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公开(公告)号：US20180170908A1
公开(公告)日：2018-06-21
申请号：US15839901
申请日：2017-12-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , C07D471/04 , C07D405/14 , C07D413/14 , A61P3/10 , A61P25/28 , A61P25/02 , A61P13/12 , A61P43/00 , A61P3/04 , A61P1/16 , A61P9/10 , A61P19/02 , A61P25/16 , A61P19/06 , A61P15/10 , A61P17/06 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/30
CPC classification number: C07D401/14 , A61K31/4545 , A61K31/496 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P43/00 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US11802121B2
公开(公告)日：2023-10-31
申请号：US18049052
申请日：2022-10-24
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: A61K31/496 , A61K31/4545 , C07D401/14 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
CPC classification number: C07D401/14 , A61K31/4545 , A61K31/496 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P43/00 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US11512070B2
公开(公告)日：2022-11-29
申请号：US17085534
申请日：2020-10-30
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US11471458B2
公开(公告)日：2022-10-18
申请号：US17062982
申请日：2020-10-05
Applicant: Pfizer Inc.
Inventor： David James Edmonds , Kevin James Filipski , Kentaro Futatsugi , Michelle Renee Garnsey , Jack Chang Hung Lee , Daniel Jonathan Smaltz
IPC: A61K31/506 , A61P3/06 , A61K31/155 , A61K31/4545 , C07D401/14 , A61K31/4985 , A61K31/7048 , A61K45/06
Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.
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公开(公告)号：US11034678B2
公开(公告)日：2021-06-15
申请号：US16793441
申请日：2020-02-18
Applicant: Pfizer Inc.
Inventor： Markus Boehm , Shawn Cabral , Matthew S. Dowling , Kentaro Futatsugi , Kim Huard , Esther Cheng Yin Lee , Allyn T. Londregan , Jana Polivkova , David A. Price , Qifang Li
IPC: C07D401/04 , C07D405/14 , C07D401/14 , A61K31/506 , A61K45/06 , C07D409/14
Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
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Patent Agency Ranking
公开(公告)号：US20210100798A1
公开(公告)日：2021-04-08
申请号：US17090619
申请日：2020-11-05
Applicant: Pfizer Inc.
Inventor： David James Edmonds , Kevin James Filipski , Kentaro Futatsugi , Michelle Renee Garnsey , Jack Chang Hung Lee , Daniel Jonathan Smaltz
IPC: A61K31/506 , A61K31/4545 , A61K31/155 , A61K31/7048 , A61K31/4985 , A61P3/06 , C07D401/14 , A61K45/06
Abstract: Described herein are compounds of Formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.
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公开(公告)号：US20210100796A1
公开(公告)日：2021-04-08
申请号：US17062982
申请日：2020-10-05
Applicant: Pfizer Inc.
Inventor： David James Edmonds , Kevin James Filipski , Kentaro Futatsugi , Michelle Renee Garnsey , Jack Chang Hung Lee , Daniel Jonathan Smaltz
IPC: A61K31/506 , C07D401/14 , A61K45/06 , A61P3/06 , A61K31/155 , A61K31/4985 , A61K31/7048 , A61K31/4545
Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.
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![Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors](/abs-image/US/2020/09/29/US10787438B2/abs.jpg.150x150.jpg)
公开(公告)号：US10787438B2
公开(公告)日：2020-09-29
申请号：US16744283
申请日：2020-01-16
Applicant: Pfizer Inc.
Inventor： Matthew Dowling , Dilinie Fernando , Kentaro Futatsugi , Kim Huard , Thomas Victor Magee , Brian Raymer , Andre Shavnya , Aaron Smith , Benjamin Thuma , Andy Tsai , Meihua Tu
IPC: C07D403/14 , A61K31/403 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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![SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS](/abs-image/US/2020/05/14/US20200148669A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200148669A1
公开(公告)日：2020-05-14
申请号：US16744283
申请日：2020-01-16
Applicant: Pfizer Inc.
Inventor： Matthew Dowling , Dilinie Fernando , Kentaro Futatsugi , Kim Huard , Thomas Victor Magee , Brian Raymer , Andre Shavnya , Aaron Smith , Benjamin Thuma , Andy Tsai , Meihua Tu
IPC: C07D403/14 , C07D403/04 , C07D401/14 , C07D401/04 , A61K31/403
Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US10208019B2
公开(公告)日：2019-02-19
申请号：US15839901
申请日：2017-12-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D401/14 , A61K31/496 , A61K31/4545 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , A61P3/00
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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