水性介质之后表现出粘附性的材料制成。
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公开(公告)号：US20070112294A1
公开(公告)日：2007-05-17
申请号：US11522496
申请日：2006-09-14
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.
摘要翻译： 离子电渗装置可能能够防止在通电时产生气体或离子，和/或可以防止由于电极反应而引起的活性剂离子的改变。 从电极到活性剂储存器的通电可以通过离子液体进行。 离子液体可以包括阴离子如PF6-，BF4-，AlCl4-，ClO4-，硫酸氢根离子，双 - 三氟 - 烷基 - 磺酰基 - 酰亚胺或三氟 - 甲烷磺酸盐，和阳离子如咪唑鎓 衍生物，吡啶鎓衍生物，哌啶鎓衍生物，吡咯烷鎓衍生物和四烷基铵衍生物。
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公开(公告)号：US20070060860A1
公开(公告)日：2007-03-15
申请号：US11506598
申请日：2006-08-18
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448
摘要： One or more electrodes of an iontophoresis device may include a composite ion exchange membrane comprising a first ion exchange membrane of a first polarity and a second ion exchange membrane of a second polarity, or a first ion exchange membrane of the first polarity, a semi-permeable membrane, and a second ion exchange membrane of the second polarity. The respective membranes may be integrally coupled together. This may lead to simplified production processes, automated production, mass production, and reductions in production costs for the iontophoresis device.
摘要翻译： 离子电渗装置的一个或多个电极可以包括复合离子交换膜，其包括第一极性的第一离子交换膜和第二极性的第二离子交换膜，或第一极性的第一离子交换膜， 和第二极性的第二离子交换膜。 各个膜可以整体耦合在一起。 这可能导致简化的生产过程，自动化生产，批量生产以及降低离子电渗装置的生产成本。
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35.发明申请Iontophoresis device controlling administration amount and administration period of plurality of drugs 审中-公开离子渗透装置控制多种药物的给药量和给药期公开(公告)号：US20070021711A1
公开(公告)日：2007-01-25
申请号：US11473515
申请日：2006-06-22
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444 , A61N1/30
摘要： An iontophoresis device capable of administering a plurality of drugs to a living body while controlling the administration amounts and the administration periods thereof is described. The iontophoresis device may comprise: a power source device; a drug administration unit connected to the power source device and including at least two electrode structures that hold an ionic drug; and a current control unit that individually controls currents flowing to the electrode structures. A predetermined amount of the ionic drug may be released from each of the electrode structures to be administered transdermally to a living body in a predetermined period of time according to a current flowing from the current control unit.
摘要翻译： 描述能够在控制给药量和给药期的同时向活体施用多种药物的离子电渗疗法装置。 离子渗透装置可以包括：电源装置; 连接到电源装置并且包括至少两个保持离子药物的电极结构的药物管理单元; 以及电流控制单元，其分别控制流向电极结构的电流。 预定量的离子药物可以从每个电极结构释放，以根据从电流控制单元流出的电流在预定时间段内经皮给予生物体。
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公开(公告)号：US20060276742A1
公开(公告)日：2006-12-07
申请号：US11443564
申请日：2006-05-30
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device, and a control method thereof, may be capable of increasing movement speed of a drug into a living body and/or may be capable of administering a drug having a high molecular weight. The iontophoresis device may include an active electrode assembly comprising: a first electrode; a drug holding part that receives a current from the first electrode; and a first ion exchange membrane that selectively passes ions of a first polarity, the first ion exchange membrane being placed on a front side of the drug holding part. Drug ions of the first polarity generated by the dissociation of a drug held in the drug holding part may be administered to a living body through the first ion exchange membrane in contact with skin of the living body. The iontophoresis device may include heating means to heat the skin in contact with the first ion exchange membrane.
摘要翻译： 离子电渗装置及其控制方法可以使药物进入活体的移动速度和/或能够施用高分子量的药物。 离子电渗装置可以包括有源电极组件，其包括：第一电极; 药物保持部，其从所述第一电极接收电流; 以及第一离子交换膜，其选择性地通过第一极性的离子，所述第一离子交换膜被放置在所述药物保持部的前侧。 可以通过与生物体的皮肤接触的第一离子交换膜向生物体施用通过药物保持部的药物解离而产生的第一极性的药物离子。 离子电渗装置可以包括加热装置以加热与第一离子交换膜接触的皮肤。
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公开(公告)号：US20060217654A1
公开(公告)日：2006-09-28
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译： 离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透 第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。
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公开(公告)号：US20060129085A1
公开(公告)日：2006-06-15
申请号：US11172372
申请日：2005-06-30
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device for administering drug ions via the first ion-exchange membrane, comprising a first semi-permeable film having a number of pores passing through the film from a front surface to a back surface, a first ion-exchange membrane formed of ion-exchange resin filling the pores of the first semi-permeable film and selective ions of a first polarity, and a working electrode structure having a drug holding part placed on a back surface of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity, wherein a layer of a water-soluble polymer compound chemically bonded on the surface of the first semi-permeable film.
摘要翻译： 1.一种用于经由第一离子交换膜施用药物离子的离子电渗疗法装置，其特征在于，具有从前表面到背面通过所述膜的多孔的第一半透膜，由离子交换膜形成的第一离子交换膜， 填充第一半透膜的孔和第一极性的选择性离子的交换树脂，以及具有放置在第一离子交换膜的背面上的药物保持部并保持含有药物离子的药液的工作电极结构 以第一极性充电，其中化学键合在第一半透膜上的水溶性高分子化合物层。
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39.发明申请公开(公告)号：US20070027426A1
公开(公告)日：2007-02-01
申请号：US11475838
申请日：2006-06-26
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： An iontophoresis device includes an active electrode assembly which comprises an active electrode element and an outermost active electrode ion selective membrane that caches an active agent. The outermost active electrode ion selective membrane may be formed by one or more ion exchange membranes. The active electrode assembly may also comprise an electrolyte and/or one or more inner active electrode ion selective membranes. The inner active electrode ion selective membrane may be a “leaky” ion selective membrane. The inner active electrode ion exchange membrane may be spaced from the outermost active electrode ion selective membrane, for example, by one or more non-ion selective porous membranes or by a buffer material and/or buffer reservoir. An iontophoresis device may also include a counter electrode assembly and/or voltage source.
摘要翻译： 离子电渗装置包括活性电极组件，其包括活性电极元件和缓冲活性剂的最外面的活性电极离子选择性膜。 最外面的活性电极离子选择膜可以由一个或多个离子交换膜形成。 有源电极组件还可以包括电解质和/或一个或多个内部有源电极离子选择膜。 内部活性电极离子选择性膜可以是“泄漏”离子选择性膜。 内部有源电极离子交换膜可以与最外面的有源电极离子选择膜间隔开，例如通过一个或多个非离子选择性多孔膜或通过缓冲材料和/或缓冲储器隔开。 离子电渗装置还可以包括对电极组件和/或电压源。
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公开(公告)号：US20090171313A1
公开(公告)日：2009-07-02
申请号：US12336122
申请日：2008-12-16
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device transdermally administers an active agent, such as a drug ion, to a biological interface of an organism. The iontophoresis device includes a first electrode assembly having a first electrode member, which is electrically coupled to a terminal, of a main electric power source, having a first polarity that is the same polarity as that of a drug ion. The iontophoresis device includes a drug solution reservoir arranged in an electric field generated by the first electrode member and holding a drug, a counter electrode assembly electrically coupled to another terminal (of the main electric power source) having a second polarity that is opposite to the first polarity, and a vibrating portion having an ultrasonic oscillator for oscillating an ultrasonic wave and an ultrasonic vibrator vibrating due to the ultrasonic wave supplied from the ultrasonic oscillator. The ultrasonic vibrator is provided in the vicinity of the active electrode assembly.
摘要翻译： 离子电渗装置将活性剂（例如药物离子）经皮施用于生物体的生物界面。 离子电渗装置包括：第一电极组件，其具有与主电源电连接的端子的第一电极部件，第一电极部件具有与药物离子极性相同的第一极性。 离子电渗疗法装置包括：药物储存器，其设置在由第一电极部件产生的电场中并且保持药物;对电极组件，其电耦合到具有第二极性的第二极性，该第二极性与第二极性相反; 第一极性，以及振动部，其具有振动超声波的超声波振荡器和由超声波振荡器供给的超声波而振动的超声波振子。 超声波振动器设置在有源电极组件的附近。
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