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    METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY
    1.
    发明申请
    METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY 审中-公开

    公开(公告)号：US20200087737A1

    公开(公告)日：2020-03-19

    申请号：US16691480

    申请日：2019-11-21

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

    IPC: C12Q1/6886 ,  C12Q1/6827 ,  G16B20/00

    Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

    METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY
    2.
    发明申请
    METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY 审中-公开

    公开(公告)号：US20200010913A1

    公开(公告)日：2020-01-09

    申请号：US16576643

    申请日：2019-09-19

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

    IPC: C12Q1/6886

    Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

    Methods and materials for assessing loss of heterozygosity
    9.
    发明授权
    Methods and materials for assessing loss of heterozygosity 有权
    评估杂合度丧失的方法和材料

    公开(公告)号：US09388472B2

    公开(公告)日：2016-07-12

    申请号：US14307708

    申请日：2014-06-18

    Applicant: Myriad Genetics, Inc.

    Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  A61K31/282 ,  A61K33/24 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

    Abstract translation: 本文件提供了评估样品（例如癌细胞）中存在杂合性（LOH）特征丧失的方法和材料。 例如，提供了用于确定细胞（例如，癌细胞）是否包含LOH标记的方法和材料。 还提供了用于鉴别具有同源性定向修复（HDR）缺陷的细胞（例如癌细胞）的材料和方法以及用于鉴定可能对特定癌症治疗方案作出反应的癌症患者的材料和方法。

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