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公开(公告)号：US07671020B2
公开(公告)日：2010-03-02
申请号：US11614840
申请日：2006-12-21
CPC分类号： C07K14/50 , A61K38/1825 , C07K2319/00 , Y10S514/825
摘要： The present invention relates to methods of using zFGF5 compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for treating disorders associated with chondrocytes, such as cartilage injuries and defects. In addition, methods for treating neurological disorders, such as stroke, are disclosed, and methods for using zFGF5 compositions to stimulate growth of cells associated with neurological injury and disease are disclosed.
摘要翻译： 本发明涉及使用zFGF5组合物增殖软骨细胞及其祖细胞并诱导软骨沉积的方法。 公开了用于治疗与软骨细胞相关的疾病如软骨损伤和缺陷的zFGF5组合物。 此外，公开了治疗神经系统疾病如中风的方法，并且公开了使用zFGF5组合物刺激与神经损伤和疾病相关的细胞生长的方法。
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公开(公告)号：US20120263729A1
公开(公告)日：2012-10-18
申请号：US13533727
申请日：2012-06-26
IPC分类号： A61K39/395 , A61P9/00 , A61P29/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/2896 , C07K2317/34
摘要： The invention pertains to methods of treating cardiovascular disease by modulating inflammatory and immunoregulatory responses associated with such pathological conditions. Embodiments of the invention provide methods for the treatment of cardiovascular disease in a subject having cardiovascular disease comprising administering an effective amount of one or more IL-17 antagonists, IL-18 antagonists, 4-1BB antagonists, CD30 antagonists, OX40 antagonists and/or CD39 alone or in any combination. This abstract is provided for the sole purpose of enabling the reader to quickly ascertain the subject matter of the technical disclosure and is not intended to be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).
摘要翻译： 本发明涉及通过调节与这种病理状况相关的炎症和免疫调节反应来治疗心血管疾病的方法。 本发明的实施方案提供了在具有心血管疾病的受试者中治疗心血管疾病的方法，包括施用有效量的一种或多种IL-17拮抗剂，IL-18拮抗剂，4-1BB拮抗剂，CD30拮抗剂，OX40拮抗剂和/或 CD39单独或任何组合。 提供本摘要的唯一目的是使读者能够快速确定技术公开内容的主题，并不意图用于解释或限制权利要求书的范围或含义。 37 CFR 1.72（b）。
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公开(公告)号：US20120171723A1
公开(公告)日：2012-07-05
申请号：US13369837
申请日：2012-02-09
CPC分类号： A61K38/1825
摘要： The present invention relates to zFGF5 compositions and methods of using the compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for treating disorders associated with chondrocytes, such as cartilage injuries and defects. In addition, methods for treating neurological disorders, such as stroke, are disclosed, and methods for using zFGF5 compositions to stimulate growth of cells associated with neurological injury and disease are disclosed.
摘要翻译： 本发明涉及zFGF5组合物和使用该组合物增殖软骨细胞及其祖细胞并诱导软骨沉积的方法。 公开了用于治疗与软骨细胞相关的疾病如软骨损伤和缺陷的zFGF5组合物。 此外，公开了治疗神经系统疾病如中风的方法，并且公开了使用zFGF5组合物刺激与神经损伤和疾病相关的细胞生长的方法。
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公开(公告)号：US06902911B1
公开(公告)日：2005-06-07
申请号：US09186342
申请日：1998-11-04
CPC分类号： C07K14/47 , C07K2319/02
摘要： The present invention relates to polynucleotide and polypeptide molecules for z219c, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting various human disease states and chromosomal abnormalities. The present invention also includes antibodies to the z219c polypeptides.
摘要翻译： 本发明涉及z219c的多核苷酸和多肽分子，人类2-19蛋白家族的新成员。 多肽和编码它们的多核苷酸可用于检测各种人类疾病状态和染色体异常。 本发明还包括针对z219c多肽的抗体。
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