公开(公告)号：US20230170045A1

公开(公告)日：2023-06-01

申请号：US17920012

申请日：2021-04-16

Applicant: Myriad Genetics, Inc.

Inventor： Shannon Gallagher ,  Elisha Hughes ,  Alexander Gutin ,  Jerry Lanchbury

IPC: G16B20/20 ,  C12Q1/6886 ,  G16H50/30

CPC classification number: G16B20/20 ,  C12Q1/6886 ,  G16H50/30 ,  C12Q2600/156

Abstract: Provided herein are methods for determining a polygenic risk score and breast cancer estimated risk for medical use, as well as for treating breast cancer. Methods of this invention can provide a polygenic risk score which takes into account a plurality of breast cancer associated SNP markers. Also provide is a comprehensive breast cancer risk estimation with increased accuracy.

公开(公告)号：US20230111438A1

公开(公告)日：2023-04-13

申请号：US18081586

申请日：2022-12-14

Applicant: Myriad Genetics, Inc.

Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/6886 ,  G16B20/20 ,  G16B20/10 ,  A61K33/243 ,  A61K31/282

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20220205046A1

公开(公告)日：2022-06-30

申请号：US17499284

申请日：2021-10-12

Applicant: Myriad Genetics, Inc.

Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/6886 ,  C12Q1/6827 ,  G16B20/00 ,  G16H20/00 ,  G16B20/20 ,  G16B20/10

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US11174519B2

公开(公告)日：2021-11-16

申请号：US16691480

申请日：2019-11-21

Applicant: MYRIAD GENETICS, INC.

Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/6886 ,  C12Q1/6827 ,  G16B20/00 ,  G16H20/00 ,  G16B20/20 ,  G16B20/10

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US10851425B2

公开(公告)日：2020-12-01

申请号：US16576643

申请日：2019-09-19

Applicant: MYRIAD GENETICS, INC.

Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/6886 ,  C12Q1/6827 ,  G16B20/00

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US10400287B2

公开(公告)日：2019-09-03

申请号：US15433249

申请日：2017-02-15

Applicant: Myriad Genetics, Inc.

Inventor： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin ,  Julia Reid

IPC: C12Q1/68 ,  C12Q1/6886

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20190153542A1

公开(公告)日：2019-05-23

申请号：US16256908

申请日：2019-01-24

Applicant: Myriad Genetics, Inc.

Inventor： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC: C12Q1/6886 ,  G16B20/00

Abstract: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20180334722A1

公开(公告)日：2018-11-22

申请号：US15921416

申请日：2018-03-14

Applicant: Myriad Genetics, Inc.

Inventor： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia E. Reid

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US09279156B2

公开(公告)日：2016-03-08

申请号：US14109163

申请日：2013-12-17

Applicant: Myriad Genetics, Inc.

Inventor： Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6874 ,  C12Q1/6883 ,  G06F19/22 ,  C12Q2535/122 ,  C12Q2537/143

Abstract: Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.

Abstract translation: 提供了使用核酸测序检测等位基因不平衡的方法和系统。

公开(公告)号：US20150232947A1

公开(公告)日：2015-08-20

申请号：US14632622

申请日：2015-02-26

Applicant: Myriad Genetics, Inc.

Inventor： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B20/00 ,  G16B40/00

Abstract: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

Abstract translation: 提供了使用生物标志物预测患者癌症复发风险的生物标志物和方法。