公开(公告)号：US20130121954A1

公开(公告)日：2013-05-16

申请号：US13592393

申请日：2012-08-23

申请人： Darren H. Wakefield ,  Nicholas A. Rossi ,  Dan Sheik

发明人： Darren H. Wakefield ,  Nicholas A. Rossi ,  Dan Sheik

IPC分类号： A61K47/48

CPC分类号： A61K47/48176 ,  A61K31/7105 ,  A61K47/58 ,  C08F218/04 ,  C08F218/10 ,  C08F2218/22 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

摘要： The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

公开(公告)号：US07501394B2

公开(公告)日：2009-03-10

申请号：US11337121

申请日：2006-01-20

申请人： Alexander V. Sokoloff ,  So Wong ,  Jon A. Wolff ,  Sean D. Monahan ,  James Ludtke ,  Lori Higgs ,  Darren H. Wakefield ,  Magdolna G. Sebestyén

发明人： Alexander V. Sokoloff ,  So Wong ,  Jon A. Wolff ,  Sean D. Monahan ,  James Ludtke ,  Lori Higgs ,  Darren H. Wakefield ,  Magdolna G. Sebestyén

IPC分类号： A61K38/00

CPC分类号： C07K14/005 ,  A61K41/00 ,  C12N2795/10222

摘要： We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.

摘要翻译： 我们描述与肝细胞结合并被内化的化合物。 这些化合物与其他分子或复合物的结合可用于在体内或体外靶向肝细胞的分子或复合物。