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公开(公告)号：US20080221148A1
公开(公告)日：2008-09-11
申请号：US11962044
申请日：2007-12-20
申请人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
发明人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/454 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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32.发明授权公开(公告)号：US07872018B2
公开(公告)日：2011-01-18
申请号：US11962044
申请日：2007-12-20
申请人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
发明人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/454 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译： 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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公开(公告)号：US08143271B2
公开(公告)日：2012-03-27
申请号：US13216200
申请日：2011-08-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US20120022098A1
公开(公告)日：2012-01-26
申请号：US13216200
申请日：2011-08-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US20070032519A1
公开(公告)日：2007-02-08
申请号：US11435381
申请日：2006-05-16
申请人： Chao Zhang , Jiazhong Zhang , Prabha Ibrahim , Clarence Hurt , Rebecca Zuckerman , Dean Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
发明人： Chao Zhang , Jiazhong Zhang , Prabha Ibrahim , Clarence Hurt , Rebecca Zuckerman , Dean Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。
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公开(公告)号：US07504509B2
公开(公告)日：2009-03-17
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US08067434B2
公开(公告)日：2011-11-29
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US07947708B2
公开(公告)日：2011-05-24
申请号：US12244730
申请日：2008-10-02
CPC分类号： A61K31/4745
摘要： Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand identification and design.
摘要翻译： 提供了具有对受体蛋白酪氨酸激酶c-kit活性的7-氮杂吲哚核心结构的化合物，可用于治疗c-kit介导疾病或病症的组合物及其使用方法。 还提供了c-kit配体鉴定和设计的方法。
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公开(公告)号：US07498342B2
公开(公告)日：2009-03-03
申请号：US11154988
申请日：2005-06-16
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： A61K31/4745
摘要： Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand identification and design.
摘要翻译： 提供了具有对受体蛋白酪氨酸激酶c-kit活性的7-氮杂吲哚核心结构的化合物，可用于治疗c-kit介导疾病或病症的组合物及其使用方法。 还提供了c-kit配体鉴定和设计的方法。
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公开(公告)号：US20090105297A1
公开(公告)日：2009-04-23
申请号：US12244730
申请日：2008-10-02
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745
摘要： Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand identification and design.
摘要翻译： 提供了具有对受体蛋白酪氨酸激酶c-kit活性的7-氮杂吲哚核心结构的化合物，可用于治疗c-kit介导疾病或病症的组合物及其使用方法。 还提供了c-kit配体鉴定和设计的方法。
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